Method for in vitro monitoring of postoperative changes following liver transplantation

ABSTRACT

The present invention relates to the use of gene expression profiles, obtained in vitro from a patient sample, for detecting any postoperative tissue incompatibility reactions following a liver transplantation, wherein in patients the gene activity of a plurality of specific genes relevant to a liver transplantation is determined in a patient sample, and the specific genes and/or gene fragments for monitoring of postoperative states are selected from the group consisting of: SEQ-ID No. 1 to SEQ-ID No. 532, these preferably being subdivided into several clusters.

The present invention concerns the use of gene expression profiles of samples obtained in vitro from patients for the detection of possible postoperative tissue rejection reactions following a successful liver transplantation according to claim 1, a process for in vitro measurement of a gene expression profile of this type according to claim 13. The invention further concerns a use of the gene expression profile and/or of the therefore employed probe for switching off and/or for changing the activation of target genes and/or for determination of the gene activity for the determination of the risk of rejection in a patient who has received a transplant, according to claim 27, a kit according to claim 30 as well as clusters of polynucleotides according to claims 31 through 34.

The present invention further concerns a new possibility for monitoring postoperative developments following liver transplantations, for the early recognition of a possible risk of rejection.

The liver is one of the most important and largest internal organs in the human body, it is vitally important to almost all metabolic processes (Jecklin, 2004). The liver is not only the most essential organ for metabolism, but rather is also the detoxification central in the human body (Jecklin, 2004; Trebsdorf et al., 1998). However, the liver is liable to a number of diseases. The main causes, besides excessive alcohol consumption, involve bacterial or as the case may be viral infections (e.g. hepatitis) or hereditary factors. Frequently symptoms of a liver illness are diagnosed as everyday aches and pains and are treated too late (www.leber-info.de). Certain liver diseases (Table 1) lead to irreversible damage of the liver. Almost all forms of irreversible liver insufficiency with threat of organ failure will present potential indicators for liver transplantation (Penko and Tirbaso., 1999).

TABLE 1 Typical diseases which determine the necessity of the liver transplantation. Chronic hepatocellular diseases Hepatitis B Hepatitis C Hepatitis D Alcoholic cirrhosis of the liver Autoimmune hepatitis Chronic cholestatic diseases Primary biliary cirrhosis Primary sklerotic cholangitis Biliary Atresia Disfunction of liver metabolism Haemochromatosis Wilson Sydrome Alpha-1-antitrypsin deficiency Congenital metabolic dysfunction Oxalose Syndrome Urea cycle defect The bolded terms represent the most frequent indicators for liver transplantation (Penko and Tirbaso., 1999).

Damage due to liver disease as well as a late diagnosis could lead to liver failure. Liver failures have a high mortality and influence a variety of other organs (Bauer et al., 2005). Despite a high mortality due to liver failure, liver transplantation remains the preferred method of treatment, in the case that specific indications, such as, for example, King's College or Clichy criteria, prognosticate an unfavorable course of the disease or condition (Bauer et al., 2005). In the year 2003 in Germany alone there were 11,797 patients who were waiting for a donor organ, among these were 1266 persons with an urgent need for liver transplantation (www.dso.de). The problem of the long waiting lists due to the lack of sufficiently large pool of suitable donor organs has in no way been solved despite the efforts from many sides and the development of a European-wide donor organ notification center. The allogenic transplantation must be accompanied by a lifelong immunosuppression therapy, which suppresses the hyperacute, acute or chronic rejection reactions. Besides this, the relevant patients are often burdened with a reinfection, in particular with a viral infection such as Epstein-Barr or cytomegalovirus (CVM) infection (Gao and Zheng, 2004). Added to this are severe complications primarily in the early postoperative course, in particular failure of the transplanted liver and acute rejection crises. The postoperative rejection rate in liver transplantations is approximately 36% (Shimizu et al., 2003). Initial intensive medical monitoring and closely meshed postoperative care are thus of particular importance for the concerned patients (Müller and Neuhaus, 2004).

It is thus the task of the present invention to provide possibilities for in vitro diagnoses, which allow postoperative assessment as to whether a patient's transplanted donor liver is accepted or not and, in particular, in certain cases, prognosis for the occurrence of rejection reactions and for the early implementation of therapeutic measures.

The above task is solved by the uses according to claim 1 and claim 27.

Procedurally the task is solved by claim 13.

A kit according to claim 30 as well as clusters of polynucleotides according to claims 31 through 34 likewise solve the task.

The task is in particular solved by a use of gene expression profiles obtained in vitro from a patient sample for the determination of possible postoperative occurring tissue compatibility reactions following a successful liver transplantation.

The invention further concerns the evaluation of the accompanying therapeutic treatment of patients who have had a liver transplantation. Further the invention makes possible the use of gene expression profiles for the determination of the risk of rejection in a patient who has had a liver transplant.

The present invention can also be used for production of “in silico” expert systems and/or for “in silico”—modeling of cellular signal transmission pathways.

For producing the gene expression profile according to the present invention a plurality of specific genes and/or gene fragments are employed, which are selected from the group in Tables 6-9 comprised of SEQ-ID No. 1 through SEQ-ID No. 532 as well as gene fragments thereof with at least 5-2000, preferably 20-200, more preferably 20-80 nucleotides.

These sequences with the Sequence ID: 1 through Sequence ID: 532 are included within the scope of the present invention and are individually disclosed in the attached sequence protocol comprising 532 sequences, which is thus a component of the description of the present invention, and which is therewith likewise a component of the disclosure of the invention.

Beyond this, the present invention concerns the use of gene expression profiles obtained in vitro from patient samples and/or the therefore employed probes, which are selected from the group comprised of SEQ-ID No. 1 through SEQ-ID No. 532 as well as gene fragments thereof with at least 5-2000, preferably 20-200, more preferably 20-80 nucleotides, for switching off and/or for changing the activation of target genes and/or for determining the gene activity for monitoring postoperative changes following liver transplantation and/or for determining the gene activity for determining the rejection risk of a liver transplant patient.

A further embodiment of the invention is comprised in the generation of gene activity clusters, wherein, in the respective clusters, at least two genes and/or gene fragments from SEQ-ID No. 1 through SEQ-ID No. 532 are grouped, of which the expression profile remain similar over the most diverse patient samples or probes. In a further embodiment these gene activity clusters are compared with each other and make possible therewith a prediction regarding the postoperative changes of patients with liver transplants.

A further embodiment of the invention is characterized thereby, that a specific gene and/or gene fragment is selected from the group comprised of SEQ-ID No. 1 through SEQ-ID No. 532 as well as gene fragments thereof with at least 5-2000, preferably 20-200, more preferably 20-80 nucleotides.

A further embodiment of the invention is thereby characterized, that at least 2 to 100 different cDNAs are employed.

A further embodiment of the invention is thereby characterized, that at least 200 different sequences are employed.

A further embodiment of the invention is thereby characterized, that least 200 to 500 different sequences are employed.

A further embodiment of the invention is thereby characterized, that at least 500 different sequences are employed.

A further embodiment of the invention is thereby characterized, that the genes or gene fragments listed in claim 3 and/or of their RNA derived sequences are replaced by synthetic analogs, aptamers, as well as peptidonucleic acids.

A further embodiment of the invention is thereby characterized, that the synthetic analogs of the genes comprise 5-100, in particular approximately 70 base pairs.

A further embodiment of the invention is thereby characterized, that the gene activities are determined by a hybridization process.

A further embodiment of the invention is thereby characterized, that the gene activity is determined using microarrays.

A further embodiment of the invention is thereby characterized, that the gene activity is determined by hybridization dependent processes, in particular enzymatic and/or chemical hydrolysis and/or amplification processes, preferably PCR, subsequent quantification of the nucleic acids and/or of derivatives and/or fragments thereof.

A further embodiment of the invention is thereby characterized, that the sample is selected from: body fluids, in particular blood, serum, urine, ascites fluid, seminal fluid, saliva, aspirate; cellular contents or a mixture thereof.

A further embodiment of the invention is thereby characterized, that cell samples are in certain cases subjected to a lytic treatment, in order to release their cellular contents.

It is apparent to the person of ordinary skill in the art that the individual characteristics of the invention set forth in the claims can be combined freely with each other without reducing the scope of the invention.

As marker gene in the sense of the invention, all derived DNA-sequences, partial sequences and synthetic analogs (for example peptid nucleic acids, PNA) are understood. The description of the invention with reference to the determination of the gene expression on the RNA-level is not to be construed as a limitation but rather only one exemplary embodiment.

The description of the invention using blood provides only one example for the application of the invention. As biologic fluids in the sense of the invention, all body fluids of the human are to be understood.

For the purposes of a complete disclosure of the present teaching it has been determined that the originally filed claims individually and/or in combination are part of the disclosure for the person of ordinary skill. In particular the use according to one of claims 1 through 12 and a process according to one of claims 13 through 26 and/or for carrying out a process according to one of claims 13 through 26 are disclosed.

Further advantages and characteristics of the present invention can be seen on the basis of the description of an illustrated embodiment as well as on the basis of the figure.

There is shown:

FIG. 1: a color representation of similarities of expression behavior of certain gene associated gene clusters; and

FIG. 2: typical representations of 4 gene activity clusters with specific expression profiles.

ILLUSTRATIVE EMBODIMENT

For measuring the differential gene expression for monitoring postoperative changes following liver transplantation tests were carried out using full blood samples from a total of 22 patients, who were being treated on operative intensive care stations.

The illustrative embodiment is explained on the basis of the following illustration:

-   FIG. 1 shows the associated gene cluster for similarities of the     expression behavior of certain genes between individual samples.     -   Each point of the color matrix represents a relative expression         of a gene in a blood sample in relationship to a control, in the         case of the example Sig-M5, (vertical: patient sample with         increasing identification number; horizontal: 532 examined         genes). The respective colors represent the expression of the         individual genes, wherein red indicates relative expression         greater than the average and green relative expression indicates         smaller than the average values; gray fields indicate missing         values. -   FIG. 2 is concerned with typical representations of the 4 gene     activity clusters with specific expression profiles.     -   The first gene activity cluster is represented by the gene PPBP         (Sequence No. 112) (A); the second gene activity cluster by gene         MKNK1 (Sequence No. 220) (B), the third gene activity cluster by         the gene IL22RA2 (Sequence No. 3791 (C) and the fourth gene         activity duster by the gene IL2RB (Sequence No. 477) (D). The         points connected by the dashed line represent the group average         value. The gray perpendicular lines mark the average scatter         region within the patient group.

The first blood sample was taken immediately prior to the surgical intervention (t0). Directly following the interoperative phase (t0 post) or as the case may be following three (t3 post), seven (t7 post) and fourteen days (t14 post) further postoperative blood samples were obtained from all patients. Following collection of whole blood the total RNA of the sample was isolated using the PAXGene Blood RNA Kit according to the instructions of the manufacturer (Qiagen).

As reference sample there was employed the total RNA from the commercial obtainable monoblast leukamine cell line Sig-M5.

Depending upon the employed method for determination of the gene expression profile other control/reference sample/calibration controls, for example housekeeping or spike sequences, could be used.

Cell Cultivation

For cell cultivation (control samples) 19 cryocell cultures (SIG-M5) (frozen in liquid nitrogen) were used. The cells were respectively inoculated with 2 ml Isocove's Medium (Biochrom AG) and supplemented with 20% fetal caliber serum (FCS). The cell cultures were subsequently incubated for 24 hours at 37° C. under 5% CO₂ in 12-well plates. Thereafter the content of 18 wells were separated into 2 parts with respectively the same volume, so that in the end 3 plates of the same format (total 36 wells) were available. The cultivation was subsequently carried out for 24 hours using the same conditions. Subsequent thereto the resulting cultures of 11 wells of each plate were combined and centrifuged (1000×g, 5 min, room temperature). The supernatant was discarded and the cell pellet dissolved in 40 ml of the abovementioned medium. These cells dissolved in 40 ml were divided into two 250 ml flasks of equal parts and after 48 hours incubation and addition of 5 ml of above medium again incubated. From the remaining 2 ml of the two remaining plates 80 μl were introduced into empty wells of the same plates, which were already prepared with 1 ml of the above medium. After 48 hours incubation only one of the 12 well-plates was processed as follows: 500 μl were extracted from each well and combined. The therefrom resulting 6 ml were introduced into a 250 ml flask, which contained approximately 10 ml fresh medium. This mixture was centrifuged at 1000×g for 5 minutes at room temperature and dissolved in 10 ml of the abovementioned medium. The subsequent cell count produced the following results: 1.5×10⁷ cells per ml, 10 ml total volume, total number of cells: 1.5×10⁸. Since the cell count was not yet sufficient, 2.5 ml of the above cell suspension in 30 ml of the abovementioned medium were introduced into a 250 ml (75 cm²) flask (total 4 flasks). After 72 hours incubation time respectively 20 ml of fresh medium were introduced into the flasks. After the following 24 hour incubation there occurred a cell count as described above, which resulted in a total of 3.8×10⁸ cells. In order to reach the desired cell count of 2×10⁶ cells the cells were resuspended in 47.5 ml of the abovementioned medium in 4 flasks. After an incubation time of 24 hours the cells were centrifuged and twice washed with phosphate buffer without Ca²⁺ and Mg²⁺ (Biochrom AG).

The isolation of the total-RNA was carried out using the NucleoSpin RNA L Kit (Machery&Nagel) according to the instructions of the manufacturer. The above described procedure was repeated until the required cell count was achieved. This was necessary in order to reach the required amount of 6 mg total-RNA, which corresponded to a yield of 600 μg RNA per 10⁸ cells.

The general data for the patients could be seen from Table 2 and the preoperative data from Table 3.

TABLE 2 General clinical data General Data of the Patients Age [Years] 54.5 (7.75)¹ Sex [m/f] 16/6 Body Mass Index (BMI) [kg/m] 26 (4)¹  Number of the combined transplants (Kidney/Liver) 2 Number of transplants: Complete organ/Split LT: 22/0 ¹Values as medians and the values in parentesis represent the difference of the 75% - and 25%-percentile.

TABLE 3 Pre-operative Patient data Test results Units Data Prothrombin time [%] 67.5 (29.5) Leukocyte [Number/μl] 5350 (3925) Base deviation [mmol/l] −1 (5.1) Fibrinogen [μmol/l] 2.6 (2)   C-reaktive protein [mg/l] 14 (13) Creatinine [μmol/l]   81 (39.25) Thrombocytes [Number/μl]   100 (142.75) [×10³] Red bloodcells [Number/μl] 4 (1) Aspartate amino transferase [U/l] 1 (1) Alanine amino transferase [U/l] 1 (0) Direct bilirubin [μmol/l)]   12 (18.5) Total bilirubin [μmol/l]  32.5 (45.75) γ-Glutamyltransferase [U/l] 1 (1) Prothrombin ratio Ratio 1 (0) Partial prothrombin time [s] 33 (10) Albumin [g/l] 31 (13) Cholinesterase [U/l] 46 (23) Urea [mmol/l]   6 (3.5) Glucose [mmol/l] 6 (3) Lactate (max) [mmol/l] 1.9 (1)  

The intra-operative and post-operative data of the transplants are demonstrated in the following tables (Table 4; Table 5).

TABLE 4 Intraoperative Data of the patient cohort. Intraoperative Data Duration of liver ischaemia after the explanation [min] 289.5 (208.75) Duration of the surgery [min] 286.5 (128.75) Duration of the anhepatic phase [min]   40 (21.75) Blood products: Blood transfusion (EK/24 h [n]): 9.5 (6.75) Plasma transfusion (FFP/24 h [n]):   26 (27.25) Thrombocyte concentrate (TK/24 h [n]): 2 (0)  All values are given as medians and the values in parentesis represent the difference of the 75%- and 25%-percentile.

TABLE 5 Postoperative characterization of the patient cohort. Postoperative Data Stay in the Intensive Care Unit [Days]   6 (3.5) Stay in the hospital [Days] 26.5 (15) All values are given as medians and the values in parentesis represent the difference of the 75%- and 25%-percentile (quantile).

All patient samples were cohybridized on a microarray respectively with the reference sample.

Reverse Transcription/Marking/Hybridization

After collecting whole blood the total-RNA of the samples was isolated using the PAXGene Blood RNA Kit (PreAnalytiX) according to the instructions of the manufacturer and tested for their quality. From each sample 8 μg total-RNA were aliquoted and transcribed together with 10 μg total-RNA from SIGM5-cells as reference-RNA to complimentary DNA (cDNA) with reverse transcriptase Superscript II (Invitrogen) and the RNA subsequently removed from the preparation by alkaline hydrolysis. In the reaction preparation a part of the dTTP was replaced by aminoallyl-dUTP (AA-dUTP), in order later to make possible the coupling of the fluorescent dye to the cDNA.

After the purification of the reaction preparation with the cDNA of the samples and controls were covalently marked (dye swap) with the fluorescent dye DY-547 and DY-647 of the company Dyomics and hybridized on the microarray of the company SIRS-Lab. On the employed microarray there were 5308 immobilized polynucleotides with a length of 55-70 base pairs, with respectively represented one human gene and control spots for quality assurance. The microarray is subdivided into 28 subarrays with a grid of 15×15 spots.

The hybridization and the subsequent washing or, as the case may be, drying, was carried out in the hybridization station HS 400 (Tecan) according to the instructions of the manufacturer for 10.5 hours at 42° C. The employed hybridization solution was comprised of the respective labeled cDNA-samples, 3.5×SSC (1×SSC containing 150 mM sodium chloride and 15 mM sodium citrate), 0.3% sodium dodecyl sulfate (V/V) 25% formamide (V/V) and respectively 0.8 μg μl-1 cot-1 DNA, yeast t-RNA and poly-A RNA. The subsequent washing of the microarrays was carried out according to the following procedure at room temperature: respectively 90 second rinsing with wash buffer 1 (2×SSC, 0.03% sodium dodecyl sulfate), with wash buffer 2 (1×SSC) and subsequently with wash buffer 3 (0.2×SSC). Thereafter the microarrays were dried under a stream of nitrogen at a pressure of 2.5 bar at 30° C. over 150 seconds.

Evaluation

Following hybridization the hybridization signals of the microarrays were read out using a GenePix 4000B scanner (Axon) and the expression relationships of the differentially expressed genes determined with the software GenePix Pro 4.0 (Axon). For evaluation, the average intensity of the spot was determined as the median value for the associated spot pixel.

Correction of Systematic Errors:

The correction of systematic errors occurred according to the approach of Huber and others (Huber et al., 2003). Wherein the additive and the multiplicative bias within a microarray was estimated from 70% of the available gene samples. For all further computations the signals were transformed using arcus sinus hyberbolicus.

Biostatic Evaluation of Microarrays:

The goal of the data analysis was the extraction of gene expression patterns, which are characteristic for an operational intervention in a liver transplant. Building on the work of Tomic among others (Tomic V., et al., 2005) the analysis was carried out in three steps:

1. Step: In the data analysis those gene samples were included of which the signals were measured with sufficient intensity. Therein the average spot quality was evaluated within the total experiment. Thereafter 4176 samples were considered in the analysis. The resulting data matrix contained approximately 2.3% missing values, which were replaced by estimated values (compare Toyanskaya among others (Troyanskaya, et al., 2001)). 2. Step: Utilizing a suitable statistical test, genes were identified, which changed in similar manner in all patients due to the transplantation. For this, gene for gene, the multivariant single entry sample PC-test according to Laeuter (Laeuter, 1996) was employed, which forms a generalization of the simple t-test. As a result each gene was assigned a p-value, which reflected or represented the statistical difference in the time variation of the expression of the respective gene. In order to determine a threshold of significance, which makes possible a selection of differentially expressed genes, the concept of Storey and Tibshirani was selected (Storey and Tibshirani, 2003). Therein the proportion of the false positive decisions (in English false discovery rate) was estimated with the aid of the so-called q-value. 532 samples with a q-value smaller than 0.05 were inclusion criteria for the final gene list. The threshold was so defined, that an optimal relationship of the discovered significant genes to the associated proportion of the false positives was achieved. According to this evaluation the final list contained approximately 5% (˜26 of 532) false positive samples. 3. Step: In the statistical comparison genes were identified, which as a result of the transplantation were significantly changed in the same manner in all patients. In order to obtain characteristic patterns of the gene expression, the results of the selected 532 expressed genes were arranged with the aid of a hierarchical cluster algorithm and presented in a corresponding pattern. In the cluster algorithm the correlation was selected as the distance dimension. The “average linkage”—methodology served as the basis for the establishment of the associated dendrogram. In the representation of the associated gene cluster the similarities of the expression behavior of particular genes between individual samples was displayed FIG. 1. The tabulated list of the genes with the corresponding average expression values were compiled in Tables 6-9.

In the gene cluster a distribution of the genes in four similar gene groups with differentiated expressed gene expressions were discovered, which exhibited the following biologic interpretable expression changes:

The first group of 132 gene samples, which did not have or had only slightly relationship to the operation, which were expressed following the third or as the case may be the seventh postoperative day (Table 6).

The second group of the 221 gene samples, which reacted with early postoperative elevated gene expressions, reverted after 14 days almost completely to the original gene expression level (Table 7).

The third group of 57 gene samples, which reacted to the transplantation with a small expression magnitude beginning at the third postoperative day (Table 8).

The fourth cluster included approximately 122 genes, which were distributed in counterflow in the second cluster and exhibited a reduced expression after the first postoperative day. Thereafter however an increasing gene activity was to be recognized, which however did not return to the preoperative value after 14 days (Table 9).

Typical representations with specific expression plots are shown in FIG. 2.

TABLE 6 Cluster 1 Sequence PC-Test Median (±Standard deviation) No. p-value q-value t0 t0 post t3 post t7 post t14 post 1 0.01 0.05 0.14 (±0.37) 0.48 (±0.59) 0.14 (±0.54) 0.27 (±0.32) 0.46 (±0.45) 2 0.00 0.02 −0.11 (±0.24) 0.15 (±0.21) −0.09 (±0.22) −0.05 (±0.24) −0.05 (±0.23) 3 0.01 0.03 0 (±0.35) 0.02 (±0.31) 0.3 (±0.47) 0.24 (±0.35) 0.27 (±0.42) 4 0.01 0.05 2.01 (±0.56) 1.97 (±0.48) 2.14 (±0.38) 1.69 (±0.7) 2.16 (±0.43) 5 0.01 0.03 1.72 (±0.49) 1.78 (±0.5) 1.83 (±0.48) 1.45 (±0.65) 1.94 (±0.43) 6 0.01 0.03 0.54 (±0.27) 0.57 (±0.3) 0.62 (±0.26) 0.53 (±0.31) 0.74 (±0.28) 7 0.00 0.00 0.47 (±0.24) 0.93 (±0.39) 0.67 (±0.36) 0.82 (±0.36) 0.94 (±0.39) 8 0.01 0.05 −0.22 (±0.35) −0.28 (±0.36) −0.29 (±0.4) 0 (±0.65) 0.11 (±0.57) 9 0.00 0.02 −0.94 (±0.43) −0.6 (±0.34) −0.63 (±0.39) −0.56 (±0.47) −0.7 (±0.46) 10 0.00 0.00 −0.75 (±0.62) −0.41 (±0.57) −0.4 (±0.43) −0.35 (±0.41) −0.83 (±0.52) 11 0.00 0.01 −0.55 (±0.2) −0.36 (±0.21) −0.52 (±0.23) −0.41 (±0.27) −0.56 (±0.27) 12 0.00 0.00 −0.1 (±0.24) −0.03 (±0.29) 0.28 (±0.32) 0.01 (±0.36) 0.15 (±0.27) 13 0.00 0.01 −0.05 (±0.28) 0.05 (±0.32) 0.24 (±0.35) −0.04 (±0.25) 0.22 (±0.35) 14 0.00 0.01 0.18 (±0.32) −0.13 (±0.43) 0.13 (±0.38) 0.5 (±0.41) 0.22 (±0.44) 15 0.00 0.00 −1.29 (±0.46) −1.82 (±0.4) −1.49 (±0.39) −1.2 (±0.31) −1.61 (±0.33) 16 0.00 0.03 −0.04 (±0.41) −0.33 (±0.56) 0.13 (±0.52) 0.14 (±0.39) 0.06 (±0.46) 17 0.00 0.00 0.17 (±0.33) −0.21 (±0.34) −0.26 (±0.28) 0.04 (±0.35) −0.04 (±0.29) 18 0.00 0.01 −0.35 (±0.33) −0.5 (±0.2) −0.25 (±0.22) −0.17 (±0.24) −0.25 (±0.29) 19 0.00 0.01 −0.14 (±0.45) −0.41 (±0.42) −0.11 (±0.26) −0.07 (±0.25) −0.02 (±0.25) 20 0.00 0.02 −0.85 (±0.35) −0.85 (±0.24) −0.75 (±0.18) −0.64 (±0.21) −0.65 (±0.3) 21 0.01 0.04 −1.15 (±0.53) −0.94 (±0.33) −0.9 (±0.3) −0.66 (±0.32) −0.86 (±0.34) 22 0.01 0.04 −0.65 (±0.3) −0.76 (±0.27) −0.64 (±0.24) −0.48 (±0.28) −0.57 (±0.27) 23 0.01 0.04 −0.38 (±0.3) −0.66 (±0.19) −0.5 (±0.18) −0.41 (±0.21) −0.49 (±0.4) 24 0.01 0.04 −0.64 (±0.57) −0.72 (±0.44) −0.55 (±0.45) −0.27 (±0.41) −0.39 (±0.49) 25 0.01 0.04 −0.75 (±0.3) −0.97 (±0.27) −0.84 (±0.31) −0.69 (±0.2) −0.76 (±0.24) 26 0.01 0.04 −1.08 (±0.34) −1.39 (±0.21) −1.35 (±0.34) −1.22 (±0.35) −1.29 (±0.42) 27 0.00 0.00 −0.29 (±0.27) −0.56 (±0.19) −0.46 (±0.26) −0.27 (±0.18) −0.31 (±0.3) 28 0.00 0.00 −1.88 (±0.32) −2.16 (±0.24) −2.11 (±0.25) −1.91 (±0.3) −1.94 (±0.27) 29 0.00 0.02 −0.68 (±0.31) −0.87 (±0.27) −0.87 (±0.32) −0.64 (±0.17) −0.71 (±0.29) 30 0.00 0.00 −1.07 (±0.41) −1.48 (±0.44) −1.21 (±0.4) −0.89 (±0.28) −1.1 (±0.48) 31 0.00 0.00 −0.76 (±0.42) −1.01 (±0.3) −0.93 (±0.36) −0.53 (±0.26) −0.6 (±0.57) 32 0.00 0.02 −0.28 (±0.26) −0.38 (±0.37) −0.16 (±0.31) −0.07 (±0.24) −0.09 (±0.34) 33 0.01 0.04 −0.05 (±0.38) −0.14 (±0.2) −0.07 (±0.25) 0.04 (±0.16) 0.02 (±0.33) 34 0.00 0.03 −0.14 (±0.35) −0.34 (±0.31) −0.13 (±0.34) −0.04 (±0.26) 0.1 (±0.3) 35 0.00 0.00 0.23 (±0.3) 0.33 (±0.41) 0.43 (±0.42) 0.63 (±0.4) 0.7 (±0.41) 36 0.00 0.02 −0.84 (±0.34) −0.9 (±0.24) −0.77 (±0.26) −0.72 (±0.2) −0.66 (±0.28) 37 0.00 0.02 0.9 (±0.57) 1.17 (±0.44) 1.38 (±0.39) 1.28 (±0.53) 1.49 (±0.56) 38 0.00 0.03 0.25 (±0.36) 0.27 (±0.24) 0.4 (±0.24) 0.46 (±0.19) 0.43 (±0.31) 39 0.00 0.02 −0.33 (±0.43) −0.51 (±0.44) −0.24 (±0.44) −0.06 (±0.41) −0.1 (±0.3) 40 0.00 0.01 −0.61 (±0.32) −0.73 (±0.3) −0.61 (±0.32) −0.29 (±0.37) −0.46 (±0.36) 41 0.01 0.03 −0.63 (±0.25) −0.62 (±0.18) −0.55 (±0.29) −0.42 (±0.29) −0.44 (±0.33) 42 0.01 0.04 −2.27 (±0.18) −2.35 (±0.21) −2.37 (±0.22) −2.14 (±0.23) −2.16 (±0.29) 43 0.00 0.01 −0.45 (±0.38) −0.49 (±0.33) −0.26 (±0.55) −0.18 (±0.38) −0.01 (±0.56) 44 0.00 0.01 −0.36 (±0.21) −0.28 (±0.16) −0.18 (±0.29) −0.14 (±0.25) −0.05 (±0.28) 45 0.01 0.04 −0.07 (±0.35) −0.02 (±0.33) 0.05 (±0.37) 0.13 (±0.38) 0.24 (±0.39) 46 0.00 0.01 0.18 (±0.29) 0.24 (±0.23) 0.36 (±0.39) 0.39 (±0.34) 0.49 (±0.28) 47 0.00 0.02 −0.07 (±0.32) −0.25 (±0.35) 0.01 (±0.4) 0.04 (±0.37) 0.16 (±0.31) 48 0.00 0.03 −0.34 (±0.45) −0.27 (±0.37) −0.1 (±0.27) −0.02 (±0.27) −0.03 (±0.24) 49 0.00 0.00 −1.23 (±0.38) −1.27 (±0.33) −1.2 (±0.41) −0.89 (±0.39) −0.82 (±0.56) 50 0.00 0.02 −1.02 (±0.27) −1.28 (±0.32) −1.09 (±0.28) −0.92 (±0.27) −0.93 (±0.38) 51 0.00 0.00 −0.36 (±0.31) −0.69 (±0.27) −0.59 (±0.35) −0.44 (±0.31) −0.3 (±0.39) 52 0.00 0.01 −0.1 (±0.32) −0.19 (±0.39) −0.05 (±0.33) 0.07 (±0.27) 0.14 (±0.3) 53 0.01 0.04 0.5 (±0.4) 0.4 (±0.53) 0.68 (±0.43) 0.65 (±0.29) 0.78 (±0.47) 54 0.01 0.05 −0.44 (±0.3) −0.57 (±0.31) −0.42 (±0.36) −0.32 (±0.28) −0.26 (±0.31) 55 0.00 0.00 −0.02 (±0.36) 0.09 (±0.29) 0.18 (±0.26) 0.26 (±0.25) 0.34 (±0.23) 56 0.00 0.02 −0.68 (±0.55) −0.65 (±0.41) −0.52 (±0.44) −0.32 (±0.35) −0.39 (±0.38) 57 0.00 0.02 −0.17 (±0.25) −0.42 (±0.34) −0.16 (±0.28) −0.07 (±0.29) −0.07 (±0.21) 58 0.01 0.03 0.26 (±0.38) 0.2 (±0.31) 0.38 (±0.34) 0.47 (±0.35) 0.52 (±0.37) 59 0.00 0.00 −0.45 (±0.51) −0.47 (±0.55) −0.16 (±0.39) 0.15 (±0.44) 0.27 (±0.45) 60 0.00 0.02 −0.16 (±0.48) −0.28 (±0.47) 0.05 (±0.34) 0.28 (±0.48) 0.28 (±0.52) 61 0.00 0.00 −0.23 (±0.45) −0.26 (±0.35) −0.05 (±0.35) 0.15 (±0.32) 0.11 (±0.4) 62 0.00 0.00 −0.94 (±0.44) −1.05 (±0.27) −0.82 (±0.36) −0.57 (±0.35) −0.66 (±0.35) 63 0.01 0.05 −1.01 (±0.41) −1.06 (±0.37) −0.98 (±0.35) −0.73 (±0.34) −0.85 (±0.39) 64 0.00 0.00 −0.84 (±0.46) −1.02 (±0.49) −0.82 (±0.49) −0.46 (±0.44) −0.53 (±0.45) 65 0.00 0.00 −0.81 (±0.66) −0.86 (±0.7) −0.58 (±0.62) −0.27 (±0.59) −0.33 (±0.63) 66 0.00 0.01 −0.88 (±0.63) −0.92 (±0.62) −0.68 (±0.6) −0.45 (±0.55) −0.51 (±0.6) 67 0.00 0.00 −1.06 (±0.51) −1.18 (±0.49) −0.93 (±0.52) −0.66 (±0.53) −0.61 (±0.62) 68 0.00 0.01 −1.11 (±0.34) −1.18 (±0.3) −1.05 (±0.38) −0.83 (±0.42) −0.87 (±0.39) 69 0.00 0.02 −0.18 (±0.52) −0.33 (±0.41) −0.12 (±0.5) 0.03 (±0.38) 0.18 (±0.59) 70 0.00 0.01 0.08 (±0.6) 0 (±0.3) 0.23 (±0.44) 0.4 (±0.42) 0.5 (±0.46) 71 0.00 0.01 −0.67 (±0.38) −0.68 (±0.39) −0.56 (±0.41) −0.35 (±0.36) −0.36 (±0.41) 72 0.00 0.00 0.57 (±0.79) 0.54 (±0.79) 1.16 (±1.04) 1.42 (±0.84) 1.81 (±0.86) 73 0.00 0.00 −0.32 (±0.84) −0.5 (±0.75) 0.07 (±0.95) 0.41 (±0.77) 0.62 (±0.81) 74 0.00 0.01 −0.49 (±0.5) −0.4 (±0.49) −0.2 (±0.33) 0.04 (±0.43) 0.02 (±0.55) 75 0.00 0.01 0.23 (±0.56) 0.09 (±0.59) 0.33 (±0.48) 0.66 (±0.49) 0.61 (±0.59) 76 0.00 0.00 −0.05 (±0.66) −0.16 (±0.63) 0.1 (±0.56) 0.34 (±0.43) 0.56 (±0.64) 77 0.00 0.03 −0.33 (±0.48) −0.51 (±0.44) −0.28 (±0.54) −0.11 (±0.39) −0.05 (±0.39) 78 0.00 0.01 −0.71 (±0.52) −0.77 (±0.57) −0.59 (±0.45) −0.3 (±0.36) −0.38 (±0.43) 79 0.00 0.00 −1.81 (±0.46) −2.02 (±0.44) −1.83 (±0.35) −1.54 (±0.48) −1.56 (±0.54) 80 0.00 0.00 −2.04 (±0.54) −2.39 (±0.51) −2.1 (±0.43) −1.74 (±0.59) −1.69 (±0.6) 81 0.00 0.01 −0.02 (±0.21) 0.02 (±0.29) 0.13 (±0.3) 0.15 (±0.24) 0.26 (±0.21) 82 0.00 0.00 −0.3 (±0.33) −0.44 (±0.35) −0.44 (±0.34) 0.05 (±0.43) 0.04 (±0.48) 83 0.00 0.00 0.78 (±0.42) 0.74 (±0.31) 0.9 (±0.43) 1.12 (±0.53) 1.2 (±0.49) 84 0.01 0.03 0.36 (±0.38) 0.36 (±0.37) 0.41 (±0.51) 0.53 (±0.56) 0.72 (±0.43) 85 0.00 0.01 0.55 (±0.48) 0.72 (±0.46) 0.89 (±0.45) 0.93 (±0.51) 1.1 (±0.6) 86 0.00 0.01 1.24 (±0.53) 1.21 (±0.47) 1.43 (±0.47) 1.47 (±0.39) 1.57 (±0.47) 87 0.00 0.00 1.17 (±0.45) 1.28 (±0.49) 1.51 (±0.56) 1.4 (±0.57) 1.7 (±0.55) 88 0.00 0.02 1.45 (±0.74) 1.45 (±0.62) 1.9 (±0.61) 1.69 (±0.72) 1.96 (±0.76) 89 0.00 0.00 −0.08 (±0.34) 0.01 (±0.23) 0.14 (±0.26) 0.18 (±0.33) 0.27 (±0.31) 90 0.01 0.03 −1.8 (±0.57) −2.21 (±0.39) −1.99 (±0.31) −1.9 (±0.41) −1.9 (±0.55) 91 0.00 0.01 −1.04 (±0.41) −1.39 (±0.19) −1.22 (±0.24) −1.1 (±0.38) −1.01 (±0.44) 92 0.00 0.02 0.03 (±0.45) 0.08 (±0.49) 0.06 (±0.44) 0.39 (±0.51) 0.42 (±0.39) 93 0.01 0.05 0.11 (±0.33) −0.02 (±0.56) −0.21 (±0.71) 0 (±0.43) 0.21 (±0.41) 94 0.00 0.02 0.09 (±0.55) −0.21 (±0.47) 0.2 (±0.54) −0.24 (±0.56) −0.18 (±0.44) 95 0.01 0.04 0.15 (±0.81) −0.29 (±0.57) −0.45 (±0.56) −0.22 (±0.44) 0.15 (±0.73) 96 0.01 0.05 −1.13 (±0.35) −1.44 (±0.34) −1.44 (±0.35) −1.2 (±0.41) −1.1 (±0.69) 97 0.00 0.02 −0.24 (±0.48) −0.63 (±0.41) −0.57 (±0.48) −0.35 (±0.34) −0.29 (±0.26) 98 0.00 0.01 −0.12 (±0.43) 0.16 (±0.35) 0.09 (±0.46) −0.16 (±0.39) 0.2 (±0.44) 99 0.00 0.02 0.06 (±0.29) 0.02 (±0.39) 0.16 (±0.36) 0.26 (±0.26) 0.3 (±0.28) 100 0.00 0.01 −0.33 (±0.26) −0.27 (±0.24) −0.26 (±0.25) −0.02 (±0.19) −0.21 (±0.2) 101 0.00 0.00 0.99 (±0.61) 0.98 (±0.81) 1.37 (±0.65) 1.95 (±0.79) 1.8 (±0.56) 102 0.00 0.00 0.84 (±0.35) 0.92 (±0.33) 1.2 (±0.3) 1.15 (±0.3) 1.1 (±0.23) 103 0.00 0.00 −1.94 (±0.31) −1.92 (±0.31) −2.12 (±0.27) −1.49 (±0.43) −1.66 (±0.46) 104 0.00 0.00 −2.21 (±0.66) −2.4 (±0.52) −1.79 (±0.8) −0.24 (±0.93) −1.38 (±0.66) 105 0.00 0.00 −2.85 (±0.49) −2.88 (±0.42) −2.44 (±0.68) −1.38 (±0.84) −2.34 (±0.7) 106 0.00 0.00 0.53 (±1.01) 0.83 (±0.93) 1.48 (±0.96) 2.59 (±1.1) 1.44 (±0.91) 107 0.00 0.00 −0.15 (±0.28) −0.11 (±0.31) −0.04 (±0.25) 0.22 (±0.22) 0.11 (±0.25) 108 0.00 0.00 −0.2 (±0.58) 0.25 (±0.71) 0.41 (±0.46) 1.45 (±0.54) 1.29 (±0.51) 109 0.00 0.00 3.42 (±0.62) 3.9 (±0.66) 3.92 (±0.46) 4.6 (±0.77) 4.61 (±0.73) 110 0.00 0.00 3.82 (±0.7) 4.3 (±0.77) 4.33 (±0.59) 4.89 (±0.69) 5.08 (±0.73) 111 0.00 0.00 2.61 (±0.79) 2.89 (±0.9) 2.94 (±0.99) 3.79 (±1.04) 4.05 (±0.86) 112 0.00 0.00 1.14 (±0.69) 1.45 (±0.85) 1.51 (±0.64) 2.48 (±0.6) 2.49 (±0.55) 113 0.00 0.00 −0.11 (±0.45) −0.28 (±0.51) −0.06 (±0.46) 0.56 (±0.69) 0.25 (±0.5) 114 0.00 0.00 1.27 (±0.61) 1.59 (±0.59) 1.57 (±0.44) 2.17 (±0.61) 2.2 (±0.57) 115 0.00 0.00 0.28 (±0.62) 0.53 (±0.74) 0.66 (±0.53) 1.16 (±0.6) 1.12 (±0.82) 116 0.00 0.00 2.3 (±0.68) 2.73 (±0.72) 2.77 (±0.64) 3.22 (±0.84) 3.19 (±0.63) 117 0.00 0.00 1.09 (±0.59) 1.31 (±0.63) 1.34 (±0.54) 1.84 (±0.7) 1.84 (±0.61) 118 0.01 0.04 0.18 (±0.25) −0.02 (±0.4) −0.21 (±0.34) 0.13 (±0.3) 0.12 (±0.42) 119 0.00 0.01 −0.47 (±0.35) −0.33 (±0.37) −0.69 (±0.43) −0.33 (±0.32) −0.55 (±0.3) 120 0.00 0.01 −0.13 (±0.36) 0.09 (±0.31) −0.04 (±0.26) 0.2 (±0.22) 0.07 (±0.24) 121 0.00 0.00 0.36 (±0.52) 0.63 (±0.49) 0.38 (±0.45) 0.84 (±0.43) 0.44 (±0.33) 122 0.00 0.01 0.4 (±0.48) 0.61 (±0.47) 0.41 (±0.41) 0.77 (±0.62) 0.35 (±0.33) 123 0.00 0.00 0.5 (±0.41) 0.87 (±0.48) 0.53 (±0.51) 0.95 (±0.5) 0.63 (±0.38) 124 0.01 0.04 0.95 (±0.53) 1.3 (±0.62) 0.98 (±0.58) 1.5 (±0.68) 1.24 (±0.45) 125 0.00 0.00 0.24 (±0.37) 0.52 (±0.3) 0.58 (±0.25) 0.66 (±0.38) 0.5 (±0.3) 126 0.00 0.00 −0.26 (±0.42) −0.18 (±0.36) 0.28 (±0.48) 0.05 (±0.38) −0.1 (±0.59) 127 0.00 0.01 −1.87 (±0.37) −2.08 (±0.37) −1.82 (±0.33) −1.6 (±0.44) −1.65 (±0.32) 128 0.00 0.01 0.34 (±0.37) 0.33 (±0.3) 0.51 (±0.36) 0.83 (±0.45) 0.6 (±0.31) 129 0.00 0.02 0.05 (±0.16) 0.21 (±0.31) 0.06 (±0.24) 0.21 (±0.21) −0.05 (±0.22) 130 0.01 0.04 −0.64 (±0.51) −0.36 (±0.39) −0.36 (±0.45) −0.23 (±0.34) −0.46 (±0.46) 131 0.01 0.05 0.19 (±0.4) 0.17 (±0.33) 0.54 (±0.71) 0.47 (±0.59) 0.28 (±0.45) 132 0.00 0.02 −0.03 (±0.18) 0.14 (±0.17) 0.18 (±0.22) 0.06 (±0.19) 0.05 (±0.17)

TABLE 7 Cluster 2 Sequence PC-Test Median (±Standard deviation) No. p-value q-value t0 t0 post t3 post t7 post t14 post 133 0.00 0.00 −0.42 (±0.32) 0.41 (±0.36) 0.02 (±0.39) 0.01 (±0.42) −0.07 (±0.38) 134 0.00 0.00 0.02 (±0.31) 0.46 (±0.34) 0.26 (±0.23) 0.12 (±0.34) 0.24 (±0.22) 135 0.00 0.01 0.05 (±0.42) 0.36 (±0.22) 0.24 (±0.41) 0 (±0.38) 0.13 (±0.35) 136 0.01 0.04 −0.1 (±0.23) −0.04 (±0.21) −0.2 (±0.26) −0.17 (±0.21) −0.3 (±0.36) 137 0.00 0.01 −0.23 (±0.35) 0.02 (±0.41) 0.11 (±0.33) −0.05 (±0.3) −0.2 (±0.49) 138 0.01 0.04 0.02 (±0.43) −0.24 (±0.38) −0.07 (±0.29) 0.12 (±0.34) −0.19 (±0.44) 139 0.00 0.00 0.01 (±0.48) 1.4 (±0.92) 0.58 (±0.56) 0.61 (±0.67) 0.5 (±0.77) 140 0.01 0.03 −0.06 (±0.29) 0.13 (±0.28) 0.13 (±0.29) −0.1 (±0.22) −0.06 (±0.25) 141 0.01 0.04 0.34 (±0.53) 0.91 (±0.79) 0.83 (±0.69) 0.13 (±0.66) 0.26 (±0.85) 142 0.01 0.03 −0.28 (±0.31) −0.1 (±0.3) −0.16 (±0.27) −0.3 (±0.27) −0.38 (±0.36) 143 0.00 0.02 −0.71 (±0.27) −0.49 (±0.27) −0.63 (±0.34) −0.7 (±0.3) −0.74 (±0.24) 144 0.00 0.00 −1.01 (±0.31) −0.55 (±0.3) −0.87 (±0.37) −0.92 (±0.22) −0.98 (±0.3) 145 0.00 0.00 −0.16 (±0.23) −0.01 (±0.2) −0.06 (±0.32) −0.29 (±0.24) −0.25 (±0.28) 146 0.00 0.00 −0.13 (±0.42) 0.48 (±0.51) 0.18 (±0.7) −0.01 (±0.4) −0.18 (±0.48) 147 0.00 0.03 −0.24 (±0.53) 0.03 (±0.53) −0.02 (±0.43) −0.06 (±0.42) −0.29 (±0.56) 148 0.00 0.02 −0.11 (±0.47) −0.1 (±0.35) 0.25 (±0.29) 0.16 (±0.4) 0.11 (±0.38) 149 0 01 0.04 −0.69 (±0.4) −0.46 (±0.25) −0.54 (±0.3) −0.64 (±0.27) −0.72 (±0.31) 150 0.00 0.00 −0.23 (±0.27) −0.14 (±0.28) −0.09 (±0.22) −0.03 (±0.18) −0.36 (±0.35) 151 0.00 0.00 −0.59 (±0.36) −0.06 (±0.3) −0.36 (±0.27) −0.32 (±0.28) −0.55 (±0.27) 152 0.01 0.04 −0.12 (±0.27) 0.16 (±0.37) 0.09 (±0.26) 0.17 (±0.32) 0.04 (±0.23) 153 0.00 0.01 0.97 (±0.6) 1.41 (±0.8) 1.3 (±0.63) 0.85 (±0.63) 1.43 (±0.55) 154 0.00 0.00 0.98 (±0.39) 1.4 (±0.55) 1.22 (±0.51) 0.91 (±0.5) 1.28 (±0.51) 155 0.00 0.00 0.45 (±0.42) 0.89 (±0.52) 0.6 (±0.29) 0.53 (±0.27) 0.85 (±0.51) 156 0.00 0.00 0.27 (±0.44) 0.85 (±0.47) 0.6 (±0.3) 0.29 (±0.42) 0.46 (±0.42) 157 0.01 0.03 0.27 (±0.49) 0.52 (±0.53) 0.75 (±0.53) 0.53 (±0.63) 0.45 (±0.47) 158 0.00 0.00 −0.04 (±0.19) 0.26 (±0.26) 0.16 (±0.36) 0.07 (±0.25) 0.07 (±0.28) 159 0.00 0.00 −0.04 (±0.32) 0.55 (±0.28) 0.34 (±0.32) 0.09 (±0.4) 0.02 (±0.29) 160 0.00 0.01 −0.07 (±0.2) 0.2 (±0.28) 0.07 (±0.31) −0.01 (±0.33) −0.24 (±0.3) 161 0.00 0.00 0.95 (±0.48) 1.15 (±0.66) 1.71 (±0.59) 1.15 (±0.62) 0.9 (±0.44) 162 0.01 0.05 1.75 (±0.44) 2.03 (±0.73) 1.95 (±0.64) 1.58 (±0.62) 1.33 (±0.81) 163 0.01 0.03 0.69 (±0.36) 0.71 (±0.5) 1.03 (±0.51) 0.62 (±0.36) 0.47 (±0.32) 164 0.00 0.02 0.69 (±0.48) 0.79 (±0.51) 1.05 (±0.59) 0.61 (±0.39) 0.46 (±0.45) 165 0.01 0.03 0.82 (±0.48) 1.36 (±0.54) 1.21 (±0.5) 1.19 (±0.53) 1.09 (±0.37) 166 0.00 0.00 0.29 (±0.58) 1.27 (±0.64) 0.74 (±0.71) 0.85 (±0.54) 0.5 (±0.6) 167 0.00 0.00 1.67 (±1.13) 3.13 (±1.04) 2.75 (±1.08) 2.21 (±0.92) 2.29 (±1) 168 0.00 0.00 0.31 (±0.61) 2.11 (±1) 1.25 (±0.92) 1.16 (±0.67) 1.15 (±0.96) 169 0.00 0.03 0.7 (±0.63) 2.64 (±0.97) 1.63 (±1) 1.66 (±1) 1.72 (±1.04) 170 0.00 0.01 0.61 (±0.66) 1.34 (±0.49) 0.89 (±0.44) 0.74 (±0.54) 0.66 (±0.38) 171 0.00 0.00 0.95 (±0.76) 1.95 (±0.64) 1.68 (±1.28) 1.34 (±0.73) 1.22 (±0.7) 172 0.01 0.03 0.43 (±0.75) 1.31 (±0.79) 0.87 (±0.72) 0.63 (±0.58) 0.79 (±0.6) 173 0.00 0.00 1 (±0.66) 2.08 (±0.8) 2.15 (±0.64) 1.54 (±1) 1.35 (±0.54) 174 0.00 0.01 −0.55 (±0.41) −0.22 (±0.4) −0.44 (±0.48) −0.52 (±0.27) −0.69 (±0.27) 175 0.01 0.04 0.04 (±0.29) 0.2 (±0.23) 0.22 (±0.27) 0.21 (±0.26) 0.05 (±0.23) 176 0.00 0.03 −0.22 (±0.39) 0.07 (±0.34) 0.06 (±0.36) −0.05 (±0.38) −0.17 (±0.37) 177 0.01 0.03 −0.24 (±0.42) −0.14 (±0.31) −0.14 (±0.42) −0.26 (±0.41) −0.42 (±0.37) 178 0.00 0.00 −0.13 (±0.45) −0.14 (±0.32) 0.17 (±0.43) 0.19 (±0.36) −0.17 (±0.39) 179 0.00 0.02 −0.17 (±0.5) −0.18 (±0.35) 0.13 (±0.36) 0.07 (±0.38) ±0.15 (±0.37) 180 0.00 0.02 −0.49 (±0.33) −0.29 (±0.38) −0.15 (±0.37) −0.2 (±0.35) −0.48 (±0.31) 181 0.01 0.04 −0.23 (±0.42) 0.09 (±0.42) 0.09 (±0.43) 0.07 (±0.34) −0.02 (±0.38) 182 0.00 0.01 −0.06 (±0.56) 0.67 (±0.42) 0.5 (±0.47) 0.39 (±0.4) 0.47 (±0.51) 183 0.00 0.00 0.3 (±0.59) 0.7 (±0.63) 1.08 (±0.64) 1.13 (±0.34) 0.94 (±0.59) 184 0.01 0.04 −0.09 (±0.32) 0.18 (±0.3) 0.21 (±0.29) 0.2 (±0.37) 0.12 (±0.22) 185 0.01 0.05 −0.07 (±0.44) −0.11 (±0.25) 0.06 (±0.23) 0.1 (±0.17) 0.66 (±0.24) 186 0.00 0.00 0.1 (±0.46) 0.33 (±0.3) 0.51 (±0.32) 0.55 (±0.23) 0.5 (±0.36) 187 0.00 0.02 0.33 (±0.39) 1.28 (±0.66) 0.76 (±0.84) 0.62 (±0.56) 0.67 (±0.46) 188 0.00 0.03 −0.27 (±0.52) 0.42 (±0.47) 0.23 (±0.39) 0.25 (±0.38) 0.06 (±0.49) 189 0.00 0.00 0.74 (±0.46) 1.71 (±0.38) 1.36 (±0.49) 0.94 (±0.55) 0.8 (±0.54) 190 0.00 0.00 −0.15 (±0.35) 0.42 (±0.46) 0.14 (±0.39) 0.15 (±0.28) −0.01 (±0.33) 191 0.00 0.01 −0.82 (±0.27) −0.32 (±0.33) −0.65 (±0.27) −0.5 (±0.17) −0.57 (±0.31) 192 0.00 0.00 0.05 (±0.31) 0.49 (±0.34) 0.2 (±0.24) 0.23 (±0.3) 0.04 (±0.31) 193 0.00 0.00 −0.19 (±0.48) 1.01 (±0.64) −0.16 (±0.49) 0.45 (±0.47) −0.08 (±0.42) 194 0.00 0.00 −0.59 (±0.38) 0.01 (±0.41) −0.35 (±0.36) −0.44 (±0.35) −0.54 (±0.44) 195 0.00 0.01 ±0.43 (±0.43) 0.13 (±0.57) −0.13 (±0.37) −0.17 (±0.34) −0.27 (±0.51) 196 0.00 0.00 0.76 (±0.55) 1.48 (±0.47) 1.48 (±0.49) 1.26 (±0.49) 1.15 (±0.46) 197 0.00 0.00 0.68 (±0.43) 1.22 (±0.49) 1.15 (±0.32) 0.94 (±0.36) 0.99 (±0.39) 198 0.00 0.00 −0.54 (±0.36) −0.07 (±0.52) −0.24 (±0.51) −0.59 (±0.51) −0.85 (±0.46) 199 0.00 0.00 0.31 (±0.43) 0.92 (±0.48) 0.63 (±0.49) 0.78 (±0.48) 0.21 (±0.5) 200 0.00 0.01 −0.49 (±0.41) 0.12 (±0.47) −0.07 (±0.35) −0.05 (±0.26) −0.18 (±0.2) 201 0.00 0.00 0.09 (±0.53) 1.05 (±0.81) 0.79 (±0.56) 0.76 (±0.6) 0.54 (±0.58) 202 0.00 0.00 −0.46 (±0.31) 0.2 (±0.44) −0.03 (±0.47) −0.26 (±0.37) −0.32 (±0.4) 203 0.00 0.01 −1.76 (±0.32) −1.48 (±0.31) −1.57 (±0.28) −1.44 (±0.3) −1.76 (±0.26) 204 0.00 0.00 0.99 (±0.55) 1.43 (±0.43) 1.13 (±0.52) 1.4 (±0.52) 0.99 (±0.51) 205 0.00 0.02 −0.64 (±0.37) −0.34 (±0.38) −0.53 (±0.31) −0.39 (±0.31) −0.6 (±0.34) 206 0.00 0.02 0.13 (±0.38) 0.58 (±0.42) 0.28 (±0.37) 0.36 (±0.37) 0.12 (±0.44) 207 0.00 0.00 −0.28 (±0.36) 0.17 (±0.35) −0.02 (±0.33) 0.07 (±0.32) −0.08 (±0.43) 208 0.00 0.00 −0.45 (±0.33) 0.54 (±0.52) 0.01 (±0.24) −0.01 (±0.3) −0.15 (±0.6) 209 0.00 0.00 0.16 (±0.46) 2.08 (±0.83) 0.89 (±0.79) 0.76 (±0.68) 0.37 (±0.63) 210 0.00 0.00 −0.83 (±0.43) −0.18 (±0.35) −0.59 (±0.37) −0.51 (±0.29) −0.73 (±0.34) 211 0.00 0.00 0.18 (±0.41) 1.27 (±0.55) 0.79 (±0.43) 0.74 (±0.47) 0.64 (±0.52) 212 0.00 0.00 0.94 (±0.41) 2.1 (±0.42) 1.55 (±0.43) 1.39 (±0.36) 1.47 (±0.49) 213 0.00 0.00 −0.57 (±0.44) 0.47 (±0.36) −0.03 (±0.34) 0.05 (±0.35) −0.12 (±0.43) 214 0.00 0.00 0.75 (±0.44) 1.67 (±0.45) 1.4 (±0.55) 1.34 (±0.53) 1.2 (±0.62) 215 0.00 0.00 2.08 (±0.7) 4.79 (±0.58) 4.01 (±0.68) 3.9 (±1.1) 3.54 (±0.97) 216 0.00 0.00 0.49 (±0.53) 2.08 (±0.63) 1.28 (±0.58) 1.27 (±0.58) 1.01 (±0.7) 217 0.00 0.00 0.81 (±0.77) 2.53 (±0.92) 1.4 (±0.74) 1.73 (±0.64) 1.23 (±0.57) 218 0.00 0.00 0.24 (±0.33) 1.06 (±0.4) 0.61 (±0.49) 0.63 (±0.42) 0.27 (±0.38) 219 0.00 0.00 −0.89 (±0.43) 0.57 (±0.49) −0.03 (±0.46) −0.33 (±0.32) −0.71 (±0.28) 220 0.00 0.00 −0.11 (±0.31) 1.04 (±0.52) 0.43 (±0.39) 0.19 (±0.38) 0.05 (±0.42) 221 0.00 0.00 0.78 (±0.65) 1.76 (±0.52) 1 (±0.47) 0.83 (±0.41) 0.47 (±0.44) 222 0.00 0.00 −0.08 (±0.6) 0.72 (±0.36) 0.34 (±0.34) 0.03 (±0.43) −0.21 (±0.47) 223 0.00 0.00 −0.13 (±0.48) 0.7 (±0.42) 0.43 (±0.35) 0.21 (±0.37) 0.04 (±0.47) 224 0.00 0.00 0.84 (±0.42) 1.99 (±0.5) 1.3 (±0.36) 1.12 (±0.54) 1 (±0.41) 225 0.00 0.00 −1.17 (±0.42) 0.48 (±0.56) −0.59 (±0.47) −0.51 (±0.48) −0.67 (±0.46) 226 0.00 0.00 0.32 (±0.36) 1.3 (±0.44) 0.8 (±0.47) 0.72 (±0.36) 0.48 (±0.36) 227 0.00 0.00 −0.06 (±0.37) 0.89 (±0.47) 0.41 (±0.26) 0.22 (±0.38) 0.18 (±0.38) 228 0.00 0.00 −0.97 (±0.47) 0.3 (±0.36) −0.29 (±0.34) −0.56 (±0.44) −0.79 (±0.41) 229 0.00 0.00 −1.04 (±0.41) 0.18 (±0.42) −0.4 (±0.29) −0.83 (±0.4) −0.98 (±0.44) 230 0.00 0.00 −1.25 (±0.44) −0.03 (±0.44) −0.64 (±0.34) −0.78 (±0.33) −1.06 (±0.38) 231 0.00 0.00 −0.89 (±0.39) 0.38 (±0.45) −0.27 (±0.38) −0.53 (±0.34) −0.77 (±0.42) 232 0.00 0.00 0.07 (±0.43) 0.89 (±0.41) 0.57 (±0.35) 0.39 (±0.27) 0.18 (±0.36) 233 0.00 0.00 −0.12 (±0.42) 0.62 (±0.34) 0.35 (±0.38) 0.05 (±0.33) 0.01 (±0.43) 234 0.00 0.00 0.07 (±0.5) 0.91 (±0.35) 0.55 (±0.38) 0.32 (±0.31) 0.07 (±0.38) 235 0.00 0.00 0.05 (±0.52) 0.65 (±0.51) 0.42 (±0.36) 0.18 (±0.33) 0.01 (±0.41) 236 0.00 0.01 0.12 (±0.59) 0.69 (±0.48) 0.23 (±0.47) 0.29 (±0.31) −0.05 (±0.38) 237 0.00 0.00 0.34 (±0.6) 1.35 (±0.59) 0.62 (±0.44) 0.53 (±0.43) 0.18 (±0.52) 238 0.00 0.00 −0.52 (±0.39) −0.02 (±0.36) −0.3 (±0.38) −0.25 (±0.28) −0.54 (±0.35) 239 0.00 0.00 −0.26 (±0.44) 0.49 (±0.5) 0.15 (±0.49) 0.01 (±0.31) −0.23 (±0.27) 240 0.00 0.00 0.1 (±0.48) 1.16 (±0.4) 0.82 (±0.48) 0.87 (±0.44) 0.19 (±0.47) 241 0.00 0.00 0.24 (±0.45) 1.23 (±0.38) 0.92 (±0.45) 0.91 (±0.45) 0.24 (±0.49) 242 0.00 0.00 −0.73 (±0.35) −0.24 (±0.37) −0.46 (±0.38) −0.45 (±0.37) −0.69 (±0.37) 243 0.00 0.00 0.37 (±0.42) 0.79 (±0.31) 0.58 (±0.31) 0.61 (±0.35) 0.33 (±0.39) 244 0.00 0.00 0.21 (±0.46) 0.6 (±0.34) 0.44 (±0.45) 0.47 (±0.52) 0.11 (±0.5) 245 0.01 0.04 0.7 (±0.52) 1.13 (±0.34) 0.96 (±0.4) 0.83 (±0.48) 0.76 (±0.43) 246 0.00 0.01 0.67 (±0.5) 1.18 (±0.38) 1.08 (±0.39) 0.92 (±0.33) 0.8 (±0.4) 247 0.00 0.01 −0.62 (±0.43) −0.41 (±0.44) −0.3 (±0.41) −0.24 (±0.33) −0.45 (±0.36) 248 0.00 0.00 −0.81 (±0.46) −0.41 (±0.45) −0.47 (±0.44) −0.37 (±0.31) −0.75 (±0.48) 249 0.00 0.00 0.62 (±0.5) 1.44 (±0.42) 1.29 (±0.36) 1.21 (±0.46) 0.99 (±0.42) 250 0.00 0.01 −0.11 (±0.44) 0.43 (±0.41) 0.2 (±0.42) 0.3 (±0.37) 0.09 (±0.37) 251 0.00 0.01 −0.68 (±0.47) −0.07 (±0.39) −0.28 (±0.39) −0.31 (±0.34) −0.44 (±0.33) 252 0.00 0.00 1.11 (±0.46) 1.71 (±0.51) 1.61 (±0.46) 1.43 (±0.47) 1.3 (±0.43) 253 0.00 0.00 0.43 (±0.45) 0.92 (±0.44) 0.84 (±0.43) 0.67 (±0.36) 0.49 (±0.34) 254 0.00 0.00 0.39 (±0.57) 1.02 (±0.43) 0.93 (±0.47) 0.69 (±0.42) 0.56 (±0.46) 255 0.00 0.00 0.6 (±0.48) 1.02 (±0.37) 0.99 (±0.34) 0.6 (±0.4) 0.64 (±0.32) 256 0.00 0.00 1.88 (±0.52) 2.71 (±0.55) 2.21 (±0.49) 2.08 (±0.61) 2.09 (±0.53) 257 0.00 0.02 1.83 (±0.55) 2.48 (±0.6) 2.19 (±0.45) 2.13 (±0.55) 2.08 (±0.52) 258 0.00 0.00 0.33 (±0.46) 0.98 (±0.44) 0.7 (±0.45) 0.5 (±0.42) 0.37 (±0.46) 259 0.00 0.00 1.72 (±0.46) 2.6 (±0.53) 2.06 (±0.41) 1.94 (±0.48) 1.77 (±0.61) 260 0.00 0.00 0.32 (±0.36) 1 (±0.43) 0.68 (±0.37) 0.57 (±0.42) 0.53 (±0.5) 261 0.00 0.00 0.57 (±0.37) 1.24 (±0.38) 0.9 (±0.41) 0.61 (±0.44) 0.6 (±0.43) 262 0.00 0.00 0.34 (±0.43) 1.08 (±0.4) 0.86 (±0.32) 0.71 (±0.29) 0.6 (±0.4) 263 0.00 0.00 0.28 (±0.58) 0.91 (±0.46) 0.81 (±0.42) 0.67 (±0.33) 0.56 (±0.46) 264 0.00 0.00 −0.52 (±0.39) 0.03 (±0.41) −0.18 (±0.31) −0.21 (±0.28) −0.37 (±0.34) 265 0.00 0.00 −0.34 (±0.36) 0.11 (±0.45) −0.14 (±0.3) −0.18 (±0.36) −0.36 (±0.38) 266 0.00 0.00 0.66 (±0.48) 1.25 (±0.57) 1.03 (±0.52) 1 (±0.51) 0.76 (±0.55) 267 0.00 0.01 0.75 (±0.54) 1.03 (±0.48) 1.06 (±0.6) 0.99 (±0.61) 0.77 (±0.4) 268 0.00 0.00 0.07 (±0.46) 0.44 (±0.47) 0.38 (±0.49) 0.29 (±0.35) −0.08 (±0.48) 269 0.00 0.00 1.36 (±0.35) 1.76 (±0.39) 1.82 (±0.53) 1.6 (±0.51) 1.53 (±0.39) 270 0.01 0.04 3.53 (±0.67) 4.22 (±0.79) 3.93 (±0.81) 3.73 (±0.9) 3.69 (±0.96) 271 0.00 0.00 3.99 (±0.55) 4.5 (±0.51) 4.36 (±0.45) 4.18 (±0.64) 4.13 (±0.52) 272 0.00 0.03 0.69 (±0.64) 1.22 (±0.47) 1.15 (±0.6) 0.94 (±0.52) 0.92 (±0.56) 273 0.00 0.00 1.42 (±0.51) 2.23 (±0.6) 1.86 (±0.58) 1.75 (±0.65) 1.73 (±0.61) 274 0.00 0.00 0.47 (±0.28) 0.85 (±0.33) 0.82 (±0.42) 0.69 (±0.39) 0.65 (±0.34) 275 0.00 0.00 2.53 (±0.78) 3.81 (±0.8) 3.45 (±0.74) 2.86 (±0.9) 2.4 (±0.68) 276 0.00 0.00 1.17 (±0.74) 2.51 (±0.56) 2.14 (±0.62) 1.76 (±0.53) 1.55 (±0.61) 277 0.00 0.00 1.61 (±0.71) 2.31 (±0.66) 2.1 (±0.71) 2.05 (±0.63) 1.68 (±0.69) 278 0.00 0.02 3.22 (±0.49) 3.94 (±0.57) 3.64 (±0.6) 3.53 (±0.62) 3.54 (±0.5) 279 0.00 0.00 1.76 (±0.49) 2.34 (±0.66) 1.99 (±0.53) 1.72 (±0.49) 1.78 (±0.46) 280 0.00 0.00 0.65 (±0.41) 1.4 (±0.46) 1.07 (±0.43) 0.93 (±0.46) 0.68 (±0.4) 281 0.00 0.00 1.24 (±0.39) 2.15 (±0.5) 1.81 (±0.54) 1.54 (±0.56) 1.47 (±0.48) 282 0.00 0.00 1.09 (±0.61) 2.05 (±0.61) 1.63 (±0.62) 1.61 (±0.61) 1.32 (±0.73) 283 0.01 0.04 0.59 (±0.49) 0.93 (±0.43) 0.79 (±0.4) 0.63 (±0.37) 0.5 (±0.46) 284 0.00 0.01 0.74 (±0.63) 1.42 (±0.63) 1.03 (±0.5) 0.85 (±0.53) 0.7 (±0.55) 285 0.00 0.00 0.04 (±0.47) 0.71 (±0.39) 0.28 (±0.5) 0.25 (±0.44) 0.3 (±0.4) 286 0.01 0.04 0.04 (±0.42) 0.48 (±0.32) 0.32 (±0.51) 0.2 (±0.44) 0.11 (±0.38) 287 0.00 0.00 0.37 (±0.62) 0.63 (±0.53) 0.93 (±0.45) 0.48 (±0.52) 0.48 (±0.37) 288 0.00 0.00 −0.73 (±0.35) −0.49 (±0.28) −0.46 (±0.29) −0.49 (±0.27) −0.76 (±0.3) 289 0.00 0.00 −0.12 (±0.43) 0.2 (±0.47) 0.35 (±0.44) 0.13 (±0.31) −0.13 (±0.31) 290 0.00 0.00 −0.12 (±0.72) 0.17 (±0.75) 0.57 (±0.74) 0.13 (±0.68) −0.18 (±0.61) 291 0.00 0.00 0.37 (±0.49) 0.79 (±0.56) 0.95 (±0.58) 0.53 (±0.52) 0.38 (±0.58) 292 0.00 0.00 0.07 (±0.33) 0.43 (±0.38) 0.59 (±0.49) 0.29 (±0.37) 0.14 (±0.28) 293 0.00 0.03 −2.25 (±0.4) −1.87 (±0.41) −2.29 (±0.33) −2.25 (±0.4) −2.26 (±0.32) 294 0.01 0.03 −1.01 (±0.41) −0.5 (±0.36) −0.98 (±0.43) −0.82 (±0.4) −1.12 (±0.4) 295 0.00 0.00 −2.31 (±0.46) −1.8 (±0.29) −2.12 (±0.33) −2.21 (±0.3) −2.45 (±0.34) 296 0.00 0.01 −0.7 (±0.54) −0.27 (±0.43) −0.6 (±0.3) −0.67 (±0.36) −0.95 (±0.47) 297 0.00 0.01 −0.77 (±0.64) −0.2 (±0.47) −0.63 (±0.36) −0.73 (±0.47) −0.83 (±0.49) 298 0.00 0.01 −0.98 (±0.64) −0.36 (±0.41) −0.76 (±0.43) −0.68 (±0.36) −1.01 (±0.44) 299 0.00 0.01 −1.52 (±0.59) −1 (±0.49) −1.42 (±0.54) −1.33 (±0.35) −1.69 (±0.33) 300 0.01 0.04 0.05 (±0.75) 0.43 (±0.56) 0.25 (±0.55) 0.18 (±0.34) −0.13 (±0.48) 301 0.00 0.01 −1.89 (±0.46) −2.02 (±0.31) −2.29 (±0.33) −1.98 (±0.36) −2.32 (±0.39) 302 0.00 0.00 −0.26 (±0.48) −0.12 (±0.39) −0.59 (±0.46) −0.41 (±0.34) −0.7 (±0.41) 303 0.00 0.00 −1.22 (±0.44) −0.96 (±0.4) −1.24 (±0.38) −1.01 (±0.35) −1.47 (±0.43) 304 0.00 0.00 −0.97 (±0.43) −0.97 (±0.26) −1.16 (±0.4) −1 (±0.21) −1.33 (±0.43) 305 0.01 0.04 −0.33 (±0.46) 0.04 (±0.44) −0.45 (±0.37) −0.48 (±0.47) −0.84 (±0.51) 306 0.01 0.05 −0.16 (±0.31) 0 (±0.25) −0.27 (±0.33) −0.16 (±0.26) −0.33 (±0.35) 307 0.00 0.03 0.91 (±0.64) 1.03 (±0.45) 0.99 (±0.49) 1.04 (±0.4) 0.6 (±0.51) 308 0.01 0.04 −0.05 (±0.29) −0.05 (±0.3) −0.29 (±0.35) −0.09 (±0.23) −0.23 (±0.37) 309 0.01 0.04 −2.34 (±0.22) −2.22 (±0.27) −2.42 (±0.38) −2.26 (±0.43) −2.47 (±0.29) 310 0.01 0.05 0.27 (±0.38) 0.64 (±0.41) 0.55 (±0.34) 0.4 (±0.41) 0.31 (±0.41) 311 0.00 0.02 −0.49 (±0.31) −0.38 (±0.28) −0.48 (±0.28) −0.31 (±0.18) −0.58 (±0.27) 312 0.00 0.02 −0.67 (±0.27) −0.58 (±0.23) −0.77 (±0.22) −0.75 (±0.22) −0.84 (±0.21) 313 0.00 0.03 −0.34 (±0.33) −0.15 (±0.24) −0.25 (±0.26) −0.28 (±0.24) −0.44 (±0.28) 314 0.01 0.04 −0.46 (±0.25) −0.45 (±0.17) −0.6 (±0.23) −0.54 (±0.21) −0.64 (±0.26) 315 0.00 0.02 −0.34 (±0.3) −0.32 (±0.18) −0.44 (±0.25) −0.4 (±0.23) −0.59 (±0.31) 316 0.01 0.03 −0.62 (±0.28) −0.51 (±0.21) −0.66 (±0.26) −0.7 (±0.21) −0.77 (±0.27) 317 0.01 0.05 −0.53 (±0.31) −0.61 (±0.27) −0.6 (±0.32) −0.7 (±0.25) −0.77 (±0.33) 318 0.01 0.04 −0.79 (±0.28) −0.82 (±0.17) −0.89 (±0.21) −0.83 (±0.26) −1.02 (±0.28) 319 0.00 0.00 −0.81 (±0.29) −0.73 (±0.31) −0.95 (±0.3) −0.95 (±0.28) −1.1 (±0.36) 320 0.01 0.04 −0.46 (±0.34) −0.41 (±0.23) −0.54 (±0.27) −0.61 (±0.27) −0.67 (±0.41) 321 0.00 0.01 −0.59 (±0.31) −0.51 (±0.22) −0.68 (±0.23) −0.72 (±0.3) −0.84 (±0.36) 322 0.00 0.02 −0.48 (±0.46) −0.44 (±0.25) −0.65 (±0.32) −0.72 (±0.3) −0.76 (±0.41) 323 0.01 0.04 −0.58 (±0.3) −0.5 (±0.27) −0.66 (±0.28) −0.66 (±0.27) −0.76 (±0.29) 324 0.01 0.04 −0.53 (±0.34) −0.37 (±0.26) −0.56 (±0.36) −0.61 (±0.25) −0.7 (±0.3) 325 0.00 0.01 −0.3 (±0.31) −0.15 (±0.3) −0.4 (±0.26) −0.41 (±0.26) −0.53 (±0.31) 326 0.00 0.01 −0.33 (±0.24) −0.25 (±0.23) −0.5 (±0.31) −0.36 (±0.26) −0.48 (±0.32) 327 0.00 0.01 −0.41 (±0.25) −0.33 (±0.2) −0.5 (±0.29) −0.45 (±0.2) −0.63 (±0.28) 328 0.00 0.00 −0.75 (±0.28) −0.56 (±0.16) −0.86 (±0.26) −0.85 (±0.23) −0.99 (±0.29) 329 0.01 0.03 −0.56 (±0.21) −0.45 (±0.16) −0.65 (±0.22) −0.65 (±0.27) −0.7 (±0.32) 330 0.00 0.01 −0.3 (±0.27) 0.08 (±0.26) −0.21 (±0.25) −0.3 (±0.24) −0.37 (±0.28) 331 0.00 0.00 −0.45 (±0.33) −0.14 (±0.3) −0.38 (±0.28) −0.47 (±0.24) −0.48 (±0.28) 332 0.01 0.04 −0.54 (±0.41) −0.06 (±0.47) −0.47 (±0.29) −0.4 (±0.36) −0.42 (±0.41) 333 0.00 0.00 −0.63 (±0.25) −0.27 (±0.25) −0.41 (±0.23) −0.48 (±0.28) −0.57 (±0.24) 334 0.00 0.02 0.15 (±0.38) 0.43 (±0.27) 0.34 (±0.31) 0.13 (±0.23) 0.3 (±0.25) 335 0.01 0.05 0.27 (±0.27) 0.45 (±0.25) 0.32 (±0.19) 0.25 (±0.2) 0.24 (±0.18) 336 0.00 0.02 −0.11 (±0.37) 0.1 (±0.29) 0 (±0.17) −0.16 (±0.19) −0.17 (±0.28) 337 0.01 0.05 0.07 (±0.3) 0.15 (±0.33) 0.12 (±0.2) −0.05 (±0.29) −0.07 (±0.26) 338 0.00 0.02 −0.25 (±0.48) −0.09 (±0.39) −0.27 (±0.29) −0.35 (±0.27) −0.47 (±0.3) 339 0.00 0.01 −0.5 (±0.35) −0.29 (±0.35) −0.53 (±0.31) −0.62 (±0.35) −0.65 (±0.27) 340 0.00 0.00 −0.06 (±0.2) 0.1 (±0.2) −0.08 (±0.2) −0.15 (±0.21) −0.09 (±0.2) 341 0.01 0.04 −0.22 (±0.13) −0.03 (±0.21) −0.11 (±0.27) −0.23 (±0.21) −0.21 (±0.18) 342 0.00 0.01 0.17 (±0.41) 0.53 (±0.31) 0.4 (±0.43) 0.15 (±0.46) 0.09 (±0.41) 343 0.00 0.02 −0.36 (±0.16) −0.23 (±0.17) −0.34 (±0.15) −0.41 (±0.23) −0.47 (±0.23) 344 0.00 0.02 0.36 (±0.41) 0.73 (±0.21) 0.48 (±0.53) 0.15 (±0.46) 0.42 (±0.63) 345 0.00 0.00 0.12 (±0.24) 0.38 (±0.21) 0.15 (±0.24) 0.23 (±0.23) 0.08 (±0.24) 346 0.00 0.00 −0.65 (±0.38) −0.02 (±0.42) −0.48 (±0.4) −0.28 (±0.45) −0.42 (±0.52) 347 0.00 0.03 −0.66 (±0.32) −0.34 (±0.21) −0.54 (±0.2) −0.6 (±0.26) −0.49 (±0.28) 348 0.00 0.03 −0.48 (±0.42) −0.14 (±0.35) −0.31 (±0.32) −0.38 (±0.36) −0.44 (±0.39) 349 0.00 0.01 −0.23 (±0.24) 0.01 (±0.24) −0.04 (±0.26) −0.21 (±0.24) −0.19 (±0.27) 350 0.00 0.02 −0.07 (±0.22) 0.17 (±0.33) −0.04 (±0.23) −0.24 (±0.26) −0.13 (±0.24) 351 0.00 0.02 −0.96 (±0.26) −0.82 (±0.26) −0.99 (±0.24) −1.08 (±0.28) −1.04 (±0.23) 352 0.01 0.05 0.06 (±0.31) 0.18 (±0.33) 0.08 (±0.3) −0.12 (±0.29) 0 (±0.25) 353 0.01 0.04 −0.07 (±0.26) 0.19 (±0.35) 0 (±0.26) −0.06 (±0.28) −0.02 (±0.25)

TABLE 8 Cluster 3 Sequence PC-Test Median (±Standard deviation) No. p-value q-value t0 t0 post t3 post t7 post t14 post 354 0.01 0.05 −0.37 (±0.3) −0.32 (±0.26) −0.49 (±0.2) −0.54 (±0.27) −0.48 (±0.25) 355 0.01 0.04 −0.24 (±0.29) −0.07 (±0.26) −0.18 (±0.23) −0.33 (±0.33) −0.27 (±0.25) 356 0.00 0.01 0.18 (±0.32) 0.3 (±0.5) 0 (±0.27) 0 (±0.28) −0.04 (±0.34) 357 0.00 0.01 −0.39 (±0.32) −0.47 (±0.31) −0.58 (±0.32) −0.44 (±0.3) −0.7 (±0.29) 358 0.00 0.02 −0.16 (±0.44) −0.08 (±0.41) −0.41 (±0.46) −0.44 (±0.42) −0.42 (±0.38) 359 0.01 0.04 −0.37 (±0.43) −0.26 (±0.44) −0.51 (±0.35) −0.55 (±0.31) −0.61 (±0.35) 360 0.00 0.01 0.05 (±0.29) −0.31 (±0.22) −0.27 (±0.21) −0.22 (±0.39) −0.33 (±0.46) 361 0.00 0.03 −0.45 (±0.27) −0.4 (±0.43) −0.42 (±0.4) −0.15 (±0.42) −0.58 (±0.38) 362 0.01 0.04 −0.4 (±0.32) −0.41 (±0.38) −0.73 (±0.5) −0.43 (±0.28) −0.57 (±0.34) 363 0.00 0.01 −0.47 (±0.35) −0.55 (±0.36) −0.76 (±0.35) −0.29 (±0.4) −0.68 (±0.5) 364 0.00 0.03 −0.13 (±0.23) −0.04 (±0.24) −0.14 (±0.27) 0.06 (±0.27) −0.23 (±0.35) 365 0.01 0.05 0.01 (±0.26) 0.34 (±0.47) −0.06 (±0.5) 0.12 (±0.4) −0.08 (±0.5) 366 0.01 0.03 0.04 (±0.34) 0.2 (±0.64) −0.04 (±0.43) −0.28 (±0.43) −0.12 (±0.33) 367 0.00 0.02 −0.33 (±0.25) −0.61 (±0.27) −0.51 (±0.24) −0.41 (±0.43) −0.38 (±0.3) 368 0.00 0.01 0.25 (±0.4) 0.32 (±0.3) 0.07 (±0.22) 0.1 (±0.36) 0.35 (±0.21) 369 0.01 0.05 −0.09 (±0.33) 0.39 (±0.38) 0.08 (±0.43) 0.14 (±0.51) 0.2 (±0.51) 370 0.00 0.00 −0.88 (±0.38) −0.49 (±0.3) −0.78 (±0.3) −0.62 (±0.3) −0.84 (±0.3) 371 0.00 0.01 −0.33 (±0.35) −0.05 (±0.55) −0.56 (±0.51) −0.32 (±0.42) −0.51 (±0.55) 372 0.00 0.00 −0.03 (±0.42) 0.31 (±0.32) 0.09 (±0.36) −0.1 (±0.44) −0.14 (±0.3) 373 0.01 0.05 −0.09 (±0.31) −0.03 (±0.35) −0.13 (±0.35) −0.27 (±0.37) −0.23 (±0.35) 374 0.01 0.04 0.21 (±0.4) 0.24 (±0.45) 0.09 (±0.52) −0.06 (±0.47) 0.19 (±0.37) 375 0.00 0.03 −0.25 (±0.34) −0.14 (±0.22) −0.22 (±0.24) −0.42 (±0.38) −0.42 (±0.28) 376 0.00 0.00 −0.02 (±0.28) −0.07 (±0.2) −0.24 (±0.19) −0.23 (±0.22) −0.28 (±0.21) 377 0.01 0.04 −1.01 (±0.37) −0.82 (±0.29) −1.11 (±0.29) −1 (±0.4) −1.22 (±0.28) 378 0.00 0.01 −0.67 (±0.27) −0.63 (±0.22) −0.86 (±0.19) −0.79 (±0.24) −0.87 (±0.28) 379 0.01 0.04 −0.83 (±0.27) −0.83 (±0.23) −0.93 (±0.3) −1 (±0.32) −1 (±0.25) 380 0.01 0.04 −0.22 (±0.37) −0.51 (±0.28) −0.42 (±0.38) −0.54 (±0.28) −0.54 (±0.3) 381 0.00 0.01 −1.2 (±0.24) −1.04 (±0.24) −1.2 (±0.25) −1.29 (±0.24) −1.3 (±0.28) 382 0.00 0.02 −0.81 (±0.29) −0.66 (±0.27) −0.97 (±0.24) −0.94 (±0.32) −0.98 (±0.34) 383 0.01 0.05 −0.46 (±0.24) −0.34 (±0.26) −0.56 (±0.31) −0.55 (±0.33) −0.46 (±0.21) 384 0.00 0.02 −0.04 (±0.4) −0.01 (±0.2) −0.16 (±0.27) −0.33 (±0.41) −0.26 (±0.35) 385 0.00 0.01 −0.49 (±0.46) −0.44 (±0.5) −0.59 (±0.55) −0.9 (±0.55) −1.04 (±0.56) 386 0.00 0.03 −0.76 (±0.21) −0.72 (±0.18) −0.93 (±0.23) −0.88 (±0.25) −0.91 (±0.27) 387 0.01 0.04 −1.01 (±0.57) −0.65 (±0.46) −0.59 (±0.39) −0.73 (±0.53) −1.01 (±0.68) 388 0.01 0.04 −1.58 (±0.41) −1.37 (±0.26) −1.5 (±0.46) −1.39 (±0.44) −1.8 (±0.36) 389 0.00 0.02 −0.15 (±0.33) −0.03 (±0.36) −0.27 (±0.38) −0.24 (±0.39) −0.42 (±0.33) 390 0.00 0.00 −0.82 (±0.47) −0.8 (±0.42) −1.1 (±0.41) −1.09 (±0.44) −1.36 (±0.42) 391 0.01 0.04 −0.6 (±0.5) −0.49 (±0.29) −0.81 (±0.54) −0.73 (±0.44) −0.98 (±0.41) 392 0.00 0.00 −0.83 (±0.26) −1.08 (±0.43) −1.23 (±0.38) −0.92 (±0.3) −1.2 (±0.26) 393 0.01 0.04 −0.17 (±0.36) −0.06 (±0.26) −0.14 (±0.27) −0.02 (±0.28) −0.31 (±0.35) 394 0.00 0.00 −0.72 (±0.34) −0.73 (±0.43) −1.09 (±0.47) −0.81 (±0.41) −1.15 (±0.5) 395 0.01 0.04 −0.25 (±0.33) −0.51 (±0.47) −0.49 (±0.57) −0.36 (±0.47) −0.78 (±0.46) 396 0.00 0.02 −0.51 (±0.2) −0.3 (±0.33) −0.49 (±0.25) −0.49 (±0.27) −0.6 (±0.3) 397 0.00 0.01 −1.16 (±0.33) −1.22 (±0.49) −1.34 (±0.5) −1.61 (±0.6) −1.62 (±0.45) 398 0.00 0.01 −0.19 (±0.33) −0.11 (±0.33) −0.31 (±0.28) −0.35 (±0.41) −0.46 (±0.35) 399 0.01 0.03 −1.63 (±0.25) −1.77 (±0.37) −1.84 (±0.36) −1.81 (±0.42) −1.94 (±0.31) 400 0.00 0.01 −0.35 (±0.41) −0.52 (±0.42) −0.94 (±0.58) −0.76 (±0.46) −0.81 (±0.44) 401 0.00 0.02 −0.54 (±0.65) −0.56 (±0.61) −0.94 (±0.55) −0.72 (±0.73) −1 (±0.53) 402 0.01 0.05 −0.55 (±0.24) −0.45 (±0.28) −0.64 (±0.31) −0.49 (±0.21) −0.61 (±0.24) 403 0.00 0.00 −0.32 (±0.44) −0.73 (±0.34) −0.5 (±0.3) −0.69 (±0.31) −0.71 (±0.36) 404 0.01 0.04 −0.23 (±0.38) −0.65 (±0.34) −0.53 (±0.41) −0.66 (±0.53) −0.62 (±0.37) 405 0.01 0.05 0.12 (±0.42) 0.04 (±0.41) −0.07 (±0.38) −0.18 (±0.41) −0.11 (±0.3) 406 0.01 0.05 −0.76 (±0.36) −0.81 (±0.4) −1 (±0.34) −0.98 (±0.45) −0.99 (±0.4) 407 0.01 0.04 −0.69 (±0.58) −0.93 (±0.52) −1.18 (±0.61) −0.8 (±0.72) −1.22 (±0.65) 408 0.01 0.05 −0.78 (±0.22) −0.62 (±0.26) −0.77 (±0.34) −0.83 (±0.28) −0.87 (±0.24) 409 0.01 0.04 −0.33 (±0.37) −0.1 (±0.37) −0.41 (±0.42) −0.38 (±0.34) −0.31 (±0.34) 410 0.00 0.00 −0.06 (±0.44) 0.09 (±0.17) −0.22 (±0.49) −0.34 (±0.36) 0.05 (±0.38)

TABLE 9 Cluster 4 Sequence PC-Test Median (±Standard deviation) No. p-value q-value t0 t0 post t3 post t7 post t14 post 411 0.00 0.02 0.27 (±0.33) −0.04 (±0.44) −0.16 (±0.46) 0.02 (±0.49) 0.24 (±0.44) 412 0.01 0.05 −0.3 (±0.33) −0.43 (±0.42) 0.01 (±0.5) −0.14 (±0.48) −0.13 (±0.38) 413 0.00 0.03 −0.35 (±0.41) −0.66 (±0.44) −0.47 (±0.44) −0.24 (±0.32) −0.22 (±0.43) 414 0.01 0.05 −0.08 (±0.43) −0.32 (±0.41) −0.4 (±0.42) −0.22 (±0.31) −0.08 (±0.37) 415 0.01 0.03 0.01 (±0.26) −0.16 (±0.29) −0.34 (±0.34) −0.13 (±0.22) −0.18 (±0.28) 416 0.01 0.05 0 (±0.31) −0.01 (±0.56) −0.19 (±0.4) 0.14 (±0.36) −0.16 (±0.45) 417 0.00 0.02 0.57 (±0.61) 0.17 (±0.46) 0.19 (±0.47) 0.53 (±0.46) 0.23 (±0.49) 418 0.00 0.01 −0.19 (±0.5) −0.4 (±0.41) −0.57 (±0.48) −0.19 (±0.34) −0.56 (±0.54) 419 0.00 0.02 −0.31 (±0.43) −0.69 (±0.5) −0.8 (±0.51) −0.41 (±0.4) −0.51 (±0.43) 420 0.01 0.05 0.35 (±0.46) 0.25 (±0.44) −0.05 (±0.58) 0.28 (±0.45) −0.04 (±0.36) 421 0.00 0.01 −0.08 (±0.43) −0.39 (±0.34) −0.56 (±0.54) −0.07 (±0.52) −0.37 (±0.4) 422 0.01 0.04 −0.17 (±0.39) −0.48 (±0.37) −0.4 (±0.37) −0.33 (±0.31) −0.48 (±0.28) 423 0.00 0.00 0.35 (±0.4) −0.35 (±0.39) −0.23 (±0.43) 0.22 (±0.48) −0.15 (±0.63) 424 0.00 0.03 −0.35 (±0.22) −0.56 (±0.24) −0.44 (±0.2) −0.36 (±0.2) −0.36 (±0.23) 425 0.01 0.04 −0.41 (±0.35) −0.73 (±0.25) −0.72 (±0.26) −0.7 (±0.31) −0.68 (±0.35) 426 0.01 0.03 −0.02 (±0.35) −0.34 (±0.34) −0.27 (±0.39) −0.16 (±0.33) −0.26 (±0.37) 427 0.01 0.05 −0.45 (±0.33) −0.74 (±0.3) −0.78 (±0.36) −0.58 (±0.4) −0.58 (±0.37) 428 0.00 0.01 0.33 (±0.39) −0.23 (±0.37) 0.14 (±0.43) 0.24 (±0.46) 0.01 (±0.49) 429 0.01 0.05 −0.4 (±0.41) −0.59 (±0.38) −0.82 (±0.56) −0.76 (±0.58) −0.77 (±0.41) 430 0.00 0.01 −0.27 (±0.3) −0.39 (±0.27) −0.54 (±0.25) −0.49 (±0.3) −0.58 (±0.29) 431 0.01 0.04 −1.4 (±0.36) −1.72 (±0.26) −1.75 (±0.34) −1.6 (±0.35) −1.7 (±0.4) 432 0.00 0.00 −0.76 (±0.28) −1.04 (±0.21) −1.07 (±0.24) −0.91 (±0.31) −1.06 (±0.2) 433 0.00 0.00 −0.91 (±0.36) −1.26 (±0.34) −1.41 (±0.25) −1.3 (±0.42) −1.32 (±0.35) 434 0.01 0.04 −1.88 (±0.27) −2.04 (±0.21) −2.08 (±0.19) −2 (±0.26) −2.08 (±0.18) 435 0.00 0.01 −0.61 (±0.53) −0.73 (±0.38) −1.06 (±0.45) −0.96 (±0.55) −1.07 (±0.45) 436 0.01 0.05 −0.54 (±0.27) −0.56 (±0.23) −0.79 (±0.3) −0.75 (±0.35) −0.77 (±0.31) 437 0.00 0.02 −2.12 (±0.38) −2.32 (±0.78) −2.43 (±0.43) −2.15 (±0.51) −2.45 (±0.3) 438 0.00 0.00 −2.01 (±0.36) −2.53 (±0.5) −2.34 (±0.34) −2.07 (±0.36) −2.36 (±0.36) 439 0.00 0.01 −2.75 (±0.27) −3.13 (±0.4) −3.22 (±0.36) −3.01 (±0.51) −3.23 (±0.3) 440 0.00 0.02 −1.56 (±0.4) −1.95 (±0.38) −1.94 (±0.41) −1.65 (±0.42) −1.83 (±0.52) 441 0.00 0.00 −1.45 (±0.35) −1.92 (±0.3) −1.95 (±0.42) −1.52 (±0.45) −1.69 (±0.35) 442 0.00 0.01 −0.92 (±0.43) −1.24 (±0.29) −1.23 (±0.33) −0.97 (±0.46) −1.16 (±0.39) 443 0.00 0.03 −1.17 (±0.35) −1.37 (±0.26) −1.46 (±0.32) −1.21 (±0.33) −1.42 (±0.34) 444 0.01 0.04 −2 (±0.45) −2.28 (±0.35) −2.05 (±0.46) −2.03 (±0.47) −2.33 (±0.38) 445 0.00 0.02 −1.55 (±0.52) −1.94 (±0.34) −1.9 (±0.41) −1.7 (±0.46) −1.92 (±0.45) 446 0.00 0.01 −0.91 (±0.25) −1.2 (±0.17) −1.27 (±0.27) −1.13 (±0.26) −1.14 (±0.24) 447 0.00 0.00 −0.32 (±0.35) −0.73 (±0.25) −0.62 (±0.38) −0.39 (±0.27) −0.41 (±0.36) 448 0.00 0.00 1.57 (±0.41) 0.9 (±0.41) 1.01 (±0.49) 1.31 (±0.36) 1.42 (±0.47) 449 0.00 0.00 −0.68 (±0.35) −1.22 (±0.36) −1.04 (±0.41) −0.84 (±0.32) −0.89 (±0.4) 450 0.01 0.05 0.54 (±0.39) 0.28 (±0.31) 0.36 (±0.5) 0.49 (±0.48) 0.53 (±0.52) 451 0.00 0.00 −1.38 (±0.42) −1.92 (±0.33) −1.59 (±0.51) −1.19 (±0.48) −1.42 (±0.51) 452 0.00 0.00 0.14 (±0.35) −0.12 (±0.26) −0.05 (±0.31) 0.17 (±0.27) 0.12 (±0.31) 453 0.00 0.00 0.2 (±0.48) −0.13 (±0.42) −0.21 (±0.46) 0.31 (±0.52) 0.14 (±0.5) 454 0.00 0.01 −0.55 (±0.33) −0.83 (±0.48) −0.76 (±0.47) −0.31 (±0.5) −0.52 (±0.47) 455 0.00 0.00 0.03 (±0.42) −0.28 (±0.4) −0.36 (±0.4) 0.06 (±0.61) −0.18 (±0.44) 456 0.00 0.02 −0.4 (±0.4) −0.85 (±0.38) −0.72 (±0.39) −0.6 (±0.36) −0.69 (±0.48) 457 0.00 0.00 −0.01 (±0.32) −0.39 (±0.31) −0.35 (±0.36) −0.19 (±0.31) −0.4 (±0.38) 458 0.01 0.04 −0.16 (±0.31) −0.31 (±0.23) −0.19 (±0.27) −0.05 (±0.26) −0.25 (±0.29) 459 0.00 0.01 −0.49 (±0.46) −0.86 (±0.27) −0.81 (±0.51) −0.65 (±0.48) −0.93 (±0.33) 460 0.01 0.03 −1.43 (±0.39) −1.62 (±0.21) −1.52 (±0.29) −1.37 (±0.26) −1.49 (±0.37) 461 0.01 0.05 −0.46 (±0.4) −0.52 (±0.34) −0.59 (±0.34) −0.4 (±0.28) −0.63 (±0.3) 462 0.01 0.05 −0.02 (±0.4) −0.48 (±0.31) −0.36 (±0.31) −0.4 (±0.32) −0.39 (±0.39) 463 0.00 0.02 0.45 (±0.38) −0.04 (±0.3) 0.3 (±0.41) 0.16 (±0.39) 0.18 (±0.37) 464 0.00 0.01 0.24 (±0.34) −0.07 (±0.23) 0.09 (±0.33) 0.22 (±0.2) −0.04 (±0.28) 465 0.00 0.01 0.3 (±0.4) −0.02 (±0.22) 0.02 (±0.26) 0.13 (±0.25) 0.01 (±0.31) 466 0.00 0.00 0 (±0.42) −0.31 (±0.27) −0.24 (±0.4) 0.02 (±0.42) −0.35 (±0.4) 467 0.00 0.01 −0.23 (±0.4) −0.6 (±0.36) −0.61 (±0.29) −0.43 (±0.36) −0.61 (±0.34) 468 0.00 0.00 1.16 (±0.53) 0.53 (±0.4) 0.7 (±0.28) 0.92 (±0.48) 0.77 (±0.43) 469 0.00 0.02 0 (±0.67) −0.43 (±0.69) −0.42 (±0.74) 0.39 (±0.8) −0.32 (±0.65) 470 0.00 0.00 2.13 (±0.91) 1.46 (±1) 1.46 (±1.14) 2.57 (±1.08) 1.41 (±0.95) 471 0.00 0.00 0.96 (±0.58) −0.01 (±0.64) 0.06 (±0.4) 0.09 (±0.45) 0.29 (±0.45) 472 0.00 0.00 1.48 (±1.05) 0.52 (±0.46) 0.76 (±0.51) 0.94 (±0.7) 1.32 (±0.64) 473 0.00 0.00 0.57 (±0.66) −0.51 (±0.52) −0.5 (±0.56) 0.3 (±0.67) 0.36 (±0.56) 474 0.00 0.00 1.09 (±0.63) 0.06 (±0.43) 0.07 (±0.75) 0.6 (±0.6) 0.53 (±0.69) 475 0.00 0.00 1.64 (±0.76) 0.38 (±0.34) 0.68 (±0.64) 1.14 (±0.65) 1.13 (±0.62) 476 0.00 0.01 1.1 (±0.77) 0.03 (±0.62) 0.13 (±0.53) 0.44 (±0.51) 0.43 (±0.64) 477 0.00 0.00 1.94 (±0.66) 0.74 (±0.57) 0.81 (±0.74) 1.1 (±0.75) 1.18 (±0.68) 478 0.00 0.00 1.62 (±0.69) 0.53 (±0.53) 0.68 (±0.69) 0.97 (±0.74) 1.04 (±0.56) 479 0.00 0.01 −1.67 (±0.56) −2.13 (±0.36) −1.94 (±0.28) −1.69 (±0.36) −1.9 (±0.37) 480 0.00 0.01 −2.4 (±0.25) −2.6 (±0.34) −2.47 (±0.35) −2.22 (±0.37) −2.67 (±0.32) 481 0.01 0.05 −2.16 (±0.34) −2.35 (±0.3) −2.25 (±0.32) −2.01 (±0.28) −2.19 (±0.26) 482 0.00 0.00 −1.39 (±0.33) −1.95 (±0.3) −1.75 (±0.29) −1.6 (±0.3) −1.71 (±0.34) 483 0.00 0.01 −0.7 (±0.62) −1.28 (±0.47) −1.15 (±0.59) −0.74 (±0.35) −0.96 (±0.5) 484 0.00 0.00 −0.76 (±0.34) −1.13 (±0.26) −1.1 (±0.19) −0.85 (±0.17) −1.02 (±0.25) 485 0.00 0.00 −0.35 (±0.24) −0.66 (±0.29) −0.56 (±0.18) −0.4 (±0.22) −0.6 (±0.26) 486 0.00 0.00 −0.31 (±0.29) −0.62 (±0.23) −0.57 (±0.24) −0.31 (±0.27) −0.33 (±0.27) 487 0.00 0.00 −1.16 (±0.44) −1.46 (±0.3) −1.47 (±0.33) −1.16 (±0.28) −1.38 (±0.38) 488 0.00 0.00 −1.51 (±0.53) −1.93 (±0.26) −1.83 (±0.34) −1.55 (±0.36) −1.77 (±0.4) 489 0.00 0.02 −0.81 (±0.27) −0.97 (±0.14) −0.97 (±0.22) −0.85 (±0.18) −0.9 (±0.24) 490 0.00 0.00 1.37 (±0.63) 0.13 (±0.7) 0.47 (±0.66) 0.9 (±0.52) 0.88 (±0.64) 491 0.00 0.00 0.65 (±0.58) −0.03 (±0.56) 0 (±0.4) 0.03 (±0.42) 0.15 (±0.58) 492 0.00 0.02 1.08 (±0.81) 0.11 (±0.51) 0.14 (±0.54) 0.37 (±0.41) 0.35 (±0.59) 493 0.00 0.00 2.94 (±0.51) 1.41 (±0.47) 1.46 (±0.59) 1.85 (±0.69) 1.84 (±0.62) 494 0.00 0.00 −0.42 (±0.62) −1.14 (±0.4) −1.13 (±0.35) −0.73 (±0.36) −0.92 (±0.47) 495 0.00 0.00 −0.47 (±0.48) −1.16 (±0.39) −1.04 (±0.32) −0.86 (±0.38) −0.89 (±0.51) 496 0.00 0.00 −0.54 (±0.44) −1.16 (±0.26) −1.14 (±0.29) −0.93 (±0.43) −0.94 (±0.33) 497 0.00 0.01 −0.47 (±0.36) −0.84 (±0.24) −0.69 (±0.23) −0.53 (±0.24) −0.63 (±0.19) 498 0.00 0.00 −0.12 (±0.57) −0.93 (±0.44) −0.7 (±0.4) −0.35 (±0.4) −0.52 (±0.38) 499 0.00 0.00 −2.33 (±0.43) −2.78 (±0.35) −2.54 (±0.34) −2.25 (±0.35) −2.5 (±0.31) 500 0.00 0.00 −2.16 (±0.41) −2.85 (±0.37) −2.62 (±0.25) −2.33 (±0.33) −2.4 (±0.35) 501 0.00 0.00 −2.04 (±0.44) −2.87 (±0.45) −2.6 (±0.36) −2.35 (±0.33) −2.64 (±0.43) 502 0.00 0.00 −2.25 (±0.46) −3.03 (±0.46) −2.84 (±0.37) −2.47 (±0.34) −2.68 (±0.46) 503 0.00 0.00 −0.06 (±0.48) −0.74 (±0.35) −0.63 (±0.42) −0.48 (±0.33) −0.69 (±0.32) 504 0.00 0.00 0.06 (±0.42) −0.52 (±0.36) −0.41 (±0.46) −0.17 (±0.35) −0.3 (±0.34) 505 0.00 0.00 −1.07 (±0.56) −1.77 (±0.55) −1.59 (±0.47) −1.29 (±0.53) −1.55 (±0.58) 506 0.00 0.00 0.72 (±0.47) 0.1 (±0.38) 0 (±0.35) 0 (±0.38) 0.15 (±0.41) 507 0.01 0.04 −1.34 (±0.5) −1.88 (±0.39) −1.69 (±0.33) −1.54 (±0.38) −1.62 (±0.39) 508 0.00 0.00 −0.42 (±0.39) −0.81 (±0.33) −0.85 (±0.34) −0.61 (±0.33) −0.73 (±0.3) 509 0.01 0.05 0.46 (±0.86) 0.15 (±0.84) 0.32 (±0.86) 0.14 (±0.87) 0.22 (±0.73) 510 0.00 0.00 2.58 (±0.42) 2.12 (±0.59) 2.57 (±0.54) 2.46 (±0.66) 2.27 (±0.51) 511 0.00 0.02 0.77 (±0.47) 0.22 (±0.34) 0.37 (±0.42) 0.59 (±0.49) 0.43 (±0.42) 512 0.00 0.00 −0.2 (±0.38) −0.69 (±0.23) −0.57 (±0.28) −0.33 (±0.26) −0.38 (±0.31) 513 0.00 0.00 0.01 (±0.47) −0.55 (±0.28) −0.51 (±0.36) −0.33 (±0.39) −0.43 (±0.39) 514 0.00 0.00 0.82 (±0.39) −0.09 (±0.26) 0.07 (±0.37) 0.25 (±0.37) 0.22 (±0.4) 515 0.00 0.01 −1.54 (±0.51) −1.79 (±0.32) −1.74 (±0.34) −1.59 (±0.42) −2.01 (±0.34) 516 0.00 0.01 0.27 (±0.55) −0.18 (±0.28) 0.06 (±0.32) 0.17 (±0.41) 0.04 (±0.45) 517 0.00 0.00 −0.79 (±0.41) −1.17 (±0.38) −0.95 (±0.35) −0.77 (±0.37) −0.97 (±0.39) 518 0.00 0.00 0.35 (±0.44) −0.23 (±0.4) 0.31 (±0.37) 0.29 (±0.36) 0.04 (±0.53) 519 0.00 0.00 1.25 (±0.66) 0.54 (±0.56) 1.04 (±0.65) 1.15 (±0.71) 0.71 (±0.61) 520 0.00 0.00 1.71 (±0.91) 0.62 (±0.7) 1.12 (±0.7) 1.21 (±0.82) 1.15 (±0.64) 521 0.00 0.00 0.52 (±0.63) −0.38 (±0.36) −0.08 (±0.41) 0.12 (±0.36) −0.18 (±0.38) 522 0.00 0.00 0.34 (±0.54) −0.28 (±0.34) −0.12 (±0.42) 0.09 (±0.46) −0.1 (±0.43) 523 0.00 0.00 1.55 (±0.76) 0.14 (±0.46) 0.54 (±0.53) 0.79 (±0.67) 0.54 (±0.7) 524 0.01 0.04 1.46 (±0.52) 0.75 (±0.63) 1.24 (±0.57) 1.37 (±0.52) 1.42 (±0.5) 525 0.01 0.04 0.61 (±0.63) 0.04 (±0.41) 0.18 (±0.43) 0.49 (±0.48) 0.36 (±0.5) 526 0.00 0.00 2.53 (±0.77) 1.61 (±0.61) 2.07 (±0.65) 2.31 (±0.91) 2.1 (±0.66) 527 0.00 0.00 3.03 (±0.7) 2.03 (±0.41) 2.47 (±0.46) 2.49 (±0.59) 2.44 (±0.58) 528 0.00 0.00 3.18 (±0.73) 2.27 (±0.57) 2.77 (±0.6) 2.87 (±0.64) 2.65 (±0.61) 529 0.00 0.00 3.12 (±0.72) 2.15 (±0.56) 2.71 (±0.6) 2.86 (±0.7) 2.64 (±0.63) 530 0.01 0.04 1.39 (±0.61) 0.63 (±0.49) 1.04 (±0.47) 1.15 (±0.5) 0.93 (±0.57) 531 0.00 0.00 2.24 (±0.68) 1.32 (±0.44) 1.73 (±0.48) 1.87 (±0.52) 1.66 (±0.5) 532 0.00 0.00 2.3 (±0.69) 1.33 (±0.49) 1.78 (±0.53) 1.95 (±0.56) 1.68 (±0.57)

The inventive determined gene activity and the distribution in specific gene clusters is thus characteristic for operative intervention in a liver transplantation and usable for the in vitro monitoring of liver transplantations.

TABLE 10 GenBank Accession GenBank RefSeq UniGene Accession UniGene UniGene Sequence-ID GenBank clone ID No. Description Accession No. Best RefSeq Description No. Gen Description 1 BC063685.1 Homo sapiens NM_005429.2 Homo sapiens vascular Hs.435215 Vascular VEGFC vascular endothelial endothelial growth factor C endothelial growth factor C, (VEGFC), mRNA growth factor C mRNA (cDNA clone Length = 2076 MGC: 74703 IMAGE: 4513934), complete cds Length = 2076 2 Hs.528087 Inositol ITPKB 1,4,5- trisphosphate 3-kinase B 3 Hs.162868 D4, zinc and DPF3 double PHD fingers, family 3 4 AC011418.5 Homo sapiens NM_002187.2 Homo sapiens interleukin Hs.674 Interleukin IL12B chromosome 5 clone 12B (natural killer cell 12B (natural CTB-9P16, complete stimulatory factor 2, killer cell sequence cytotoxic lymphocyte stimulatory Length = 108511 maturation factor 2, p40) factor 2, (IL12B), mRNA cytotoxic Length = 2347 lymphocyte maturation factor 2, p40) 5 BC014661.1 Homo sapiens NM_022895.1 Homo sapiens hypothetical Hs.528671 Hypothetical FLJ12448 hypothetical protein protein FLJ12448 protein FLJ12448, mRNA (FLJ12448), mRNA FLJ12448 (cDNA clone Length = 1920 MGC: 22955 IMAGE: 4860511), complete cds Length = 1921 6 AY720441.1 Homo sapiens NM_000758.2 Homo sapiens colony Hs.1349 Colony CSF2 granulocyte- stimulating factor 2 stimulating macrophage colony (granulocyte-macrophage) factor 2 stimulating factor 2 (CSF2), mRNA Length = 781 (granulocyte- mRNA, complete cds macrophage) Length = 459 7 BC063474.1 Homo sapiens G NM_018040.1 Homo sapiens G patch Hs.420757 G patch GPATC2 patch domain domain containing 2 domain containing 2, mRNA (GPATC2), mRNA containing 2 (cDNA clone Length = 2338 MGC: 74998 IMAGE: 5206348), complete cds Length = 3250 8 IMAGE: 1707196 9 BC008628.1 Homo sapiens NM_003851.2 Homo sapiens cellular Hs.5710 Cellular CREG1 cellular repressor of repressor of E1A- repressor of E1A-stimulated stimulated genes 1 E1A- genes 1, mRNA (CREG1), mRNA stimulated (cDNA clone Length = 2048 genes 1 MGC: 17147 IMAGE: 4339480), complete cds Length = 1969 10 AY545477.1 Homo sapiens NM_001752.2 Homo sapiens catalase Hs.502302 Catalase CAT catalase (CAT) gene, (CAT), mRNA Length = 2305 complete cds Length = 37116 11 NM_012450 Homo sapiens solute solute carrier SLC13A4 carrier family 13 family 13 (sodium/sulfate (sodium/sulfate symporters), member 4 symporters), (SLC13A4), mRNA member 4 12 Hs.561807 Transcribed locus 13 IMAGE: 2244531 14 AC147090.3 Pan troglodytes BAC Hs.559750 Transcribed clone RP43-58D11 locus from 7, complete sequence Length = 200913 15 Hs.522463 Eukaryotic EEF1A1 translation elongation factor 1 alpha 1 16 IMAGE: 460157 17 AC012360.7 Homo sapiens BAC Hs.446350 Transforming TGFBRAP1 clone RP11-332H14 growth from 2, complete factor, beta sequence receptor Length = 200918 associated Features flanking protein 1 this part of subject sequence: 2755 bp at 5 side: unknown 21585 bp at 3 side: unknown 18 AC002076.2 Homo sapiens BAC clone GS1-345D13 from 7, complete sequence Length = 149764 19 AC011200.9 AC011200 Homo Hs.374023 Potassium KCNQ3 sapiens voltage- chromosome 8 clone gated RP11-71N3, channel, complete sequence KQT-like Length = 161271 subfamily, member 3 20 AC137055.12 Homo sapiens 12 Hs.76253 Ataxin 2 ATXN2 BAC RP11-686G8 (Roswell Park Cancer Institute Human BAC Library) complete sequence Length = 107717 21 BC038295.2 Homo sapiens NM_145185.2 Homo sapiens mitogen- Hs.531754 Mitogen- MAP2K7 mitogen-activated activated protein kinase activated protein kinase kinase kinase 7 (MAP2K7), mRNA protein 7, mRNA (cDNA Length = 3386 kinase clone MGC: 33283 kinase 7 IMAGE: 5269063), complete cds Length = 3446 22 BC017065.1 Homo sapiens tumor NM_032957.2 Homo sapiens regulator of Hs.434878 Tumor TNFRSF6B necrosis factor telomere elongation necrosis receptor superfamily, helicase 1 (RTEL1), factor member 6b, decoy, transcript variant 2, mRNA receptor transcript variant Length = 5288 superfamily, M68E, mRNA (cDNA member 6b, clone MGC: 9587 decoy IMAGE: 3886635), complete cds Length = 1125 23 Hs.163301 CDNA FLJ35132 fis, clone PLACE6008989 24 BC082233.1 Homo sapiens cDNA Hs.187337 Zinc finger LOC148213 clone protein 681 IMAGE: 3833639 Length = 1196 25 BC038289.1 Homo sapiens NM_032964.2 Homo sapiens chemokine Hs.272493 Chemokine CCL15 chemokine (C-C (C-C motif) ligand 15 (C-C motif) motif) ligand 14, (CCL15), transcript variant ligand 15 transcript variant 3, 1, mRNA Length = 1344 mRNA (cDNA clone MGC: 47546 IMAGE: 5222914), complete cds Length = 533 26 AY463360.1 Homo sapiens Hs.476018 Catenin CTNNB1 catenin (cadherin- (cadherin- associated protein), associated beta 1, 88 kDa protein), beta (CTNNB1) gene, 1, 88 kDa complete cds Length = 44505 27 BC001830.2 Homo sapiens NM_015927.3 Homo sapiens transforming Hs.513530 Transforming TGFB1I1 transforming growth growth factor beta 1 growth factor factor beta 1 induced induced transcript 1 beta 1 transcript 1, mRNA (TGFB1I1), mRNA induced (cDNA clone Length = 1824 transcript 1 MGC: 4078 IMAGE: 3030477), complete cds Length = 1824 28 AC004076.1 AC004076 Homo Hs.147471 Similar to sapiens R30217_1 chromosome 19, cosmid R30217, complete sequence Length = 41322 29 BC038289.1 Homo sapiens NM_032964.2 Homo sapiens chemokine Hs.272493 Chemokine CCL15 chemokine (C-C (C-C motif) ligand 15 (C-C motif) motif) ligand 14, (CCL15), transcript variant ligand 15 transcript variant 3, 1, mRNA Length = 1344 mRNA (cDNA clone MGC: 47546 IMAGE: 5222914), complete cds Length = 533 30 Hs.546743 CDNA clone IMAGE: 5272066 31 AC006020.2 AC006020 Homo Hs.119807 Transcribed sapiens PAC clone locus RP5-1049N15 from 7q31.2-7q32, complete sequence Length = 152811 32 AC069387.8 Homo sapiens BAC NM_138938.1 Homo sapiens regenerating Hs.503388 Regenerating PAP clone RP11-295G11 islet-derived 3 alpha islet- from 2, complete (REG3A), transcript variant derived 3 sequence 2, mRNA Length = 1002 alpha Length = 47340 33 Hs.283844 Sideroflexin 3 SFXN3 34 BC023640.1 Homo sapiens, clone XM_520711.1 PREDICTED: Pan Hs.494538 Patched PTCH IMAGE: 4890344, troglodytes similar to homolog mRNA Length = 1429 patched; patched (Drosophila) (Drosophila) homolog (LOC465254), mRNA Length = 5538 35 BC077719.1 Homo sapiens NM_152718.1 Homo sapiens hypothetical Hs.60640 Hypothetical FLJ32009 hypothetical protein protein FLJ32009 protein FLJ32009, mRNA (FLJ32009), mRNA FLJ32009 (cDNA clone Length = 3292 IMAGE: 6305035), complete cds Length = 3385 36 BC073768.1 Homo sapiens heat NM_001540.2 Homo sapiens heat shock Hs.521554 Transcribed shock 27 kDa protein 27 kDa protein 1 (HSPB1), locus, 1, mRNA (cDNA mRNA Length = 865 strongly clone MGC: 88776 similar to IMAGE: 5444848), NP_001531.1 complete cds heat shock Length = 794 27 kDa protein 1; heat shock 27 kD protein 1 [Homo sapiens] 37 Hs.399800 A kinase AKAP8L (PRKA) anchor protein 8-like 38 AC091564.12 Homo sapiens chromosome 11, clone RP11-732A19, complete sequence Length = 211735 39 AC005808.1 AC005808 Homo sapiens chromosome 20, P1 clone 185 (LBNL H136), complete sequence Length = 57434 40 BC015542.1 Homo sapiens NM_006505.2 Homo sapiens poliovirus Hs.171844 Poliovirus PVR poliovirus receptor, receptor (PVR), mRNA receptor mRNA (cDNA clone Length = 3215 MGC: 9603 IMAGE: 3902226), complete cds Length = 3215 41 NM_173582.3 Homo sapiens Hs.26612 Phosphoglucomutase PGM2L1 phosphoglucomutase 2-like 2- 1 (PGM2L1), mRNA like 1 Length = 8519 42 BC023518.2 Homo sapiens heat NM_002157.1 Homo sapiens heat shock Hs.558338 Heat shock HSPE1 shock 10 kDa protein 10 kDa protein 1 10 kDa 1 (chaperonin 10), (chaperonin 10) (HSPE1), protein 1 mRNA (cDNA clone mRNA Length = 538 (chaperonin MGC: 12734 10) IMAGE: 4304224), complete cds Length = 556 43 AC139705.4 Homo sapiens X BAC RP11-102M2 (Roswell Park Cancer Institute Human BAC Library) complete sequence Length = 148316 44 BC040709.2 Homo sapiens cDNA Hs.190394 Hypothetical LOC91661 clone protein IMAGE: 6017695, BC001610 partial cds Length = 608 45 IMAGE: 2179769 46 BC026356.1 Homo sapiens Rho NM_014470.2 Homo sapiens Rho family Hs.124940 Rho family RND1 family GTPase 1, GTPase 1 (RND1), mRNA GTPase 1 mRNA (cDNA clone Length = 1681 MGC: 26932 IMAGE: 4793442), complete cds Length = 1681 47 Hs.523732 Secretoglobin, SCGB1A1 family 1A, member 1 (uteroglobin) 48 Hs.120058 CDNA FLJ34446 fis, clone HLUNG2002050 49 AC026230.5 AC026230 Homo NG_002793.1 Homo sapiens Hs.519304 Pelota PELO sapiens pelota/integrin, alpha 1 homolog chromosome 5 clone region (PELO/ITGA1@) on (Drosophila) CTD-2288O8, chromosome 5 complete sequence Length = 166541 Length = 114802 50 AC026634.11 Homo sapiens Hs.445511 RIO kinase 3 RIOK3 chromosome, clone (yeast) RP11-639E23, complete sequence Length = 164858 51 Hs.177275 Hypothetical DJ122O8.2 protein dJ122O8.2 52 U95367.1 HSU95367 Human NM_014211.1 Homo sapiens gamma- Hs.26225 Gamma- GABRP GABA-A receptor pi aminobutyric acid (GABA) aminobutyric subunit mRNA, A receptor, pi (GABRP), acid (GABA) complete cds mRNA Length = 3282 A receptor, pi Length = 3282 53 IMAGE: 1563026 54 BC009421.1 Homo sapiens NM_153639.1 Homo sapiens Hs.516859 Pantothenate PANK2 pantothenate kinase pantothenate kinase 2 kinase 2 2 (Hallervorden- (Hallervorden-Spatz (Hallervorde Spatz syndrome), syndrome) (PANK2), n-Spatz mRNA (cDNA clone transcript variant 2, mRNA syndrome) IMAGE: 3528235) Length = 1816 Length = 1774 55 BC007433.2 Homo sapiens NM_000366.5 Homo sapiens tropomyosin Hs.133892 Tropomyosin TPM1 tropomyosin 1 1 (alpha) (TPM1), transcript 1 (alpha) (alpha), mRNA variant 5, mRNA (cDNA clone Length = 1294 MGC: 4021 IMAGE: 2962925), complete cds Length = 1256 56 BC028614.1 Homo sapiens Ras NM_017805.2 Homo sapiens Ras Hs.233955 Ras RASIP1 interacting protein 1, interacting protein 1 interacting mRNA (cDNA clone (RASIP1), mRNA protein 1 MGC: 33504 Length = 3311 IMAGE: 4815880), complete cds Length = 3190 57 AY703984.1 Homo sapiens SP-A NM_004740.3 Homo sapiens TGFB1- Hs.462590 TGFB1- TIAF1 receptor subunit SP- induced anti-apoptotic induced anti- R210 alphaS factor 1 (TIAF1), mRNA apoptotic (MYO18A) mRNA, Length = 2110 factor 1 complete cds, alternatively spliced Length = 6479 58 IMAGE: 1882829 59 Hs.444975 Pleiomorphic PLAGL1 adenoma gene-like 1 60 AC009230.3 Homo sapiens BAC Hs.357567 Hypothetical LOC130576 clone RP11-343B21 protein from 2, complete LOC130576 sequence Length = 173993 61 Hs.292580 Hypothetical LOC283551 protein LOC283551 62 BC026340.1 Homo sapiens NM_000674.1 Homo sapiens adenosine Hs.77867 Adenosine ADORA1 adenosine A1 A1 receptor (ADORA1), A1 receptor receptor, mRNA mRNA Length = 2900 (cDNA clone MGC: 26536 IMAGE: 4797116), complete cds Length = 2756 63 AC108080.2 Homo sapiens Hs.268939 Matrin 3 MATR3 chromosome 5 clone CTC-315N8, complete sequence Length = 160494 64 Hs.484678 TBC1 TBC1D7 domain family, member 7 65 AY795482.1 Homo sapiens DnaJ NM_006260.2 Homo sapiens DnaJ Hs.59214 Hypothetical DNAJC3 (Hsp40) homolog, (Hsp40) homolog, protein subfamily C, member subfamily C, member 3 LOC144871 3 (DNAJC3) gene, (DNAJC3), mRNA complete cds Length = 1542 Length = 117695 66 BC042972.1 Homo sapiens NM_001003406.1 Homo sapiens calcium Hs.125116 Calcium CACNA1I calcium channel, channel, voltage- channel, voltage-dependent, dependent, alpha 1I subunit voltage- alpha 1I subunit, (CACNA1I), transcript dependent, mRNA (cDNA clone variant 2, mRNA alpha 1I IMAGE: 5294701) Length = 9902 subunit Length = 2465 67 AC020917.4 AC020917 Homo NM_016270.2 Homo sapiens kruppel-like Hs.107740 Kruppel-like KLF2 sapiens factor 2 (lung) (KLF2), factor 2 chromosome 19 mRNA Length = 1655 (lung) clone CTD-2013N17, complete sequence Length = 151088 68 IMAGE: 2018147 69 Hs.100431 Chemokine CXCL13 (C—X—C motif) ligand 13 (B- cell chemoattractant) 70 AC116552.2 Homo sapiens Hs.507185 Zinc finger ZFPM1 chromosome 16 protein, clone RP11-21B21, multitype 1 complete sequence Length = 176797 71 Hs.473218 Phosphatase PHACTR3 and actin regulator 3 72 AY358388.1 Homo sapiens clone NM_030945.2 Homo sapiens C1q and Hs.171929 C1q and C1QTNF3 DNA44686 CTRP3 tumor necrosis factor tumor (UNQ753) mRNA, related protein 3 necrosis complete cds (C1QTNF3), transcript factor related Length = 1712 variant 1, mRNA protein 3 Length = 3570 73 Hs.280881 Cyclin- CDKL1 dependent kinase-like 1 (CDC2- related kinase) 74 AC012236.12 Homo sapiens Hs.558722 Hypothetical chromosome 15, LOC283710 clone RP11-16E12, complete sequence Length = 173729 75 AC006230.11 AC006230 Homo sapiens chromosome 4 clone C0287J14 map 4p16, complete sequence Length = 166998 76 AC112504.6 Homo sapiens 3 Hs.477789 ATPase, ATP1B3 BAC RP11-271K21 Na+/K+ (Roswell Park transporting, Cancer Institute beta 3 Human BAC Library) polypeptide complete sequence Length = 215077 77 Hs.170726 Transcribed locus 78 AF028823.2 AF028823 Homo NM_014604.2 Homo sapiens Tax1 Hs.12956 Tax1 (human TAX1BP3 sapiens Tax (human T-cell leukemia T-cell interaction protein 1 virus type I) binding protein leukemia mRNA, complete cds 3 (TAX1BP3), mRNA virus type I) Length = 1451 Length = 1421 binding protein 3 79 BC008062.2 Homo sapiens basic NM_001207.3 Homo sapiens basic Hs.560854 Transcribed transcription factor 3, transcription factor 3 locus mRNA (cDNA clone (BTF3), mRNA Length = 895 MGC: 2209 IMAGE: 2966788), complete cds Length = 865 80 BC104562.1 Bos taurus cDNA NM_003295.1 Homo sapiens tumor Hs.527980 DUTP DUT clone MGC: 128232 protein, translationally- pyrophosphatase IMAGE: 7948168, controlled 1 (TPT1), mRNA complete cds Length = 830 Length = 861 81 IMAGE: 1915051 82 BC080645.1 Homo sapiens ring Hs.436922 Ret finger RFP2 finger protein 187, protein 2 mRNA (cDNA clone IMAGE: 5093646) Length = 1516 83 BC001936.1 Homo sapiens NM_004323.3 Homo sapiens BCL2- Hs.377484 BCL2- BAG1 BCL2-associated associated athanogene associated athanogene, mRNA (BAG1), mRNA athanogene (cDNA clone Length = 3858 MGC: 4060 IMAGE: 2823774), complete cds Length = 1307 84 BC005831.2 Homo sapiens T-cell NM_021966.1 Homo sapiens T-cell Hs.2484 T-cell TCL1A leukemia/lymphoma leukemia/lymphoma 1A leukemia/lymphoma 1A, mRNA (cDNA (TCL1A), mRNA 1A clone MGC: 2170 Length = 1324 IMAGE: 2966563), complete cds Length = 1231 85 Hs.200413 Transmembrane TMED8 emp24 protein transport domain containing 8 86 AC004854.3 Homo sapiens PAC clone RP4-673M15 from 7, complete sequence Length = 98697 87 L29065.1 HUMBPA02 Human XM_612661.2 PREDICTED: Bos taurus Hs.558424 Cold shock CSDA DNA-binding protein similar to muscle Y-box domain A gene, exon 2 protein YB2 (LOC533297), protein A Length = 459 mRNA Length = 2010 88 BC035128.1 Homo sapiens cDNA NM_005962.4 Homo sapiens MAX Hs.501023 MAX MXI1 clone interactor 1 (MXI1), interactor 1 IMAGE: 5263647, transcript variant 1, mRNA partial cds Length = 3272 Length = 2756 89 AC013272.5 Homo sapiens BAC XM_530502.1 PREDICTED: Pan Hs.546387 Hypothetical DKFZp434N062 clone RP11-401C13 troglodytes LOC459556 protein from 2, complete (LOC459556), mRNA DKFZp434N062 sequence Length = 644 Length = 172705 90 Hs.213065 Hypothetical LOC158257 protein LOC158257 91 BC053070.1 Mus musculus ring NM_052916.1 Homo sapiens ring finger Hs.500643 Ring finger RNF157 finger protein 157, protein 157 (RNF157), protein 157 mRNA (cDNA clone mRNA Length = 3570 IMAGE: 6401088) Length = 4436 92 Hs.2316 SRY (sex SOX9 determining region Y)- box 9 (campomelic dysplasia, autosomal sex-reversal) 93 Hs.397705 Calmodulin CAMTA1 binding transcription activator 1 94 Hs.349656 Scavenger SCARB2 receptor class B, member 2 95 AC098616.2 Homo sapiens NM_022461.2 Homo sapiens 5- Hs.444724 5-azacytidine AZI2 chromosome 3 clone azacytidine induced 2 induced 2 RP11-279I18, (AZI2), mRNA complete sequence Length = 3113 Length = 159629 96 BC016755.1 Homo sapiens NM_000186.2 Homo sapiens complement Hs.363396 Complement CFH complement factor factor H (CFH), transcript factor H H-related 1, mRNA variant 1, mRNA (cDNA clone Length = 4004 MGC: 13525 IMAGE: 3934474), complete cds Length = 1296 97 AC146430.4 Pan troglodytes BAC Hs.490817 Hypothetical VIPR2 clone RP43-21F8 protein from 7, complete LOC154822 sequence Length = 179251 98 BC016003.1 Homo sapiens NM_001009567.1 Homo sapiens mannose Hs.461247 Mannose MRC1L1 mannose receptor, C receptor, C type 1-like 1 receptor, C type 1, mRNA (cDNA (MRC1L1), mRNA type 1 clone Length = 5171 IMAGE: 4618280), with apparent retained intron Length = 1618 99 BC000954.1 Homo sapiens NM_007276.3 Homo sapiens chromobox Hs.381189 Chromobox CBX3 chromobox homolog homolog 3 (HP1 gamma homolog 3 3 (HP1 gamma homolog, Drosophila) (HP1 gamma homolog, (CBX3), transcript variant 1, homolog, Drosophila), mRNA Length = 1837 Drosophila) transcript variant 1, mRNA (cDNA clone MGC: 4912 IMAGE: 3450099), complete cds Length = 1833 100 BC040494.1 Homo sapiens DnaJ NM_006736.4 Homo sapiens DnaJ Hs.77768 DnaJ DNAJB2 (Hsp40) homolog, (Hsp40) homolog, (Hsp40) subfamily B, member subfamily B, member 2 homolog, 2, mRNA (cDNA (DNAJB2), mRNA subfamily B, clone Length = 3041 member 2 IMAGE: 5297011), with apparent retained intron Length = 4397 101 U21049.1 HSU21049 Homo NM_005764.3 Homo sapiens PDZK1 Hs.431099 PDZK1 MAP17 sapiens DD96 interacting protein 1 interacting mRNA, complete cds (PDZK1IP1), mRNA protein 1 Length = 927 Length = 894 102 BC012133.1 Homo sapiens NM_006058.2 Homo sapiens TNFAIP3 Hs.355141 TNFAIP3 TNIP1 TNFAIP3 interacting interacting protein 1 interacting protein 1, mRNA (TNIP1), mRNA protein 1 (cDNA clone Length = 2921 MGC: 20223 IMAGE: 4549542), complete cds Length = 2842 103 BC000312.2 Homo sapiens cyclin- NM_078467.1 Homo sapiens cyclin- Hs.370771 Cyclin- CDKN1A dependent kinase dependent kinase inhibitor dependent inhibitor 1A (p21, 1A (p21, Cip1) (CDKN1A), kinase Cip1), transcript transcript variant 2, mRNA inhibitor 1A variant 2, mRNA Length = 2281 (p21, Cip1) (cDNA clone MGC: 8428 IMAGE: 2821049), complete cds Length = 2265 104 BC014460.1 Homo sapiens NM_001911.2 Homo sapiens cathepsin G Hs.421724 Cathepsin G CTSG cathepsin G, mRNA (CTSG), mRNA (cDNA clone Length = 924 MGC: 23078 IMAGE: 4859911), complete cds Length = 901 105 BC074817.2 Homo sapiens NM_001972.2 Homo sapiens elastase 2, Hs.99863 Elastase 2, ELA2 elastase 2, neutrophil (ELA2), mRNA neutrophil neutrophil, mRNA Length = 938 (cDNA clone MGC: 103928 IMAGE: 30915320), complete cds Length = 901 106 L33930.1 HUMCD24B Homo NM_013230.2 Homo sapiens CD24 Hs.375108 CD24 CD24 sapiens CD24 signal antigen (small cell lung antigen transducer mRNA, carcinoma cluster 4 (small cell complete cds and 3 antigen) (CD24), mRNA lung region Length = 2116 Length = 2194 carcinoma cluster 4 antigen) 107 BC056250.1 Homo sapiens leptin NM_017526.2 Homo sapiens leptin Hs.23581 Leptin LEPR receptor overlapping receptor overlapping receptor transcript, mRNA transcript (LEPROT), (cDNA clone mRNA Length = 1147 MGC: 61988 IMAGE: 4328021), complete cds Length = 1092 108 AF176043.1 Homo sapiens NM_181526.1 Homo sapiens myosin, light Hs.504687 Elongation MYL9 regulatory myosin polypeptide 9, regulatory factor Tu light chain short (MYL9), transcript variant 2, family protein version mRNA, mRNA Length = 1044 alternatively spliced, complete cds Length = 971 109 BC093965.1 Homo sapiens NM_002620.1 Homo sapiens platelet Hs.72933 Platelet PF4V1 platelet factor 4 factor 4 variant 1 (PF4V1), factor 4 (chemokine (C—X—C mRNA Length = 755 variant 1 motif) ligand 4), mRNA (cDNA clone MGC: 121000 IMAGE: 7939810), complete cds Length = 338 110 BC093965.1 Homo sapiens NM_002619.1 Homo sapiens platelet Hs.81564 Platelet PF4 platelet factor 4 factor 4 (chemokine (C—X—C factor 4 (chemokine (C—X—C motif) ligand 4) (PF4), (chemokine motif) ligand 4), mRNA Length = 439 (C—X—C motif) mRNA (cDNA clone ligand 4) MGC: 121000 IMAGE: 7939810), complete cds Length = 338 111 BC028217.1 Homo sapiens pro- NM_002704.2 Homo sapiens pro-platelet Hs.2164 Pro-platelet PPBP platelet basic protein basic protein (chemokine basic protein (chemokine (C—X—C (C—X—C motif) ligand 7) (chemokine motif) ligand 7), (PPBP), mRNA (C—X—C motif) mRNA (cDNA clone Length = 715 ligand 7) MGC: 40008 IMAGE: 5214257), complete cds Length = 703 112 BC028217.1 Homo sapiens pro- NM_002704.2 Homo sapiens pro-platelet Hs.2164 Pro-platelet PPBP platelet basic protein basic protein (chemokine basic protein (chemokine (C—X—C (C—X—C motif) ligand 7) (chemokine motif) ligand 7), (PPBP), mRNA (C—X—C motif) mRNA (cDNA clone Length = 715 ligand 7) MGC: 40008 IMAGE: 5214257), complete cds Length = 703 113 AC003043.1 AC003043 Homo NM_000419.2 Homo sapiens integrin, Hs.411312 Integrin, ITGA2B sapiens alpha 2b (platelet alpha 2b chromosome 17, glycoprotein IIb of IIb/IIIa (platelet clone HRPC1067M6, complex, antigen CD41B) glycoprotein complete sequence (ITGA2B), mRNA IIb of IIb/IIIa Length = 139488 Length = 3334 complex, antigen CD41B) 114 BC093965.1 Homo sapiens NM_002619.1 Homo sapiens platelet Hs.81564 Platelet PF4 platelet factor 4 factor 4 (chemokine (C—X—C factor 4 (chemokine (C—X—C motif) ligand 4) (PF4), (chemokine motif) ligand 4), mRNA Length = 439 (C—X—C motif) mRNA (cDNA clone ligand 4) MGC: 121000 IMAGE: 7939810), complete cds Length = 338 115 BC013221.1 Homo sapiens NM_203339.1 Homo sapiens clusterin Hs.436657 Clusterin CLU clusterin (complement lysis inhibitor, (complement (complement lysis SP-40,40, sulfated lysis inhibitor, SP-40,40, glycoprotein 2, inhibitor, SP- sulfated glycoprotein testosterone-repressed 40,40, 2, testosterone- prostate message 2, sulfated repressed prostate apolipoprotein J) (CLU), glycoprotein message 2, transcript variant 2, mRNA 2, apolipoprotein J), Length = 2979 testosterone- mRNA (cDNA clone repressed IMAGE: 4149765) prostate Length = 1620 message 2, apolipoprotein J) 116 BC029972.1 Homo sapiens NM_203339.1 Homo sapiens clusterin Hs.559474 RPB11b2alpha clusterin (complement lysis inhibitor, protein (complement lysis SP-40,40, sulfated inhibitor, SP-40,40, glycoprotein 2, sulfated glycoprotein testosterone-repressed 2, testosterone- prostate message 2, repressed prostate apolipoprotein J) (CLU), message 2, transcript variant 2, mRNA apolipoprotein J), Length = 2979 mRNA (cDNA clone IMAGE: 4939961) Length = 2821 117 BC013221.1 Homo sapiens NM_203339.1 Homo sapiens clusterin Hs.436657 Clusterin CLU clusterin (complement lysis inhibitor, (complement (complement lysis SP-40,40, sulfated lysis inhibitor, SP-40,40, glycoprotein 2, inhibitor, SP- sulfated glycoprotein testosterone-repressed 40,40, 2, testosterone- prostate message 2, sulfated repressed prostate apolipoprotein J) (CLU), glycoprotein message 2, transcript variant 2, mRNA 2, apolipoprotein J), Length = 2979 testosterone- mRNA (cDNA clone repressed IMAGE: 4149765) prostate Length = 1620 message 2, apolipoprotein J) 118 Hs.144925 Transcribed locus 119 AC092959.6 Homo sapiens 3 XM_586391.2 PREDICTED: Bos taurus Hs.415766 Zic family ZIC4 BAC RP11-649A16 similar to zinc finger protein member 4 (Roswell Park of the cerebellum 4 Cancer Institute (LOC539312), mRNA Human BAC Library) Length = 2941 complete sequence Length = 179714 120 BC012293.1 Homo sapiens NM_020070.2 Homo sapiens Hs.546463 Similar to immunoglobulin immunoglobulin lambda- omega lambda-like like polypeptide 1 (IGLL1), protein polypeptide 1, transcript variant 1, mRNA transcript variant 1, Length = 901 mRNA (cDNA clone MGC: 21361 IMAGE: 4508892), complete cds Length = 853 121 AY358309.1 Homo sapiens clone NM_148967.1 Homo sapiens tumor Hs.462529 Tumor TNFRSF25 DNA58801 DR3 necrosis factor receptor necrosis (UNQ455) mRNA, superfamily, member 25 factor complete cds (TNFRSF25), transcript receptor Length = 1662 variant 4, mRNA superfamily, Length = 1503 member 25 122 Hs.179646 Hypothetical MGC35118 protein MGC35118 123 Hs.561568 Transcribed locus 124 AY422212.1 Homo sapiens NM_181806.2 Homo sapiens 2- Hs.104347 2- AASDH putative non- aminoadipic 6- aminoadipic ribosomal peptide semialdehyde 6- synthetase dehydrogenase (AASDH), semialdehyde NRPS1098 mRNA, mRNA Length = 3573 dehydrogenase complete cds Length = 3528 125 BC012506.1 Homo sapiens NM_000641.2 Homo sapiens interleukin Hs.467304 Interleukin IL11 interleukin 11, mRNA 11 (IL11), mRNA 11 (cDNA clone Length = 2354 MGC: 21360 IMAGE: 4476678), complete cds Length = 1201 126 AC080162.7 Homo sapiens BAC Hs.404914 ADAM ADAM17 clone RP11-400L8 metallopeptidase from 2, complete domain sequence 17 (tumor Length = 171653 necrosis factor, alpha, converting enzyme) 127 Hs.518614 Transcriptional MGC21874 adaptor 2 (ADA2 homolog, yeast)-beta 128 BC091477.1 Homo sapiens Yip1 NM_001031731.1 Homo sapiens Yip1 Hs.280741 Yip1 LOC90522 interacting factor interacting factor homolog interacting homolog B (S. cerevisiae), B (S. cerevisiae) (YIF1B), factor mRNA transcript variant 1, mRNA homolog B (cDNA clone Length = 956 (S. cerevisiae) MGC: 110904 IMAGE: 30344388), complete cds Length = 1217 129 1393148 130 AF521134.1 Homo sapiens tumor Hs.492555 Enhancer of e(y)2 antigen CML66 yellow 2 gene, short isoform homolog promoter region and (Drosophila) partial cds Length = 4283 131 Hs.567598 Transcribed locus 132 AC093415.2 Homo sapiens chromosome 3 clone RP11-586N22, complete sequence Length = 196641 133 BC019323.1 Homo sapiens NM_001024382.1 Homo sapiens Hs.82609 Hydroxymethylbilane HMBS hydroxymethylbilane hydroxymethylbilane synthase synthase, mRNA synthase (HMBS), (cDNA clone transcript variant 2, mRNA MGC: 4369 Length = 1428 IMAGE: 2822949), complete cds Length = 1536 134 BC007928.1 Homo sapiens NM_032910.2 Homo sapiens Hs.58149 Chromosome C21orf119 chromosome 21 chromosome 21 open 21 open open reading frame reading frame 119 reading 119, mRNA (cDNA (C21orf119), mRNA frame 119 clone MGC: 14136 Length = 838 IMAGE: 3945901), complete cds Length = 844 135 Hs.549607 CDNA clone IMAGE: 5757380 136 AC093635.4 Homo sapiens BAC clone RP11-191L17 from 2, complete sequence Length = 132032 137 AC073082.6 Homo sapiens BAC NM_006873.2 Homo sapiens stoned B- Hs.44385 TFIIA- ALF clone RP11-310N16 like factor (SBLF), mRNA alpha/beta- from 2, complete Length = 5822 like factor sequence Length = 177047 138 AC018545.14 Homo sapiens 3 Hs.52526 TSC22 KIAA0669 BAC RP11-145F16 domain (Roswell Park family, Cancer Institute member 2 Human BAC Library) complete sequence Length = 170359 139 AC005858.1 Homo sapiens Hs.386211 Transcribed 12q24.2 PAC RPCI3- locus 446N13 (Roswell Park Cancer Institute Human PAC Library) complete sequence Length = 135521 140 AY077696.1 Homo sapiens clone Hs.352631 Chromosome C21orf74 qd65g07 PRED16 21 open protein (PRED16) reading mRNA, complete cds frame 74 Length = 726 141 U19251.1 HSU19251 Homo NM_004536.1 Homo sapiens baculoviral Hs.558359 Baculoviral BIRC1 sapiens neuronal IAP repeat-containing 1 IAP repeat- apoptosis inhibitory (BIRC1), mRNA containing 1 protein mRNA, Length = 6133 complete cds Length = 6124 142 Hs.196578 Chromosome C10orf85 10 open reading frame 85 143 XM_513171.1 PREDICTED: Pan Hs.558906 Hypothetical LOC400745 troglodytes similar to protein BC036961 protein LOC149194 (LOC456593), mRNA Length = 2715 144 AC064836.7 Homo sapiens BAC Hs.541555 Transcribed clone RP11-686O6 locus from 2, complete sequence Length = 154754 145 Hs.127851 Chromosome 1 open reading frame 137 146 BC001017.1 Homo sapiens PDZ Hs.85862 PDZ and LIM PDLIM3 and LIM domain 3, domain 3 mRNA (cDNA clone MGC: 2005 IMAGE: 3345880), complete cds Length = 2819 147 AC005300.10 Homo sapiens NM_014339.3 Homo sapiens interleukin Hs.129751 Interleukin IL17R chromosome 22 17 receptor (IL17R), mRNA 17 receptor clone p143i13 map Length = 3429 22q11, complete sequence Length = 101269 148 AC110926.5 Homo sapiens BAC NM_006609.2 Homo sapiens mitogen- Hs.145605 Mitogen- MAP3K2 clone RP11-313N8 activated protein kinase activated from 2, complete kinase kinase 2 (MAP3K2), protein sequence mRNA Length = 3336 kinase Length = 193648 kinase kinase 2 149 AF327353.1 AF327353 Homo NM_018367.3 Homo sapiens Hs.23862 Phytoceramidase, PHCA sapiens alkaline phytoceramidase, alkaline alkaline dihydroceramidase (PHCA), mRNA SB89 mRNA, Length = 3473 complete cds Length = 3473 150 AC022898.11 Homo sapiens Hs.135183 Centaurin, CENTA1 chromosome 15, alpha 1 clone RP11-554D20, complete sequence Length = 200380 151 AF005887.1 AF005887 Homo NM_007348.2 Homo sapiens activating Hs.533771 STIP1 STUB1 sapiens ATF family transcription factor 6 homology member ATF6 (ATF6), mRNA and U-box (ATF6) mRNA, Length = 2488 containing complete cds protein 1 Length = 2474 152 Hs.147880 LOC440132 153 AC067945.4 Homo sapiens BAC NM_139266.1 Homo sapiens signal Hs.470943 Signal STAT1 clone RP11-629B4 transducer and activator of transducer from 2, complete transcription 1, 91 kDa and activator sequence (STAT1), transcript variant of Length = 162471 beta, mRNA Length = 2762 transcription 1, 91 kDa 154 BC035716.2 Homo sapiens NM_006084.3 Homo sapiens interferon- Hs.1706 Interferon- ISGF3G interferon-stimulated stimulated transcription stimulated transcription factor 3, factor 3, gamma 48 kDa transcription gamma 48 kDa, (ISGF3G), mRNA factor 3, mRNA (cDNA clone Length = 1584 gamma MGC: 46151 48 kDa IMAGE: 5588434), complete cds Length = 1593 155 AC138374.2 Homo sapiens NM_001572.2 Homo sapiens interferon Hs.166120 Interferon IRF7 chromosome 11, regulatory factor 7 (IRF7), regulatory clone CTD-2647G13, transcript variant a, mRNA factor 7 complete sequence Length = 1890 Length = 196424 156 BC008060.2 Homo sapiens cDNA NM_033307.2 Homo sapiens caspase 4, Hs.138378 Caspase 4, CASP4 clone apoptosis-related cysteine apoptosis- IMAGE: 2988427, peptidase (CASP4), related containing frame- transcript variant delta, cysteine shift errors mRNA Length = 1327 peptidase Length = 1291 157 AC093798.3 Homo sapiens BAC XM_498892.1 PREDICTED: Homo Hs.158920 LOC440852 clone RP11-306N14 sapiens LOC440852 from 2, complete (LOC440852), mRNA sequence Length = 618 Length = 233877 158 BC001079.2 Homo sapiens NM_024068.2 Homo sapiens hypothetical Hs.240170 Hypothetical MGC2731 hypothetical protein protein MGC2731 protein MGC2731, mRNA (MGC2731), mRNA MGC2731 (cDNA clone Length = 1332 MGC: 2731 IMAGE: 2822460), complete cds Length = 1332 159 BC011589.1 Homo sapiens NM_020530.3 Homo sapiens oncostatin M Hs.248156 Oncostatin M OSM oncostatin M, mRNA (OSM), mRNA (cDNA clone Length = 1880 MGC: 20461 IMAGE: 4548943), complete cds Length = 1869 160 Hs.310536 Histone HDAC8 deacetylase 8 161 AF109146.1 Homo sapiens C- NM_194447.1 Homo sapiens C-type lectin Hs.504657 C-type lectin CLECSF6 type lectin domain family 4, member A domain superfamily 6 (CLEC4A), transcript family 4, (CLECSF6) mRNA, variant 3, mRNA member A complete cds Length = 1171 Length = 1133 162 BC070085.1 Homo sapiens NM_000395.1 Homo sapiens colony Hs.285401 Colony CSF2RB colony stimulating stimulating factor 2 stimulating factor 2 receptor, receptor, beta, low-affinity factor 2 beta, low-affinity (granulocyte-macrophage) receptor, (granulocyte- (CSF2RB), mRNA beta, low- macrophage), mRNA Length = 2996 affinity (cDNA clone (granulocyte- MGC: 87425 macrophage) IMAGE: 30344148), complete cds Length = 4116 163 BC008678.1 Homo sapiens NM_000576.2 Homo sapiens interleukin 1, Hs.126256 Interleukin 1, IL1B interleukin 1, beta, beta (IL1B), mRNA beta mRNA (cDNA clone Length = 1498 MGC: 9216 IMAGE: 3875593), complete cds Length = 1522 164 BC008678.1 Homo sapiens NM_000576.2 Homo sapiens interleukin 1, Hs.126256 Interleukin 1, IL1B interleukin 1, beta, beta (IL1B), mRNA beta mRNA (cDNA clone Length = 1498 MGC: 9216 IMAGE: 3875593), complete cds Length = 1522 165 BC012181.1 Homo sapiens furin NM_002569.2 Homo sapiens furin (paired Hs.513153 Furin (paired FURIN (paired basic amino basic amino acid cleaving basic amino acid cleaving enzyme) (FURIN), mRNA acid cleaving enzyme), mRNA Length = 4180 enzyme) (cDNA clone MGC: 20463 IMAGE: 4550620), complete cds Length = 4033 166 BC001506.2 Homo sapiens CD59 NM_203329.1 Homo sapiens CD59 Hs.278573 CD59 CD59 antigen p18-20 antigen p18-20 (antigen antigen p18-20 (antigen identified by identified by monoclonal (antigen monoclonal antibodies 16.3A5, EJ16, identified by antibodies 16.3A5, EJ30, EL32 and G344) monoclonal EJ16, EJ30, EL32 (CD59), transcript variant 3, antibodies and G344), transcript mRNA Length = 7682 16.3A5, variant 2, mRNA EJ16, EJ30, (cDNA clone EL32 and MGC: 2354 G344) IMAGE: 2988140), complete cds Length = 1937 167 BC106764.1 Homo sapiens cDNA NM_003853.2 Homo sapiens interleukin Hs.158315 Interleukin IL18RAP clone MGC: 120589 18 receptor accessory 18 receptor IMAGE: 40026248, protein (IL18RAP), mRNA accessory complete cds Length = 2668 protein Length = 1891 168 AC007248.4 Homo sapiens BAC NM_003855.2 Homo sapiens interleukin Hs.469521 Interleukin IL18R1 clone RP11-315O22 18 receptor 1 (IL18R1), 18 receptor 1 from 2, complete mRNA Length = 3522 sequence Length = 201535 Features flanking this part of subject sequence: 1411 bp at 5 side: unknown 24927 bp at 3 side: unknown 169 AC007248.4 Homo sapiens BAC NM_003855.2 Homo sapiens interleukin Hs.469521 Interleukin IL18R1 clone RP11-315O22 18 receptor 1 (IL18R1), 18 receptor 1 from 2, complete mRNA Length = 3522 sequence Length = 201535 Features flanking this part of subject sequence: 1401 bp at 5 side: unknown 24927 bp at 3 side: unknown 170 BC016281.1 Homo sapiens NM_004049.2 Homo sapiens BCL2- Hs.227817 BCL2-related BCL2A1 BCL2-related protein related protein A1 protein A1 A1, mRNA (cDNA (BCL2A1), mRNA clone MGC: 8991 Length = 885 IMAGE: 3920808), complete cds Length = 829 171 M28585.1 HUMIFNN Human NM_002173.1 Homo sapiens interferon, Hs.56303 Interferon, IFNA16 leukocyte interferon- alpha 16 (IFNA16), mRNA alpha 16 alpha mRNA, Length = 941 complete cds, clone pIFN105 Length = 941 172 BC030205.1 Homo sapiens tumor NM_007115.2 Homo sapiens tumor Hs.437322 Tumor TNFAIP6 necrosis factor, necrosis factor, alpha- necrosis alpha-induced induced protein 6 factor, alpha- protein 6, mRNA (TNFAIP6), mRNA induced (cDNA clone Length = 1440 protein 6 MGC: 34404 IMAGE: 5208773), complete cds Length = 1430 173 AC007198.6 AC007198 Homo NM_003268.3 Homo sapiens toll-like Hs.114408 Toll-like TLR5 sapiens, clone receptor 5 (TLR5), mRNA receptor 5 18_A_13, complete Length = 3369 sequence Length = 166977 174 BC026025.1 Homo sapiens NM_017817.1 Homo sapiens RAB20, Hs.508720 RAB20, RAB20 RAB20, member member RAS oncogene member RAS oncogene family (RAB20), mRNA RAS family, mRNA (cDNA Length = 1530 oncogene clone MGC: 39156 family IMAGE: 4636491), complete cds Length = 1541 175 BC063827.1 Homo sapiens NM_002957.3 Homo sapiens retinoid X Hs.20084 Retinoid X RXRA retinoid X receptor, receptor, alpha (RXRA), receptor, alpha, mRNA (cDNA mRNA Length = 5449 alpha clone IMAGE: 6528306), partial cds Length = 5534 176 BC018058.1 Homo sapiens tumor NM_172014.1 Homo sapiens tumor Hs.129708 Tumor TNFSF14 necrosis factor necrosis factor (ligand) necrosis (ligand) superfamily, superfamily, member 14 factor member 14, mRNA (TNFSF14), transcript (ligand) (cDNA clone variant 2, mRNA superfamily, MGC: 26477 Length = 1395 member 14 IMAGE: 4793299), complete cds Length = 1211 177 AF205589.5 Homo sapiens NM_024531.3 Homo sapiens G protein- Hs.6459 G protein- GPR172A chromosome 8 clone coupled receptor 172A coupled CTA-393G12 map (GPR172A), mRNA receptor qtel, complete Length = 1952 172A sequence Length = 143847 178 BC065291.1 Homo sapiens ras NM_012249.2 Homo sapiens ras homolog Hs.549125 Ras homolog RHOQ homolog gene family, gene family, member Q gene family, member Q, mRNA (RHOQ), mRNA member Q (cDNA clone Length = 2127 IMAGE: 6061807), partial cds Length = 1922 179 AY005151.1 Homo sapiens BID S NM_197967.1 Homo sapiens BH3 Hs.474150 BH3 BID (BID) mRNA, interacting domain death interacting complete cds agonist (BID), transcript domain Length = 854 variant 3, mRNA death Length = 2144 agonist 180 BC010931.1 Homo sapiens Hs.153629 MADS box MEF2B MADS box transcription transcription enhancer enhancer factor 2, factor 2, polypeptide B polypeptide (myocyte enhancer B (myocyte factor 2B), mRNA enhancer (cDNA clone factor 2B) IMAGE: 4280324), complete cds Length = 1020 181 BC017197.2 Homo sapiens NM_182763.1 Homo sapiens myeloid cell Hs.532826 Myeloid cell MCL1 myeloid cell leukemia leukemia sequence 1 leukemia sequence 1 (BCL2- (BCL2-related) (MCL1), sequence 1 related), transcript transcript variant 2, mRNA (BCL2- variant 1, mRNA Length = 3772 related) (cDNA clone MGC: 1839 IMAGE: 3138465), complete cds Length = 3944 182 NM_001560.2 Homo sapiens interleukin Hs.496646 Interleukin IL13RA1 13 receptor, alpha 1 13 receptor, (IL13RA1), mRNA alpha 1 Length = 4006 183 BC072446.1 Homo sapiens NM_198057.2 Homo sapiens TSC22 Hs.522074 TSC22 DSIPI TSC22 domain domain family, member 3 domain family, member 3, (TSC22D3), transcript family, transcript variant 2, variant 1, mRNA member 3 mRNA (cDNA clone Length = 2312 MGC: 90321 IMAGE: 6165765), complete cds Length = 1959 184 AC004962.1 AC004962 Homo Hs.298858 CDNA sapiens PAC clone FLJ42664 RP5-1099N7 from 1, fis, clone complete sequence BRAMY2019985 Length = 143749 185 IMAGE: 2210177 186 AC090827.11 Homo sapiens Hs.301974 Low density LRP12 chromosome 8, lipoprotein- clone CTD-2594K21, related complete sequence protein 12 Length = 135010 187 IMAGE: 1371638 188 BC005821.2 Homo sapiens NM_000314.3 Homo sapiens Hs.500466 Phosphatase PTEN phosphatase and phosphatase and tensin and tensin tensin homolog homolog (mutated in homolog (mutated in multiple multiple advanced cancers (mutated in advanced cancers 1) (PTEN), mRNA multiple 1), mRNA (cDNA Length = 3416 advanced clone MGC: 11227 cancers 1) IMAGE: 3937787), complete cds Length = 2357 189 AY455929.1 Homo sapiens NM_004054.2 Homo sapiens complement Hs.527839 Complement C3AR1 complement component 3a receptor 1 component component 3a (C3AR1), mRNA 3a receptor 1 receptor 1 (C3AR1) Length = 1985 gene, complete cds Length = 12053 190 BC003091.1 Homo sapiens NM_002856.1 Homo sapiens poliovirus Hs.326371 Poliovirus PVRL2 poliovirus receptor- receptor-related 2 receptor- related 2 (herpesvirus entry mediator related 2 (herpesvirus entry B) (PVRL2), mRNA (herpesvirus mediator B), mRNA Length = 1928 entry (cDNA clone mediator B) MGC: 1349 IMAGE: 3503222), complete cds Length = 1968 191 AY834276.1 Homo sapiens NM_145686.2 Homo sapiens mitogen- Hs.431550 Mitogen- MAP4K4 mitogen-activated activated protein kinase activated protein kinase kinase kinase kinase kinase 4 protein kinase kinase 4 (MAP4K4), transcript kinase isoform (MAP4K4) variant 2, mRNA kinase mRNA, complete Length = 7495 kinase cds, alternatively kinase 4 spliced Length = 3129 192 AC158549.8 Mus musculus NM_000684.1 Homo sapiens adrenergic, Hs.99913 Adrenergic, ADRB1 chromosome 19, beta-1-, receptor (ADRB1), beta-1-, clone RP24-216K4, mRNA Length = 1723 receptor complete sequence Length = 195500 193 BC038711.1 Homo sapiens UDP- XM_592193.2 PREDICTED: Bos taurus Hs.304249 UDP-glucose UGCG glucose ceramide similar to Ceramide ceramide glucosyltransferase, glucosyltransferase glucosyltransferase mRNA (cDNA clone (Glucosylceramide MGC: 33797 synthase) (GCS) (UDP- IMAGE: 5295561), glucose: N-acylsphingosine complete cds D-glucosyltransferase) Length = 1730 (UDP-glucose ceramide glucosyltransferase) (GLCT-1) (LOC514357), mRNA Length = 1433 194 AC021754.6 Homo sapiens NG_005156.1 Homo sapiens creatine Hs.253260 Cation chromosome 15 kinase, mitochondrial 1 channel, clone RP11-263I19 duplicated region sperm map 15q15, (CKMT1@) on associated 2 complete sequence chromosome 15 pseudogene Length = 172474 Length = 239654 Features flanking this part of subject sequence: 5819 bp at 5 side: creatine kinase, mitochondrial 1A precursor 41564 bp at 3 side: protein disulfide 195 Hs.421340 Chromosome C9orf98 9 open reading frame 98 196 IMAGE: 144802 197 AC012653.8 AC012653 Homo Hs.104792 Transcribed sapiens locus chromosome 15 clone RP11-86K22 map 15q21.3, complete sequence Length = 190420 198 BC064689.1 Homo sapiens tumor NM_006290.2 Homo sapiens tumor Hs.211600 Tumor TNFAIP3 necrosis factor, necrosis factor, alpha- necrosis alpha-induced induced protein 3 factor, alpha- protein 3, mRNA (TNFAIP3), mRNA induced (cDNA clone Length = 4446 protein 3 IMAGE: 30345989), complete cds Length = 5457 199 BC005080.1 Homo sapiens NM_052815.1 Homo sapiens immediate Hs.76095 Immediate IER3 immediate early early response 3 (IER3), early response 3, transcript variant long, response 3 transcript variant mRNA Length = 1345 short, mRNA (cDNA clone MGC: 13037 IMAGE: 3617088), complete cds Length = 1240 200 BC009015.1 Homo sapiens serpin NM_030666.2 Homo sapiens serpin Hs.381167 Serpin SERPINB1 peptidase inhibitor, peptidase inhibitor, clade B peptidase clade B (ovalbumin), (ovalbumin), member 1 inhibitor, member 1, mRNA (SERPINB1), mRNA clade B (cDNA clone Length = 1310 (ovalbumin), MGC: 9340 member 1 IMAGE: 3456154), complete cds Length = 1310 201 AF531102.1 Homo sapiens NM_000877.2 Homo sapiens interleukin 1 Hs.557403 Interleukin 1 IL1R1 interleukin 1 receptor, type I (IL1R1), receptor, receptor, type I mRNA Length = 4909 type I (IL1R1) gene, complete cds Length = 27864 202 AF531102.1 Homo sapiens NM_000877.2 Homo sapiens interleukin 1 Hs.557403 Interleukin 1 IL1R1 interleukin 1 receptor, type I (IL1R1), receptor, receptor, type I mRNA Length = 4909 type I (IL1R1) gene, complete cds Length = 27864 203 BC105285.1 Homo sapiens NM_004607.1 Homo sapiens tubulin- Hs.495912 Dystrophin DMD tubulin-specific specific chaperone a (muscular chaperone a, mRNA (TBCA), mRNA dystrophy, (cDNA clone Length = 574 Duchenne MGC: 104402 and Becker IMAGE: 6702573), types) complete cds Length = 590 204 BC000866.1 Homo sapiens TIMP NM_003254.2 Homo sapiens TIMP Hs.522632 TIMP TIMP1 metallopeptidase metallopeptidase inhibitor 1 metallopeptidase inhibitor 1, mRNA (TIMP1), mRNA inhibitor 1 (cDNA clone Length = 931 MGC: 5065 IMAGE: 3460153), complete cds Length = 881 205 BC025733.1 Homo sapiens Fas NM_003824.2 Homo sapiens Fas Hs.86131 Fas FADD (TNFRSF6)- (TNFRSF6)-associated via (TNFRSF6)- associated via death death domain (FADD), associated domain, mRNA mRNA Length = 1873 via death (cDNA clone domain IMAGE: 5203692) Length = 1689 206 BT019443.1 Homo sapiens ras- NM_005052.2 Homo sapiens ras-related Hs.45002 Ras-related RAC3 related C3 botulinum C3 botulinum toxin C3 botulinum toxin substrate 3 (rho substrate 3 (rho family, toxin family, small GTP small GTP binding protein substrate 3 binding protein Rac3) Rac3) (RAC3), mRNA (rho family, mRNA, complete cds Length = 1077 small GTP Length = 579 binding protein Rac3) 207 AF517525.1 Homo sapiens cyclin NM_001760.2 Homo sapiens cyclin D3 Hs.534307 Cyclin D3 CCND3 D3 (CCND3) gene, (CCND3), mRNA complete cds Length = 2095 Length = 8987 208 AF111168.2 AF111168 Homo NM_004863.2 Homo sapiens serine Hs.435661 Serine SPTLC2 sapiens serine palmitoyltransferase, long palmitoyltransferase, palmitoyl transferase, chain base subunit 2 long subunit II gene, (SPTLC2), mRNA chain base complete cds; and Length = 7250 subunit 2 unknown genes Length = 231464 Features flanking this part of subject sequence: 8949 bp at 5 side: unknown 4488 bp at 3 side: serine palmitoyl transferase, subunit II 209 BC051281.1 Homo sapiens NM_203416.1 Homo sapiens CD163 Hs.504641 CD163 CD163 CD163 antigen, antigen (CD163), transcript antigen transcript variant 1, variant 2, mRNA mRNA (cDNA clone Length = 3728 MGC: 59680 IMAGE: 6280265), complete cds Length = 3780 210 AC068946.4 Homo sapiens BAC NM_024293.2 Homo sapiens Hs.516707 Chromosome C2orf17 clone RP11-803J6 chromosome 2 open 2 open from 2, complete reading frame 17 reading sequence (C2orf17), mRNA frame 17 Length = 172260 Length = 2615 211 AY525612.1 Macaca mulatta Toll- NM_003264.3 Homo sapiens toll-like Hs.519033 Toll-like TLR2 like receptor 2 receptor 2 (TLR2), mRNA receptor 2 (TLR2) mRNA, Length = 3417 partial cds Length = 434 212 BC033756.1 Homo sapiens toll- NM_003264.3 Homo sapiens toll-like Hs.519033 Toll-like TLR2 like receptor 2, receptor 2 (TLR2), mRNA receptor 2 mRNA (cDNA clone Length = 3417 MGC: 45301 IMAGE: 5213439), complete cds Length = 2756 213 AY124010.1 Homo sapiens interleukin 1 receptor, type II (IL1R2) gene, complete cds Length = 23160 214 BC022463.1 Homo sapiens dual NM_004417.2 Homo sapiens dual Hs.171695 Dual DUSP1 specificity specificity phosphatase 1 specificity phosphatase 1, (DUSP1), mRNA phosphatase 1 mRNA (cDNA clone Length = 2015 MGC: 26153 IMAGE: 4794895), complete cds Length = 2026 215 BC012346.1 Homo sapiens cDNA NM_173343.1 Homo sapiens interleukin 1 Hs.25333 Interleukin 1 IL1R2 clone receptor, type II (IL1R2), receptor, IMAGE: 4562827, transcript variant 2, mRNA type II containing frame- Length = 1436 shift errors Length = 1430 216 Hs.511486 Similar to 60S ribosomal protein L37a 217 J05070.1 HUM4COLA Human NM_004994.2 Homo sapiens matrix Hs.297413 Matrix MMP9 type IV collagenase metallopeptidase 9 metallopeptidase 9 mRNA, complete cds (gelatinase B, 92 kDa (gelatinase Length = 2334 gelatinase, 92 kDa type IV B, 92 kDa collagenase) (MMP9), gelatinase, mRNA Length = 2387 92 kDa type IV collagenase) 218 AF134726.1 Homo sapiens BAC NM_005345.4 Homo sapiens heat shock Hs.520028 Heat shock HSPA1A clone 215O12 NG35, 70 kDa protein 1A 70 kDa NG36, G9A, NG22, (HSPA1A), mRNA protein 1A G9, HSP70-2, Length = 2383 HSP70-1, HSP70- HOM, snRNP, G7A, NG37, NG23, and MutSH5 genes, complete cds Length = 180283 219 AY135686.1 Homo sapiens NM_001924.2 Homo sapiens growth Hs.80409 Growth GADD45A growth arrest and arrest and DNA-damage- arrest and DNA-damage- inducible, alpha DNA- inducible, alpha (GADD45A), mRNA damage- (GADD45A) gene, Length = 1355 inducible, complete cds alpha Length = 4417 220 BC002755.2 Homo sapiens MAP NM_003684.3 Homo sapiens MAP kinase Hs.371594 MAP kinase MKNK1 kinase interacting interacting serine/threonine interacting serine/threonine kinase 1 (MKNK1), serine/threonine kinase 1, mRNA transcript variant 1, mRNA kinase 1 (cDNA clone Length = 2736 MGC: 3690 IMAGE: 3629765), complete cds Length = 2736 221 AC004525.1 HUAC004525 Homo NM_000418.2 Homo sapiens interleukin 4 Hs.513457 Interleukin 4 IL4R sapiens receptor (IL4R), transcript receptor Chromosome 16 variant 1, mRNA BAC clone Length = 3678 CIT987SK-582J2, complete sequence Length = 130020 222 BC053871.2 Homo sapiens NM_005587.1 Homo sapiens MADS box Hs.268675 MADS box MEF2A MADS box transcription enhancer transcription transcription factor 2, polypeptide A enhancer enhancer factor 2, (myocyte enhancer factor factor 2, polypeptide A 2A) (MEF2A), mRNA polypeptide (myocyte enhancer Length = 2975 A (myocyte factor 2A), mRNA enhancer (cDNA clone factor 2A) MGC: 61461 IMAGE: 5555678), complete cds Length = 5054 223 BC101075.2 Homo sapiens cDNA NM_016610.2 Homo sapiens toll-like Hs.272410 Toll-like TLR8 clone MGC: 119599 receptor 8 (TLR8), receptor 8 IMAGE: 40008788, transcript variant 1, mRNA complete cds Length = 3468 Length = 3500 224 BC017292.1 Homo sapiens flotillin NM_004475.1 Homo sapiens flotillin 2 Hs.514038 Flotillin 2 FLOT2 2, mRNA (cDNA (FLOT2), mRNA clone MGC: 29558 Length = 2488 IMAGE: 4907083), complete cds Length = 2481 225 AY619687.1 Homo sapiens NM_001629.2 Homo sapiens Hs.507658 Arachidonate ALOX5AP arachidonate 5- arachidonate 5- 5- lipoxygenase- lipoxygenase-activating lipoxygenase- activating protein protein (ALOX5AP), mRNA activating (ALOX5AP) gene, Length = 873 protein complete cds Length = 32877 226 BC001146.1 Homo sapiens flotillin NM_005803.2 Homo sapiens flotillin 1 Hs.179986 Flotillin 1 FLOT1 1, mRNA (cDNA (FLOT1), mRNA clone MGC: 1199 Length = 1839 IMAGE: 3534771), complete cds Length = 1610 227 AF177765.1 AF177765 Homo NM_138556.1 Homo sapiens toll-like Hs.174312 Toll-like TLR4 sapiens toll-like receptor 4 (TLR4), receptor 4 receptor 4 (TLR4) transcript variant 2, mRNA gene, TLR4A allele, Length = 3767 complete cds Length = 18974 228 L35263.1 HUMCSBP1 Human NM_139014.1 Homo sapiens mitogen- Hs.485233 Mitogen- MAPK14 CSaids binding activated protein kinase 14 activated protein (CSBP1) (MAPK14), transcript protein mRNA, complete cds variant 4, mRNA kinase 14 Length = 3757 Length = 3679 229 L35263.1 HUMCSBP1 Human NM_139014.1 Homo sapiens mitogen- Hs.485233 Mitogen- MAPK14 CSaids binding activated protein kinase 14 activated protein (CSBP1) (MAPK14), transcript protein mRNA, complete cds variant 4, mRNA kinase 14 Length = 3757 Length = 3679 230 U19775.1 HSU19775 Human NM_139013.1 Homo sapiens mitogen- Hs.485233 Mitogen- MAPK14 MAP kinase Mxi2 activated protein kinase 14 activated (MXI2) mRNA, (MAPK14), transcript protein complete cds variant 3, mRNA kinase 14 Length = 993 Length = 1312 231 BC031574.1 Homo sapiens NM_139014.1 Homo sapiens mitogen- Hs.485233 Mitogen- MAPK14 mitogen-activated activated protein kinase 14 activated protein kinase 14, (MAPK14), transcript protein transcript variant 2, variant 4, mRNA kinase 14 mRNA (cDNA clone Length = 3679 MGC: 34610 IMAGE: 5181064), complete cds Length = 3751 232 M69043.1 HUMMAD3A Homo NM_020529.1 Homo sapiens nuclear Hs.81328 Nuclear NFKBIA sapiens MAD-3 factor of kappa light factor of mRNA encoding lkB- polypeptide gene enhancer kappa light like activity, complete in B-cells inhibitor, alpha polypeptide cds Length = 1550 (NFKBIA), mRNA gene Length = 1550 enhancer in B-cells inhibitor, alpha 233 BC004983.1 Homo sapiens NM_020529.1 Homo sapiens nuclear Hs.81328 Nuclear NFKBIA nuclear factor of factor of kappa light factor of kappa light polypeptide gene enhancer kappa light polypeptide gene in B-cells inhibitor, alpha polypeptide enhancer in B-cells (NFKBIA), mRNA gene inhibitor, alpha, Length = 1550 enhancer in mRNA (cDNA clone B-cells MGC: 3942 inhibitor, IMAGE: 2957970), alpha complete cds Length = 1566 234 BC101075.2 Homo sapiens cDNA NM_016610.2 Homo sapiens toll-like Hs.272410 Toll-like TLR8 clone MGC: 119599 receptor 8 (TLR8), receptor 8 IMAGE: 40008788, transcript variant 1, mRNA complete cds Length = 3468 Length = 3500 235 BC068476.1 Homo sapiens numb NM_001005745.1 Homo sapiens numb Hs.509909 Numb NUMB homolog homolog (Drosophila) homolog (Drosophila), (NUMB), transcript variant (Drosophila) transcript variant 4, 4, mRNA Length = 3470 mRNA (cDNA clone MGC: 87117 IMAGE: 4822300), complete cds Length = 3509 236 BC012527.2 Homo sapiens NM_181054.1 Homo sapiens hypoxia- Hs.509554 Hypoxia- HIF1A hypoxia-inducible inducible factor 1, alpha inducible factor 1, alpha subunit (basic helix-loop- factor 1, subunit (basic helix- helix transcription factor) alpha subunit loop-helix (HIF1A), transcript variant (basic helix- transcription factor), 2, mRNA Length = 3812 loop-helix transcript variant 1, transcription mRNA (cDNA clone factor) MGC: 10483 IMAGE: 3842146), complete cds Length = 3933 237 AY851161.1 Homo sapiens decay NM_000574.2 Homo sapiens decay Hs.527653 Decay DAF accelerating factor accelerating factor for accelerating for complement complement (CD55, factor for (CD55, Cromer Cromer blood group complement blood group system) system) (DAF), mRNA (CD55, (DAF) gene, Length = 2308 Cromer complete cds blood group Length = 43741 system) 238 AY323826.1 Homo sapiens NM_000628.3 Homo sapiens interleukin Hs.418291 Interleukin IL10RB interleukin 10 10 receptor, beta (IL10RB), 10 receptor, receptor, beta mRNA Length = 1935 beta (IL10RB) gene, complete cds Length = 36210 239 AC061992.11 Homo sapiens Hs.464217 Dynein, PGS1 chromosome 17, axonemal, clone RP11-806H10, heavy complete sequence polypeptide Length = 100190 17 240 L21950.1 HUMBENZA Human NM_007311.3 Homo sapiens Hs.202 Benzodiazapine BZRP peripheral benzodiazapine receptor receptor benzodiazepine (peripheral) (BZRP), (peripheral) receptor related transcript variant PBR-S, mRNA sequence mRNA Length = 665 Length = 639 241 BC001110.2 Homo sapiens NM_000714.4 Homo sapiens Hs.202 Benzodiazapine BZRP benzodiazapine benzodiazapine receptor receptor receptor (peripheral), (peripheral) (BZRP), (peripheral) transcript variant transcript variant PBR, PBR, mRNA (cDNA mRNA Length = 876 clone MGC: 1184 IMAGE: 2989070), complete cds Length = 871 242 BC013008.2 Homo sapiens NM_002795.2 Homo sapiens proteasome Hs.550875 Transcribed proteasome (prosome, macropain) locus, (prosome, subunit, beta type, 3 strongly macropain) subunit, (PSMB3), mRNA similar to beta type, 3, mRNA Length = 784 NP_002786.2 (cDNA clone proteasome MGC: 4147 beta 3 IMAGE: 3010175), subunit; complete cds proteasome Length = 783 theta chain; proteasome chain 13; proteasome component C10-II [Homo sapiens] 243 AC025471.6 Homo sapiens NM_001737.2 Homo sapiens complement Hs.1290 Complement C9 chromosome 5 clone component 9 (C9), mRNA component 9 RP11-138C1, Length = 2094 complete sequence Length = 148607 244 BT019502.1 Homo sapiens bone NM_004334.1 Homo sapiens bone Hs.169998 Bone BST1 marrow stromal cell marrow stromal cell antigen marrow antigen 1 mRNA, 1 (BST1), mRNA stromal cell complete cds Length = 1411 antigen 1 Length = 957 245 BC013589.1 Homo sapiens NM_002468.2 Homo sapiens myeloid Hs.82116 Myeloid MYD88 myeloid differentiation primary differentiation differentiation response gene (88) primary primary response (MYD88), mRNA response gene (88), mRNA Length = 2678 gene (88) (cDNA clone MGC: 9601 IMAGE: 3900951), complete cds Length = 2678 246 BC013589.1 Homo sapiens NM_002468.2 Homo sapiens myeloid Hs.82116 Myeloid MYD88 myeloid differentiation primary differentiation differentiation response gene (88) primary primary response (MYD88), mRNA response gene (88), mRNA Length = 2678 gene (88) (cDNA clone MGC: 9601 IMAGE: 3900951), complete cds Length = 2678 247 AY279384.1 Homo sapiens NM_198829.1 Homo sapiens ras-related Hs.558376 Ras-related RAC1 migration-inducing C3 botulinum toxin C3 botulinum protein 5 (MIG5) substrate 1 (rho family, toxin mRNA, complete cds small GTP binding protein substrate 1 Length = 833 Rac1) (RAC1), transcript (rho family, variant Rac1c, mRNA small GTP Length = 2413 binding protein Rac1) 248 AC007655.1 Homo sapiens 12p13 NM_001175.4 Homo sapiens Rho GDP Hs.504877 Rho GDP ARHGDIB BAC RPCI11-233G1 dissociation inhibitor (GDI) dissociation (Roswell Park beta (ARHGDIB), mRNA inhibitor Cancer Institute Length = 1216 (GDI) beta Human BAC Library) complete sequence Length = 180069 249 BC001410.2 Homo sapiens S100 NM_005620.1 Homo sapiens S100 Hs.547382 CDNA clone calcium binding calcium binding protein A11 IMAGE: 30389268 protein A11 (calgizzarin) (S100A11), (calgizzarin), mRNA mRNA Length = 595 (cDNA clone MGC: 2149 IMAGE: 3140092), complete cds Length = 568 250 DQ214322.1 Taeniopygia guttata NM_002107.3 Homo sapiens H3 histone, Hs.546259 Similar to clone family 3A (H3F3A), mRNA Histone H3.3 0058P0025E11 H3 Length = 1117 histone family 3A-like mRNA, complete sequence Length = 1109 251 AF129756.1 DJ201G24 Homo NM_001288.4 Homo sapiens chloride Hs.414565 Chloride CLIC1 sapiens MSH55 intracellular channel 1 intracellular gene, partial cds; (CLIC1), mRNA channel 1 and CLIC1, DDAH, Length = 1265 G6b, G6c, G5b, G6d, G6e, G6f, BAT5, G5b, CSK2B, BAT4, G4, Apo M, BAT3, BAT2, AIF-1, 1C7, LST-1, LTB, TNF, and LTA genes, complete cds Length = 184666 252 M90727.1 HUMFCGRA07 NM_021642.2 Homo sapiens Fc fragment Hs.352642 Fc fragment FCGR2A Homo sapiens Fc- of IgG, low affinity IIa, of IgG, low gamma-receptor IIA receptor (CD32) affinity IIa, (FCGR2A) gene, (FCGR2A), mRNA receptor exon 8 Length = 1659 Length = 2411 (CD32) 253 M90727.1 HUMFCGRA07 NM_021642.2 Homo sapiens Fc fragment Hs.352642 Fc fragment FCGR2A Homo sapiens Fc- of IgG, low affinity IIa, of IgG, low gamma-receptor IIA receptor (CD32) affinity IIa, (FCGR2A) gene, (FCGR2A), mRNA receptor exon 8 Length = 1659 Length = 2411 (CD32) 254 U87575.1 HSU87575 Human NM_001002273.1 Homo sapiens Fc fragment Hs.492655 Fc fragment FCGR2B Fc-gamma-RIIb2 of IgG, low affinity IIb, of IgG, low (Fc-gamma-RIIB) receptor (CD32) affinity IIc, mRNA, partial cds (FCGR2B), transcript receptor for Length = 873 variant 2, mRNA (CD32) Length = 1573 255 AC108044.5 Homo sapiens BAC NM_006068.2 Homo sapiens toll-like Hs.366986 Toll-like TLR6 clone RP11-280E3 receptor 6 (TLR6), mRNA receptor 6 from 4, complete Length = 2753 sequence Length = 173834 256 AY651785.1 Homo sapiens NM_000634.2 Homo sapiens interleukin 8 Hs.194778 Interleukin 8 IL8RA interleukin 8 receptor, alpha (IL8RA), receptor, receptor, alpha mRNA Length = 2502 alpha (IL8RA) gene, complete cds Length = 19092 257 AY714242.1 Homo sapiens NM_001557.2 Homo sapiens interleukin 8 Hs.846 Interleukin 8 IL8RB interleukin 8 receptor, beta (IL8RB), receptor, receptor, beta mRNA Length = 2859 beta (IL8RB) gene, complete cds Length = 25733 258 AY771351.1 Homo sapiens zinc NM_003407.1 Homo sapiens zinc finger Hs.534052 Zinc finger ZFP36 finger protein 36, protein 36, C3H type, protein 36, C3H type, homolog homolog (mouse) (ZFP36), C3H type, (mouse) (ZFP36) mRNA Length = 1746 homolog gene, complete cds (mouse) Length = 5413 259 BC065293.1 Homo sapiens cDNA NM_004862.2 Homo sapiens Hs.459940 Lipopolysaccharide- LITAF clone lipopolysaccharide-induced induced TNF IMAGE: 6060454, TNF factor (LITAF), mRNA factor containing frame- Length = 2368 shift errors Length = 2238 260 BC010140.2 Homo sapiens tumor NM_001065.2 Homo sapiens tumor Hs.279594 Tumor TNFRSF1A necrosis factor necrosis factor receptor necrosis receptor superfamily, superfamily, member 1A factor member 1A, mRNA (TNFRSF1A), mRNA receptor (cDNA clone Length = 2236 superfamily, MGC: 19588 member 1A IMAGE: 4131360), complete cds Length = 2185 261 BC010140.2 Homo sapiens tumor NM_001065.2 Homo sapiens tumor Hs.279594 Tumor TNFRSF1A necrosis factor necrosis factor receptor necrosis receptor superfamily, superfamily, member 1A factor member 1A, mRNA (TNFRSF1A), mRNA receptor (cDNA clone Length = 2236 superfamily, MGC: 19588 member 1A IMAGE: 4131360), complete cds Length = 2185 262 BC001602.1 Homo sapiens NM_003879.3 Homo sapiens CASP8 and Hs.447489 Similar to IFITM3 CASP8 and FADD- FADD-like apoptosis Interferon- like apoptosis regulator (CFLAR), mRNA induced regulator, mRNA Length = 2243 transmembrane (cDNA clone protein 3 MGC: 2044 (Interferon- IMAGE: 3542993), inducible complete cds protein 1-8U) Length = 2025 263 BC001602.1 Homo sapiens NM_003879.3 Homo sapiens CASP8 and Hs.390736 CASP8 and CFLAR CASP8 and FADD- FADD-like apoptosis FADD-like like apoptosis regulator (CFLAR), mRNA apoptosis regulator, mRNA Length = 2243 regulator (cDNA clone MGC: 2044 IMAGE: 3542993), complete cds Length = 2025 264 AC005300.10 Homo sapiens NM_014339.3 Homo sapiens interleukin Hs.129751 Interleukin IL17R chromosome 22 17 receptor (IL17R), mRNA 17 receptor clone p143i13 map Length = 3429 22q11, complete sequence Length = 101269 265 BC014966.1 Homo sapiens NM_001006665.1 Homo sapiens ribosomal Hs.149957 Ribosomal RPS6KA1 ribosomal protein S6 protein S6 kinase, 90 kDa, protein S6 kinase, 90 kDa, polypeptide 1 (RPS6KA1), kinase, polypeptide 1, mRNA transcript variant 2, mRNA 90 kDa, (cDNA clone Length = 3112 polypeptide 1 MGC: 23062 IMAGE: 4867373), complete cds Length = 3206 266 BC029782.1 Homo sapiens NM_003006.3 Homo sapiens selectin P Hs.127346 Selectin P SELPLG selectin P ligand, ligand (SELPLG), mRNA ligand mRNA (cDNA clone Length = 2550 MGC: 34401 IMAGE: 5180824), complete cds Length = 2173 267 BC064500.1 Homosapiens NM_001109.2 Homo sapiens ADAM Hs.501574 ADAM ADAM8 ADAM metallopeptidase domain 8 metallopeptidase metallopeptidase (ADAM8), mRNA domain 8 domain 8, mRNA Length = 3275 (cDNA clone IMAGE: 6247789) Length = 3115 268 BC014117.2 Homo sapiens NM_030984.1 Homo sapiens Hs.520757 Thromboxane TBXAS1 thromboxane A thromboxane A synthase 1 A synthase synthase 1 (platelet, (platelet, cytochrome P450, 1 (platelet, cytochrome P450, family 5, subfamily A) cytochrome family 5, subfamily (TBXAS1), transcript P450, family A), mRNA (cDNA variant TXS-II, mRNA 5, subfamily clone MGC: 20885 Length = 1783 A) IMAGE: 4548935), complete cds Length = 2119 269 BC017412.1 Homo sapiens NM_006866.1 Homo sapiens leukocyte Hs.534394 Leukocyte LILRA2 leukocyte immunoglobulin-like immunoglobulin- immunoglobulin-like receptor, subfamily A (with like receptor, subfamily A TM domain), member 2 receptor, (with TM domain), (LILRA2), mRNA subfamily A member 2, mRNA Length = 1696 (with TM (cDNA clone domain), MGC: 27265 member 2 IMAGE: 4618777), complete cds Length = 1682 270 AY651785.1 Homo sapiens NM_000634.2 Homo sapiens interleukin 8 Hs.194778 Interleukin 8 IL8RA interleukin 8 receptor, alpha (IL8RA), receptor, receptor, alpha mRNA Length = 2502 alpha (IL8RA) gene, complete cds Length = 19092 271 BC011991.1 Homo sapiens serpin NM_001002236.1 Homo sapiens serpin Hs.525557 Serpin SERPINA1 peptidase inhibitor, peptidase inhibitor, clade A peptidase clade A (alpha-1 (alpha-1 antiproteinase, inhibitor, antiproteinase, antitrypsin), member 1 clade A antitrypsin), member (SERPINA1), transcript (alpha-1 1, transcript variant variant 2, mRNA antiproteinase, 1, mRNA (cDNA Length = 1902 antitrypsin), clone MGC: 9222 member 1 IMAGE: 3859644), complete cds Length = 1584 272 AF543826.1 Homo sapiens IgG NM_001002273.1 Homo sapiens Fc fragment Hs.492655 Fc fragment FCGR2B receptor IIB of IgG, low affinity IIb, of IgG, low (FCGR2B) mRNA, receptor (CD32) affinity IIc, complete cds (FCGR2B), transcript receptor for Length = 1509 variant 2, mRNA (CD32) Length = 1573 273 AC068657.6 Homo sapiens NM_000679.3 Homo sapiens adrenergic, Hs.368632 Adrenergic, ADRA1B chromosome 5 clone alpha-1B-, receptor alpha-1B-, CTB-67I13, complete (ADRA1B), mRNA receptor sequence Length = 2272 Length = 128332 274 AC004849.1 Homo sapiens PAC XM_376680.2 PREDICTED: Homo Hs.308710 KIAA1718 KIAA1718 clone RP4-659J6 sapiens KIAA1718 protein protein from 7, complete (KIAA1718), mRNA sequence Length = 9910 Length = 126801 275 BC066116.1 Homo sapiens NM_000478.2 Homo sapiens alkaline Hs.75431 Alkaline ALPL alkaline phosphatase, phosphatase, phosphatase, liver/bone/kidney (ALPL), liver/bone/kidney liver/bone/kidney, mRNA Length = 2580 mRNA (cDNA clone IMAGE: 5754297), partial cds Length = 2561 276 AC072022.19 Homo sapiens 3 NM_138931.1 Homo sapiens B-cell Hs.478588 B-cell BCL6 BAC RP11-211G3 CLL/lymphoma 6 (zinc CLL/lymphoma (Roswell Park finger protein 51) (BCL6), 6 (zinc Cancer Institute transcript variant 2, mRNA finger protein Human BAC Library) Length = 3630 51) complete sequence Length = 125395 277 J03925.1 HUMMAC1A Human NM_000632.2 Homo sapiens integrin, Hs.172631 Integrin, ITGAM Mac-1 gene alpha M (complement alpha M encoding component receptor 3, (complement complement receptor alpha; also known as component type 3, CD11b, CD11b (p170), receptor 3, complete cds macrophage antigen alpha alpha; also Length = 4740 polypeptide) (ITGAM), known as mRNA Length = 4740 CD11b (p170), macrophage antigen alpha polypeptide) 278 AY233976.1 Homo sapiens NM_000655.2 Homo sapiens selectin L Hs.82848 Selectin L SELL selectin L (lymphocyte adhesion (lymphocyte (lymphocyte molecule 1) (SELL), mRNA adhesion adhesion molecule Length = 2324 molecule 1) 1) (SELL) gene, complete cds Length = 24822 279 AC108044.5 Homo sapiens BAC NM_003263.3 Homo sapiens toll-like Hs.111805 Toll-like TLR1 clone RP11-280E3 receptor 1 (TLR1), mRNA receptor 1 from 4, complete Length = 2867 sequence Length = 173834 280 J03571.1 HUMLOX5A Human NM_000698.2 Homo sapiens Hs.89499 Arachidonate ALOX5 5-lipoxygenase arachidonate 5- 5- mRNA, complete cds lipoxygenase (ALOX5), lipoxygenase Length = 2484 mRNA Length = 2568 281 BC053585.1 Homo sapiens NM_172313.1 Homo sapiens colony Hs.524517 Colony CSF3R colony stimulating stimulating factor 3 stimulating factor 3 receptor receptor (granulocyte) factor 3 (granulocyte), (CSF3R), transcript variant receptor transcript variant 1, 4, mRNA Length = 2583 (granulocyte) mRNA (cDNA clone MGC: 61541 IMAGE: 5217305), complete cds Length = 3029 282 Hs.89499 Arachidonate ALOX5 5- lipoxygenase 283 AY358712.1 Homo sapiens clone NM_024308.2 Homo sapiens short-chain Hs.462859 Short-chain MGC4172 DNA77626 dehydrogenase/reductase dehydrogenase/ ARPG836 (UNQ836) (MGC4172), mRNA reductase mRNA, complete cds Length = 1501 Length = 1505 284 Hs.501853 TMEM9 C11orf15 domain family, member B 285 AC011241.7 Homo sapiens BAC Hs.146657 Transcribed clone RP11-467P13 locus from 2, complete sequence Length = 104891 286 AC093752.2 Homo sapiens BAC Hs.535008 Full length clone RP11-33B1 insert cDNA from 4, complete clone sequence YU26H08 Length = 130879 287 AF131806.1 AF131806 Homo Hs.494875 Regulator of RGS3 sapiens clone 24863 G-protein mRNA sequence signalling 3 Length = 1841 288 AC016735.10 Homo sapiens BAC clone RP11-391M15 from 2, complete sequence Length = 182730 289 AC013472.8 Homo sapiens BAC XM_515349.1 PREDICTED: Pan Hs.132725 Transcribed clone RP11-503P10 troglodytes LOC459090 locus, from 2, complete (LOC459090), mRNA strongly sequence Length = 1791 similar to Length = 149481 XP_515349.1 PREDICTED: hypothetical protein XP_515349 [Pan troglodytes] 290 BC073839.1 Homo sapiens tumor NM_152942.2 Homo sapiens tumor Hs.1314 Tumor TNFRSF8 necrosis factor necrosis factor receptor necrosis receptor superfamily, superfamily, member 8 factor member 8, mRNA (TNFRSF8), transcript receptor (cDNA clone variant 2, mRNA superfamily, IMAGE: 5219187), Length = 2361 member 8 partial cds Length = 2179 291 Hs.527684 Transcribed locus 292 BC073999.1 Homo sapiens NM_004121.1 Homo sapiens gamma- Hs.437156 Gamma- GGTLA1 gamma- glutamyltransferase-like glutamyltransferase- glutamyltransferase- activity 1 (GGTLA1), mRNA like like activity 1, mRNA Length = 2414 activity 1 (cDNA clone MGC: 87996 IMAGE: 6198113), complete cds Length = 2481 293 BC004490.2 Homo sapiens v-fos NM_005252.2 Homo sapiens v-fos FBJ Hs.25647 V-fos FBJ FOS FBJ murine murine osteosarcoma viral murine osteosarcoma viral oncogene homolog (FOS), osteosarcoma oncogene homolog, mRNA Length = 2084 viral mRNA (cDNA clone oncogene MGC: 11074 homolog IMAGE: 3688670), complete cds Length = 1814 294 BC099908.1 Homo sapiens E2F NM_001949.2 Homo sapiens E2F Hs.269408 E2F E2F3 transcription factor 3, transcription factor 3 transcription mRNA (cDNA clone (E2F3), mRNA factor 3 IMAGE: 30531209), Length = 4744 complete cds Length = 4128 295 S75476.1 PGK1 = phosphoglycerate NM_000291.2 Homo sapiens Hs.78771 Phosphoglycerate PGK1 kinase 1 {3 phosphoglycerate kinase 1 kinase 1 nuclease-sensitive (PGK1), mRNA region} [human, Length = 2338 Genomic, 3571 nt] Length = 3571 296 AC152891.2 Pan troglodytes NM_022977.1 Homo sapiens acyl-CoA Hs.268785 Acyl-CoA ACSL4 chromosome X clone synthetase long-chain synthetase RP43-038O03 map family member 4 (ACSL4), long-chain human ortholog transcript variant 2, mRNA family Xq23, complete Length = 5356 member 4 sequence Length = 197819 297 AC152891.2 Pan troglodytes NM_022977.1 Homo sapiens acyl-CoA Hs.268785 Acyl-CoA ACSL4 chromosome X clone synthetase long-chain synthetase RP43-038O03 map family member 4 (ACSL4), long-chain human ortholog transcript variant 2, mRNA family Xq23, complete Length = 5356 member 4 sequence Length = 197819 298 BC067779.1 Homo sapiens TRAF NM_004180.2 Homo sapiens TRAF family Hs.132257 TRAF family TANK family member- member-associated NFKB member- associated NFKB activator (TANK), transcript associated activator, mRNA variant 1, mRNA NFKB (cDNA clone Length = 2089 activator MGC: 87157 IMAGE: 5296558), complete cds Length = 2052 299 BC002461.2 Homo sapiens NM_004330.1 Homo sapiens Hs.283454 BCL2/adeno BNIP2 BCL2/adenovirus BCL2/adenovirus E1B virus E1B E1B 19 kDa 19 kDa interacting protein 2 19 kDa interacting protein 2, (BNIP2), mRNA interacting mRNA (cDNA clone Length = 2382 protein 2 MGC: 1529 IMAGE: 3343559), complete cds Length = 2409 300 M23492.1 HUMLCA35 Homo NM_080922.1 Homo sapiens protein Hs.192039 Protein PTPRC sapiens T200 tyrosine phosphatase, tyrosine leukocyte common receptor type, C (PTPRC), phosphatase, antigen precursor transcript variant 3, mRNA receptor (PTPRC) gene, exon Length = 4882 type, C 33 and partial cds Length = 1375 301 BC019816.2 Homo sapiens heat NM_153201.1 Homo sapiens heat shock Hs.535026 Similar to shock 70 kDa protein 70 kDa protein 8 (HSPA8), Heat shock 8, transcript variant transcript variant 2, mRNA cognate 71 kDa 1, mRNA (cDNA Length = 1817 protein clone MGC: 29929 IMAGE: 2899894), complete cds Length = 2250 302 AC116913.6 Homo sapiens NM_002755.2 Homo sapiens mitogen- Hs.145442 Mitogen- MAP2K1 chromosome 15, activated protein kinase activated clone CTD-3185P2, kinase 1 (MAP2K1), mRNA protein complete sequence Length = 2222 kinase Length = 152561 kinase 1 303 BC18569.2 Homo sapiens NM_005389.1 Homo sapiens protein-L- Hs.279257 Protein-L- PCMT1 protein-L- isoaspartate (D-aspartate) isoaspartate isoaspartate (D- O-methyltransferase (D-aspartate) aspartate) O- (PCMT1), mRNA O- methyltransferase, Length = 1599 methyltransferase mRNA (cDNA clone IMAGE: 3446814) Length = 1237 304 AC098587.5 Homo sapiens BAC NM_006206.3 Homo sapiens platelet- Hs.74615 Platelet- PDGFRA clone RP11-231C18 derived growth factor derived from 4, complete receptor, alpha polypeptide growth factor sequence (PDGFRA), mRNA receptor, Length = 132164 Length = 6405 alpha polypeptide 305 AY101192.1 Homo sapiens CD44 NM_001001392.1 Homo sapiens CD44 Hs.502328 CD44 CD44 antigen (CD44) antigen (homing function antigen mRNA, complete cds and Indian blood group (homing Length = 2292 system) (CD44), transcript function and variant 5, mRNA Indian blood Length = 3985 group system) 306 AF277315.6 Homo sapiens NM_003639.2 Homo sapiens inhibitor of Hs.559535 Transcribed chromosome X clone kappa light polypeptide locus, RP5-865E18, RP5- gene enhancer in B-cells, strongly 1087L19 map q28, kinase gamma (IKBKG), similar to complete sequence mRNA Length = 2121 NP_003630.1 Length = 147234 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [Homo sapiens] 307 BT019600.1 Synthetic construct NM_172088.1 Homo sapiens tumor Hs.54673 Tumor TNFSF13 Homo sapiens tumor necrosis factor (ligand) necrosis necrosis factor superfamily, member 13 factor (ligand) superfamily, (TNFSF13), transcript (ligand) member 13 mRNA, variant gamma, mRNA superfamily, partial cds Length = 2095 member 12 Length = 753 308 BC030815.1 Homo sapiens NM_181524.1 Homo sapiens Hs.191911 Nuclear NFIA phosphoinositide-3- phosphoinositide-3-kinase, factor I/A kinase, regulatory regulatory subunit 1 (p85 subunit 1 (p85 alpha) (PIK3R1), transcript alpha), transcript variant 3, mRNA variant 2, mRNA Length = 5823 (cDNA clone MGC: 22760 IMAGE: 4290954), complete cds Length = 2427 309 1240372 310 U39657.1 HSU39657 Human NM_031988.1 Homo sapiens mitogen- Hs.463978 Mitogen- MAP2K6 MAP kinase kinase 6 activated protein kinase activated (MKK6) mRNA, kinase 6 (MAP2K6), protein complete cds transcript variant 2, mRNA kinase Length = 2924 Length = 2820 kinase 6 311 IMAGE: 114030 312 AC073336.6 Homo sapiens BAC Hs.434944 Transcribed clone RP11-476H24 locus from 7, complete sequence Length = 166261 313 AC023818.5 Homo sapiens Hs.295923 Seven in SIAH1 chromosome 16 absentia clone CTD-2600H12, homolog 1 complete sequence (Drosophila) Length = 173304 314 AC005856.1 AC005856 Homo Hs.517949 Microtubule- MAP4 sapiens associated chromosome 17, protein 4 clone hRPK.136_H_19, complete sequence Length = 126910 315 AC005881.3 AC005881 Hs.567261 Single SSBP3 citb_79_e_16, stranded complete sequence DNA binding Length = 181773 protein 3 316 AC025423.32 Homo sapiens 12 NM_006878.2 Homo sapiens Mdm2, Hs.369849 Mdm2, MDM2 BAC RP11-611O2 transformed 3T3 cell transformed (Roswell Park double minute 2, p53 3T3 cell Cancer Institute binding protein (mouse) double Human BAC Library) (MDM2), transcript variant minute 2, complete sequence MDM2a, mRNA p53 binding Length = 150579 Length = 1613 protein (mouse) 317 Hs.127386 MAM domain MAMDC2 containing 2 318 Hs.293928 Hypothetical gene supported by AK024293 319 AC011092.4 Homo sapiens, clone Hs.438794 SET binding SBF2 RP11-1H15, factor 2 complete sequence Length = 192318 320 AY789109.1 Homo sapiens interleukin 3 receptor, alpha (low affinity) (IL3RA) gene, complete cds Length = 49973 321 AC007878.2 Homo sapiens BAC Hs.434401 Zinc finger ZNF638 clone RP11-236P2 protein 638 from 2, complete sequence Length = 185134 322 Hs.123070 Homeo box HOXD10 D10 323 AY162833.1 Homo sapiens E2F Hs.445758 E2F E2F5 transcription factor 5, transcription p130-binding (E2F5) factor 5, gene, complete cds p130-binding Length = 38504 324 AC084794.3 Homo sapiens Hs.547315 Hypothetical chromosome 16 protein clone CTA-154B9, LOC440345 complete sequence Length = 230510 325 AC005532.2 Homo sapiens PAC clone RP4-733B9 from 7, complete sequence Length = 115954 326 IMAGE: 2336269 327 Hs.513706 MARVEL MARVELD3 domain containing 3 328 Hs.22930 Transcribed locus 329 BC039424.1 Homo sapiens cDNA Hs.378808 Eukaryotic eIF2A clone translation IMAGE: 5302722 initiation Length = 1526 factor (eIF) 2A 330 AF377331.2 AF377331 Homo NM_002188.2 Homo sapiens interleukin Hs.845 Interleukin IL13 sapiens interleukin 13 (IL13), mRNA 13 13 (IL13) gene, Length = 1282 complete cds Length = 6919 331 Hs.147531 Transcribed locus 332 AC126283.3 Homo sapiens BAC NM_000204.1 Homo sapiens I factor Hs.312485 I factor IF clone RP11-602N24 (complement) (IF), mRNA (complement) from 4, complete Length = 1963 sequence Length = 118642 333 BC046362.1 Homo sapiens NM_183240.1 Homo sapiens Hs.26216 Transmembrane TMEM37 transmembrane transmembrane protein 37 protein protein 37, mRNA (TMEM37), mRNA 37 (cDNA clone Length = 579 MGC: 50757 IMAGE: 5221396), complete cds Length = 1850 334 AF313041.4 Homo sapiens Hs.336994 Metastasis MTSS1 chromosome 8 clone suppressor 1 RP11-158K1 map q24.13, complete sequence Length = 193882 335 Hs.159827 Transcribed locus 336 AC009265.10 Homo sapiens, clone Hs.558316 Chitobiase, CTBS RP11-45B18, di-N-acetyl- complete sequence Length = 179844 337 AY714878.1 Homo sapiens anti- NM_020547.1 Homo sapiens anti- Hs.437877 Anti- AMHR2 Mullerian hormone Mullerian hormone Mullerian receptor type II receptor, type II (AMHR2), hormone (AMHR2) mRNA, mRNA Length = 1855 receptor, complete cds, type II alternatively spliced Length = 1437 338 AF235103.5 Homo sapiens chromosome 8 multiple clones map q24.3, complete sequence Length = 345524 339 AY509906.1 Homo sapiens NM_018402.1 Homo sapiens interleukin Hs.272350 Interleukin IL26 interleukin 26 (IL26) 26 (IL26), mRNA 26 gene, complete cds Length = 1047 Length = 33991 340 Hs.148360 Transcribed locus 341 XM_499571 PREDICTED: Homo XM_499571 PREDICTED: Homo Hs.558664 PREDICTED: sapiens hypothetical sapiens hypothetical protein Homo sapiens protein FLJ30672 FLJ30672 (FLJ30672) hypothetical (FLJ30672), mRNA protein FLJ30672 (FLJ30672) 342 AC008870.8 Homo sapiens Hs.560464 Transcribed chromosome 16 locus clone CTD-2196E14, complete sequence Length = 150522 343 AC131097.6 Homo sapiens BAC Hs.372194 CDNA clone RP11-789L24 FLJ40615 from 2, complete fis, clone sequence THYMU2012882 Length = 187030 344 AC002395.1 Homo sapiens 12 Hs.76253 Ataxin 2 ATXN2 PAC RPCI1-315L5 (Roswell Park Cancer Institute Human PAC library) complete sequence Length = 155022 345 AC107909.5 Homo sapiens chromosome 8, clone CTD-2340D6, complete sequence Length = 149001 346 BC058922.1 Homo sapiens cDNA NM_001017402.1 Homo sapiens laminin, beta Hs.497636 Laminin, LAMB3 clone 3 (LAMB3), transcript beta 3 IMAGE: 5175186, variant 2, mRNA containing frame- Length = 4339 shift errors Length = 4119 347 AC124833.1 Homo sapiens BAC Hs.134634 Transcribed clone RP11-324E12 locus from 7, complete sequence Length = 80050 348 BC007032.1 Homo sapiens cDNA NM_000607.1 Homo sapiens Hs.522356 Orosomucoid 1 ORM1 clone orosomucoid 1 (ORM1), IMAGE: 4071534, mRNA Length = 803 containing frame- shift errors Length = 845 349 Hs.522520 Chromosome C9orf37 9 open reading frame 37 350 AB008193 Homo sapiens genes AB008193 Homo sapiens genes for Hs.567248 leukotriene LTB4R for leukotriene B4 leukotriene B4 receptor B4 receptor receptor BLT2, BLT2, leukotriene B4 BLT2, leukotriene B4 leukotriene B4 351 BC101754.1 Homo sapiens cDNA XM_514191.1 PREDICTED: Pan Hs.19281 Protein PTPN14 clone MGC: 126803 troglodytes similar to tyrosine IMAGE: 8069260, protein tyrosine phosphatase, complete cds phosphatase, non-receptor non- Length = 3645 type 14; cytoskeletal- receptor type associated protein tyrosine 14 phosphatase (LOC457730), mRNA Length = 3218 352 AC067881.5 Homo sapiens Hs.332422 Aspartate ASPH chromosome 8, beta- clone RP11-687K23, hydroxylase complete sequence Length = 186676 353 Hs.476706 Mitochondrial MRPL37 ribosomal protein L37 354 Hs.86080 Transcribed locus, moderately similar to NP_777603.1 hypothetical protein FLJ25976 [Homo sapiens] 355 BC034406.1 Homo sapiens NM_022141.4 Homo sapiens parvin, Hs.437857 Parvin, PARVG parvin, gamma, gamma (PARVG), mRNA gamma mRNA (cDNA clone Length = 1629 MGC: 35319 IMAGE: 5178529), complete cds Length = 1684 356 Hs.529643 Transcribed locus 357 BC034761.1 Homo sapiens NM_007264.3 Homo sapiens Hs.483909 Adrenomedullin ADMR adrenomedullin adrenomedullin receptor receptor receptor, mRNA (ADMR), mRNA (cDNA clone Length = 1620 MGC: 34399 IMAGE: 5185932), complete cds Length = 1745 358 IMAGE: 1713245 359 Hs.287537 B cell RAG GALNAC4S- associated 6ST protein 360 BC072681.1 Homo sapiens zinc NM_020205.1 Homo sapiens zinc finger, Hs.98322 Zinc finger, ZA20D1 finger, A20 domain A20 domain containing 1 A20 domain containing 1, mRNA (ZA20D1), mRNA containing 1 (cDNA clone Length = 3159 MGC: 87939 IMAGE: 6170513), complete cds Length = 3618 361 Hs.558924 FLJ42177 FLJ42177 protein 362 AC006531.1 AC006531 Homo Hs.411472 Glutamate GRIN2A sapiens receptor, chromosome 16 ionotropic, N- clone 113K5, methyl D- complete sequence aspartate 2A Length = 167525 363 AC019227.4 Homo sapiens BAC Hs.178499 CDNA clone RP11-567O18 FLJ39357 from 11, complete fis, clone sequence PEBLM2003914 Length = 190314 364 AC055711.18 Homo sapiens 3 BAC RP11-67E18 (Roswell Park Cancer Institute Human BAC Library) complete sequence Length = 154850 365 BC074964.2 Homo sapiens ciliary NM_170768.1 Homo sapiens zinc finger Hs.524920 Zinc finger ZFP91 neurotrophic factor, protein 91 homolog protein 91 mRNA (cDNA clone (mouse) (ZFP91), transcript homolog MGC: 103900 variant 2, mRNA (mouse) IMAGE: 30915287), Length = 3478 complete cds Length = 665 366 AC091974.3 Homo sapiens Hs.444390 Homo chromosome 5 clone sapiens, RP11-51P10, clone complete sequence IMAGE: 4479080 Length = 130853 367 AC010412.9 Homo sapiens NM_003573.1 Homo sapiens latent Hs.466766 Latent LTBP4 chromosome 19 transforming growth factor transforming clone CTD-2166J9, beta binding protein 4 growth factor complete sequence (LTBP4), mRNA beta binding Length = 155085 Length = 5054 protein 4 368 BC022283.1 Homo sapiens NM_005666.2 Homo sapiens complement Hs.154224 Complement CFHL1 complement factor factor H-related 2 (CFHL2), factor H- H-related 2, mRNA mRNA Length = 1043 related 1 (cDNA clone pseudogene MGC: 22434 IMAGE: 4734331), complete cds Length = 1075 369 BC015663.2 Homo sapiens serpin NM_006216.2 Homo sapiens serpin Hs.38449 Serpin SERPINE2 peptidase inhibitor, peptidase inhibitor, clade E peptidase clade E (nexin, (nexin, plasminogen inhibitor, plasminogen activator inhibitor type 1), clade E activator inhibitor member 2 (SERPINE2), (nexin, type 1), member 2, mRNA Length = 2120 plasminogen mRNA (cDNA clone activator MGC: 23129 inhibitor type IMAGE: 4578406), 1), member 2 complete cds Length = 2120 370 IMAGE: 2329442 371 AC002395.1 Homo sapiens 12 Hs.76253 Ataxin 2 ATXN2 PAC RPCI1-315L5 (Roswell Park Cancer Institute Human PAC library) complete sequence Length = 155022 372 AC026975.5 Homo sapiens NM_002843.2 Homo sapiens protein Hs.318547 Protein PTPRJ chromosome 11, tyrosine phosphatase, tyrosine clone RP11-709C9, receptor type, J (PTPRJ), phosphatase, complete sequence mRNA Length = 5119 receptor Length = 200105 type, J 373 BC041943.1 Homo sapiens Hs.479954 Methylenetetrahydrofolate MTHFD2L methylenetetrahydrofolate dehydrogenase dehydrogenase (NADP+ (NADP+ dependent) dependent) 2-like, mRNA (cDNA 2-like clone IMAGE: 5301277) Length = 2377 374 AC007653.5 AC007653 Homo Hs.478393 Peroxisomal PEX5L sapiens biogenesis chromosome, clone factor 5-like RP11-51A1, complete sequence Length = 159926 375 AC026250.16 Homo sapiens Hs.552269 MRNA; chromosome 11, cDNA clone RP11-540A21, DKFZp686C19106 complete sequence (from Length = 160681 clone DKFZp686C19106) 376 Hs.190342 Transcribed locus 377 BC068537.1 Homo sapiens serine NM_006415.2 Homo sapiens serine Hs.124503 Serine TCF8 palmitoyltransferase, palmitoyltransferase, long palmitoyltransferase, long chain base chain base subunit 1 long subunit 1, mRNA (SPTLC1), transcript chain base (cDNA clone variant 1, mRNA subunit 1 MGC: 87384 Length = 2780 IMAGE: 5259635), complete cds Length = 2742 378 BC063588.1 Homo sapiens NM_201274.2 Homo sapiens myosin Hs.462341 Myosin M-RIP myosin phosphatase- phosphatase-Rho phosphatase- Rho interacting interacting protein (M-RIP), Rho protein, mRNA mRNA Length = 3923 interacting (cDNA clone protein IMAGE: 4441347), partial cds Length = 2072 379 AY779023.1 Homo sapiens NM_181310.1 Homo sapiens interleukin Hs.126891 Interleukin IL22RA2 interleukin 22 22 receptor, alpha 2 22 receptor, receptor, alpha 2 (IL22RA2), transcript alpha 2 (IL22RA2) gene, variant 3, mRNA complete cds Length = 2644 Length = 32866 380 AC008770.7 Homo sapiens chromosome 19 clone CTD-2006C1, complete sequence Length = 178184 381 AC011452.6 AC011452 Homo NM_012068.2 Homo sapiens activating Hs.9754 Activating ATF5 sapiens transcription factor 5 transcription chromosome 19 (ATF5), mRNA factor 5 clone CTC-326K19, Length = 2010 complete sequence Length = 146741 382 AC117395.5 Homo sapiens 3 Hs.12333 Ring finger RNF13 BAC RP11-651P23 protein 13 (Roswell Park Cancer Institute Human BAC Library) complete sequence Length = 172715 383 Hs.562136 Transcribed locus 384 BC033989.2 Homo sapiens cDNA Hs.369473 CDNA clone clone IMAGE: 5296164 IMAGE: 5296164 Length = 911 385 AF220188.1 AF220188 Homo Hs.479766 TPA TPARL sapiens regulated uncharacterized locus hypothalamus protein HTMP mRNA, complete cds Length = 1913 386 AY603772.1 Homo sapiens UDP NG_002601.1 Homo sapiens UDP Hs.554822 UDP UGT1A6 glycosyltransferase 1 glucuronosyltransferase 1 glucuronosyltransferase 1 family, polypeptide family, polypeptide A family, A1 (UGT1A1) gene, cluster (UGT1A@) on polypeptide complete cds chromosome 2 A9 Length = 16944 Length = 189056 387 BC067511.1 Homo sapiens NM_016584.2 Homo sapiens interleukin Hs.98309 Interleukin IL23A interleukin 23, alpha 23, alpha subunit p19 23, alpha subunit p19, mRNA (IL23A), mRNA subunit p19 (cDNA clone Length = 1049 MGC: 79390 IMAGE: 6971850), complete cds Length = 618 388 AF305083.1 AF305083 Homo NM_002033.2 Homo sapiens Hs.568106 Transcribed sapiens alpha(1,3)- fucosyltransferase 4 (alpha locus fucosyltransferase IV (1,3) fucosyltransferase, (FUTIV) gene, 3 myeloid-specific) (FUT4), UTR Length = 4192 mRNA Length = 5937 389 K01500.1 HUMA1ACM Human NM_001085.4 Homo sapiens serpin Hs.534293 Serpin SERPINA3 alpha-1- peptidase inhibitor, clade A peptidase antichymotrypsin (alpha-1 antiproteinase, inhibitor, (AACT) mRNA, antitrypsin), member 3 clade A complete cds (SERPINA3), mRNA (alpha-1 Length = 1520 Length = 1629 antiproteinase, antitrypsin), member 3 390 BC027933.1 Homo sapiens NM_002751.5 Homo sapiens mitogen- Hs.57732 Mitogen- MAPK11 mitogen-activated activated protein kinase 11 activated protein kinase 11, (MAPK11), transcript protein transcript variant 1, variant 1, mRNA kinase 11 mRNA (cDNA clone Length = 2420 MGC: 34566 IMAGE: 5199628), complete cds Length = 2480 391 Hs.562012 Transcribed locus 392 BC027933.1 Homo sapiens NM_002751.5 Homo sapiens mitogen- Hs.57732 Mitogen- MAPK11 mitogen-activated activated protein kinase 11 activated protein kinase 11, (MAPK11), transcript protein transcript variant 1, variant 1, mRNA kinase 11 mRNA (cDNA clone Length = 2420 MGC: 34566 IMAGE: 5199628), complete cds Length = 2480 393 AF284095.1 AF284095 Homo NM_000681.2 Homo sapiens adrenergic, Hs.249159 Adrenergic, ADRA2A sapiens alpha-2A alpha-2A-, receptor alpha-2A-, adrenergic receptor (ADRA2A), mRNA receptor mRNA, complete cds Length = 3653 Length = 3653 394 BC033694.1 Homo sapiens NM_006538.2 Homo sapiens BCL2-like Hs.469658 BCL2-like 11 BCL2L11 BCL2-like 11 11 (apoptosis facilitator) (apoptosis (apoptosis (BCL2L11), transcript facilitator) facilitator), transcript variant 6, mRNA variant 1, mRNA Length = 3242 (cDNA clone MGC: 45206 IMAGE: 5213713), complete cds Length = 3679 395 AC104850.2 Homo sapiens NM_005201.2 Homo sapiens chemokine Hs.113222 Chemokine CCR8 chromosome 3 clone (C-C motif) receptor 8 (C-C motif) RP11-241K18, (CCR8), mRNA receptor 8 complete sequence Length = 2370 Length = 173580 396 Hs.6874 Receptor RIPK5 interacting protein kinase 5 397 XM_514542.1 PREDICTED: Pan Hs.176013 Chromosome C20orf26 troglodytes similar to 20 open hypothetical protein reading (LOC458126), mRNA frame 26 Length = 3904 398 AC026458.8 Homo sapiens Hs.512856 SEC14-like 5 KIAA0420 chromosome 16 (S. cerevisiae) clone RP11-10K17, complete sequence Length = 153873 399 BC030514.1 Homo sapiens tudor XM_509806.1 PREDICTED: Pan Hs.525061 Tudor TDRD3 domain containing 3, troglodytes similar to tudor domain mRNA (cDNA clone domain containing 3 containing 3 MGC: 40253 (LOC452750), mRNA IMAGE: 4998330), Length = 2260 complete cds Length = 2550 400 AC015604.5 AC015604 Homo Hs.97313 Transcribed sapiens, clone RP11- locus 45D18, complete sequence Length = 172914 401 BC033094.1 Homo sapiens NM_003640.2 Homo sapiens inhibitor of Hs.494738 Inhibitor of IKBKAP inhibitor of kappa kappa light polypeptide kappa light light polypeptide gene enhancer in B-cells, polypeptide gene enhancer in B- kinase complex-associated gene cells, kinase protein (IKBKAP), mRNA enhancer in complex-associated Length = 5917 B-cells, protein, mRNA kinase (cDNA clone complex- MGC: 45667 associated IMAGE: 4562340), protein complete cds Length = 5047 402 Hs.485489 Chloride CLIC5 intracellular channel 5 403 BC005168.1 Homo sapiens NM_032646.5 Homo sapiens tweety Hs.27935 Tweety TTYH2 tweety homolog 2 homolog 2 (Drosophila) homolog 2 (Drosophila), mRNA (TTYH2), transcript variant (Drosophila) (cDNA clone 1, mRNA Length = 3468 IMAGE: 3543080), partial cds Length = 1775 404 BC040503.1 Homo sapiens NM_152332.2 Homo sapiens membrane Hs.510262 Membrane MTAC2D1 membrane targeting targeting (tandem) C2 targeting (tandem) C2 domain domain containing 1 (tandem) C2 containing 1, mRNA (MTAC2D1), mRNA domain (cDNA clone Length = 4620 containing 1 MGC: 33891 IMAGE: 5298787), complete cds Length = 4620 405 AC012307.8 Homo sapiens BAC NM_017849.1 Homo sapiens hypothetical Hs.355708 Hypothetical FLJ20507 clone RP11-574O17 protein FLJ20507 protein from 2, complete (FLJ20507), mRNA FLJ20507 sequence Length = 4223 Length = 145918 406 AC010542.7 Homo sapiens Hs.560416 Transcribed chromosome 16 locus clone RP11-403P17, complete sequence Length = 188460 407 Hs.370100 Chromosome CXorf26 X open reading frame 26 408 AC004080.2 Homo sapiens PAC Hs.414467 Homeo box HOXA13 clone RP1-170O19 A13 from 7p15-p21, complete sequence Length = 129355 409 Hs.470943 Signal STAT1 transducer and activator of transcription 1, 91 kDa 410 AC091529.1 AC091529 Homo Hs.445574 Full-length sapiens cDNA clone chromosome 17 CS0DK005YO12 clone 1005, of HeLa complete sequence cells Cot 25- Length = 157463 normalized of Homo sapiens (human) 411 XM_374767.1 PREDICTED: Homo Hs.146539 Hypothetical DKFZp667F0711 sapiens hypothetical protein protein DKFZp667F0711 DKFZp667F0711 (DKFZp667F0711), mRNA Length = 2447 412 BC052667.1 Mus musculus NM_008110.1 Mus musculus growth Mm.9714 Growth Gdf9 growth differentiation differentiation factor 9 differentiation factor 9, mRNA (Gdf9), mRNA factor 9 (cDNA clone Length = 1712 (Gdf9), MGC: 60651 mRNA IMAGE: 30054181), complete cds Length = 1752 413 BC051316.1 Homo sapiens NM_018029.3 Homo sapiens hypothetical Hs.534462 Hypothetical FLJ10213 hypothetical protein protein FLJ10213 protein FLJ10213, mRNA (FLJ10213), mRNA FLJ10213 (cDNA clone Length = 1679 IMAGE: 6214587) Length = 1679 414 BC033026.1 Homo sapiens NM_024899.2 Homo sapiens Hs.236940 Chromosome C18orf9 chromosome 18 chromosome 18 open 18 open open reading frame reading frame 9 (C18orf9), reading 9, mRNA (cDNA mRNA Length = 2884 frame 9 clone IMAGE: 5267551) Length = 2267 415 AC105206.8 Homo sapiens Hs.491223 Retinoic acid RAI16 chromosome 8, induced 16 clone CTD-2530N21, complete sequence Length = 218931 416 AC111196.4 Homo sapiens BAC Hs.128199 Septin 11 Sep 11 clone RP11-585K17 from 4, complete sequence Length = 35191 417 BC070091.1 Homo sapiens NM_052813.2 Homo sapiens caspase Hs.558530 Caspase CARD9 caspase recruitment recruitment domain family, recruitment domain family, member 9 (CARD9), domain member 9, mRNA mRNA Length = 2136 family, (cDNA clone member 9 MGC: 87491 IMAGE: 30343821), complete cds Length = 4078 418 AC118535.1 Homo sapiens Hs.408456 Protein PTPRS chromosome 19 tyrosine clone LLNLR-287H1, phosphatase, complete sequence receptor Length = 32887 type, S 419 BC107044.1 Homo sapiens cDNA NM_138294.2 Homo sapiens expressed Hs.148565 Expressed in PATE clone MGC: 129554 in prostate and testis prostate and IMAGE: 40002653, (PATE), mRNA testis complete cds Length = 1576 Length = 465 420 BC047698.1 Homo sapiens NM_000880.2 Homo sapiens interleukin 7 Hs.536926 Interleukin 7 IL7 interleukin 7, mRNA (IL7), mRNA Length = 2116 (cDNA clone MGC: 51943 IMAGE: 5748841), complete cds Length = 2125 421 AC108451.9 Homo sapiens Hs.459070 Aryl- ARNT2 chromosome 15, hydrocarbon clone RP11-379K22, receptor complete sequence nuclear Length = 198707 translocator 2 422 BC077726.1 Homo sapiens sema NM_001031702.1 Homo sapiens sema Hs.210870 Sema SEMA5B domain, seven domain, seven domain, thrombospondin thrombospondin repeats seven repeats (type 1 and (type 1 and type 1-like), thrombospondin type 1-like), transmembrane domain repeats transmembrane (TM) and short cytoplasmic (type 1 and domain (TM) and domain, (semaphorin) 5B type 1-like), short cytoplasmic (SEMA5B), transcript transmembrane domain, variant 1, mRNA domain (semaphorin) 5B, Length = 4494 (TM) and transcript variant 1, short mRNA (cDNA clone cytoplasmic MGC: 78583 domain, IMAGE: 6597493), (semaphorin) complete cds 5B Length = 4494 423 BC027920.1 Homo sapiens, clone NM_002348.2 Homo sapiens lymphocyte Hs.403857 Lymphocyte LY9 IMAGE: 5225850, antigen 9 (LY9), transcript antigen 9 mRNA Length = 2131 variant 1, mRNA Length = 2486 424 AF207550.3 Homo sapiens NM_017602.2 Homo sapiens hypothetical Hs.496098 OTU domain DKFZp761A052 chromosome X protein DKFZp761A052 containing 5 multiple clones map (DKFZp761A052), mRNA p11.23, complete Length = 2759 sequence Length = 128713 425 BC010284.1 Homo sapiens NM_004109.3 Homo sapiens ferredoxin 1 Hs.744 Ferredoxin 1 FDX1 ferredoxin 1, mRNA (FDX1), nuclear gene (cDNA clone encoding mitochondrial MGC: 5249 protein, mRNA IMAGE: 3048743), Length = 3236 complete cds Length = 3138 426 Hs.517717 Special AT- SATB1 rich sequence binding protein 1 (binds to nuclear matrix/scaffold- associating DNA's) 427 S49852.1 plasma membrane NM_001001323.1 Homo sapiens ATPase, Hs.506276 ATPase, ATP2B1 Ca2+ pump isoform Ca++ transporting, plasma Ca++ 1a {alternatively membrane 1 (ATP2B1), transporting, spliced} [human, transcript variant 1, mRNA plasma fetal brain, mRNA Length = 6950 membrane 1 Partial, 769 nt] Length = 769 428 BC020063.1 Homo sapiens CD84 NM_003874.1 Homo sapiens CD84 Hs.398093 CD84 CD84 antigen (leukocyte antigen (leukocyte antigen) antigen antigen), mRNA (CD84), mRNA (leukocyte (cDNA clone Length = 3299 antigen) MGC: 21324 IMAGE: 4385965), complete cds Length = 3278 429 AY162833.1 Homo sapiens E2F NM_001951.2 Homo sapiens E2F Hs.445758 E2F E2F5 transcription factor 5, transcription factor 5, p130- transcription p130-binding (E2F5) binding (E2F5), mRNA factor 5, gene, complete cds Length = 1752 p130-binding Length = 38504 430 BC050585.1 Homo sapiens NM_000210.1 Homo sapiens integrin, Hs.133397 Integrin, ITGA6 integrin, alpha 6, alpha 6 (ITGA6), mRNA alpha 6 mRNA (cDNA clone Length = 5611 IMAGE: 6150124), partial cds Length = 4267 431 BC007721.2 Homo sapiens DNA NM_213566.1 Homo sapiens DNA Hs.484782 DNA DFFA fragmentation factor, fragmentation factor, fragmentation 45 kDa, alpha 45 kDa, alpha polypeptide factor, polypeptide, (DFFA), transcript variant 2, 45 kDa, alpha transcript variant 1, mRNA Length = 3408 polypeptide mRNA (cDNA clone MGC: 12704 IMAGE: 4299734), complete cds Length = 1985 432 AC146440.5 Pan troglodytes BAC NM_033015.2 Homo sapiens Fas- Hs.75087 Fas- FASTK clone RP43-11P11 activated serine/threonine activated from 7, complete kinase (FASTK), transcript serine/threonine sequence variant 4, mRNA kinase Length = 181369 Length = 1443 433 NM_007177 family with sequence NM_007177 family with sequence Hs.8022 family with similarity 107, similarity 107, member A sequence member A similarity 107, member A 434 Hs.126573 Transcribed locus 435 BC019903.1 Homo sapiens XM_519249.1 PREDICTED: Pan Hs.369867 Hypothetical MGC40499 hypothetical protein troglodytes similar to protein MGC40499, mRNA hypothetical protein MGC40499 (cDNA clone MGC40499 (LOC463589), IMAGE: 4991480), mRNA Length = 1122 partial cds Length = 1413 436 Hs.304233 Similar to MGC52970 protein 437 BC004192.2 Homo sapiens NM_014754.1 Homo sapiens Hs.292579 Phosphatidylserine PTDSS1 phosphatidylserine phosphatidylserine synthase 1 synthase 1, mRNA synthase 1 (PTDSS1), (cDNA clone mRNA Length = 2504 MGC: 3305 IMAGE: 3509418), complete cds Length = 2528 438 BC015519.2 Homo sapiens NM_004708.2 Homo sapiens Hs.504942 Transcribed programmed cell programmed cell death 5 locus, death 5, mRNA (PDCD5), mRNA strongly (cDNA clone Length = 599 similar to MGC: 9294 XP_512563.1 IMAGE: 3888459), PREDICTED: complete cds similar to Length = 590 programmed cell death 5; TFAR19 novel apoptosis- related gene; TF1 cell apoptosis- related gene 19 [Pan troglodytes] 439 BC024034.2 Homo sapiens heat NM_004134.4 Homo sapiens heat shock Hs.560739 Heat shock HSPA9B shock 70 kDa protein 70 kDa protein 9B (mortalin- 70 kDa 9B (mortalin-2), 2) (HSPA9B), nuclear gene protein 9B mRNA (cDNA clone encoding mitochondrial (mortalin-2) MGC: 4500 protein, mRNA IMAGE: 2964588), Length = 2883 complete cds Length = 2802 440 BC016288.1 Homo sapiens NM_002013.2 Homo sapiens FK506 Hs.509226 FK506 FKBP3 FK506 binding binding protein 3, 25 kDa binding protein 3, 25 kDa, (FKBP3), mRNA protein 3, mRNA (cDNA clone Length = 1420 25 kDa MGC: 9482 IMAGE: 3919642), complete cds Length = 1420 441 BC023616.2 Homo sapiens NM_024026.4 Homo sapiens Hs.458367 Mitochondrial MRP63 mitochondrial mitochondrial ribosomal ribosomal ribosomal protein 63, protein 63 (MRP63), protein 63 mRNA (cDNA clone nuclear gene encoding MGC: 23340 mitochondrial protein, IMAGE: 4645641), mRNA Length = 2671 complete cds Length = 1160 442 AC008649.8 Homo sapiens NM_000540.1 Homo sapiens ryanodine Hs.466664 Ryanodine RYR1 chromosome 19 receptor 1 (skeletal) receptor 1 clone CTB-186G2, (RYR1), mRNA (skeletal) complete sequence Length = 15359 Length = 126682 443 Hs.444414 AF4/FMR2 LAF4 family, member 3 444 BC001169.1 Homo sapiens NM_001984.1 Homo sapiens esterase Hs.432491 Esterase ESD esterase D/formylglutathione D/formylglutathione D/formylglutathione hydrolase (ESD), mRNA hydrolase hydrolase, mRNA Length = 1208 (cDNA clone MGC: 1873 IMAGE: 3528593), complete cds Length = 1032 445 Hs.309763 G-rich RNA GRSF1 sequence binding factor 1 446 U66464.1 HSU66464 Human NM_007181.3 Homo sapiens mitogen- Hs.95424 Mitogen- MAP4K1 hematopoietic activated protein kinase activated progenitor kinase kinase kinase kinase 1 protein (HPK1) mRNA, (MAP4K1), mRNA kinase complete cds Length = 2732 kinase Length = 2732 kinase kinase 1 447 AC025457.5 AC025457 Homo NM_019846.3 Homo sapiens chemokine Hs.334633 Chemokine CCL28 sapiens (C-C motif) ligand 28 (C-C motif) chromosome 5 clone (CCL28), transcript variant ligand 28 CTD-2202K16, 1, mRNA Length = 1349 complete sequence Length = 140734 448 BC009401.2 Homo sapiens NM_001012636.1 Homo sapiens interleukin Hs.943 Interleukin NK4 interleukin 32, mRNA 32 (IL32), transcript variant 32 (cDNA clone 7, mRNA Length = 880 MGC: 15353 IMAGE: 4300407), complete cds Length = 1159 449 AC013274.6 Homo sapiens BAC Hs.413434 Solute carrier SLC39A10 clone RP11-449J2 family 39 from 2, complete (zinc sequence transporter), Length = 125133 member 10 450 Hs.516807 Serine/threonine STK25 kinase 25 (STE20 homolog, yeast) 451 AF034970.1 AF034970 Homo NM_003974.2 Homo sapiens docking Hs.71215 Docking DOK2 sapiens docking protein 2, 56 kDa (DOK2), protein 2, protein (DOK-2) transcript variant 1, mRNA 56 kDa mRNA, complete cds Length = 1870 Length = 1239 452 BC034403.1 Homo sapiens NM_001504.1 Homo sapiens chemokine Hs.198252 Chemokine CXCR3 chemokine (C—X—C (C—X—C motif) receptor 3 (C—X—C motif) motif) receptor 3, (CXCR3), mRNA receptor 3 mRNA (cDNA clone Length = 1670 MGC: 34593 IMAGE: 5176136), complete cds Length = 1626 453 Hs.525015 Transcribed locus, moderately similar to NP_005496.3 scavenger receptor class B, member 1; CD36 antigen-like 1; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; scavenger receptor class B type 1; scavenger receptor class B type III 454 AC023670.6 Homo sapiens BAC NG_002811.1 Homo sapiens glycogenin 2 Hs.541209 Glycogenin 2 GYG2 clone RP11-457M7 pseudogene (GYG2P) on from Xq23, complete chromosome Y sequence Length = 15111 Length = 59565 455 BC010856.2 Homo sapiens NM_001014842.1 Homo sapiens Hs.91586 Transmembrane 9 TM9SF1 transmembrane 9 transmembrane 9 superfamily superfamily member superfamily member 1 member 1 1, transcript variant (TM9SF1), transcript 1, mRNA (cDNA variant 2, mRNA clone MGC: 9160 Length = 2124 IMAGE: 3899246), complete cds Length = 2121 456 BC038289.1 Homo sapiens NM_032962.2 Homo sapiens chemokine Hs.272493 Chemokine CCL15 chemokine (C-C (C-C motif) ligand 14 (C-C motif) motif) ligand 14, (CCL14), transcript variant ligand 15 transcript variant 3, 2, mRNA Length = 1392 mRNA (cDNA clone MGC: 47546 IMAGE: 5222914), complete cds Length = 533 457 U19261.1 HSU19261 Homo Hs.531251 TNF TRAF1 sapiens Epstein-Barr receptor- virus-induced protein associated mRNA, complete cds factor 1 Length = 2380 458 BC000635.2 Homo sapiens NM_001607.2 Homo sapiens acetyl- Hs.166160 Acetyl- ACAA1 acetyl-Coenzyme A Coenzyme A Coenzyme A acyltransferase 1 acyltransferase 1 acyltransferase 1 (peroxisomal 3- (peroxisomal 3-oxoacyl- (peroxisomal oxoacyl-Coenzyme A Coenzyme A thiolase) 3-oxoacyl- thiolase), mRNA (ACAA1), nuclear gene Coenzyme A (cDNA clone encoding mitochondrial thiolase) MGC: 1165 protein, mRNA IMAGE: 3345271), Length = 1695 complete cds Length = 1720 459 BC027968.1 Homo sapiens NM_006274.2 Homo sapiens chemokine Hs.50002 Chemokine CCL19 chemokine (C-C (C-C motif) ligand 19 (C-C motif) motif) ligand 19, (CCL19), mRNA ligand 19 mRNA (cDNA clone Length = 684 MGC: 34433 IMAGE: 5225849), complete cds Length = 694 460 BC067735.1 Homo sapiens cDNA Hs.106432 Hypothetical DKFZp761B107 clone MGC: 86968 protein IMAGE: 4792861, DKFZp761B107 complete cds Length = 1096 461 AC016939.8 Homo sapiens X NM_005365.4 Homo sapiens melanoma Hs.512582 Melanoma MAGEA9 BAC RP5-1014O16 antigen family A, 9 antigen (Roswell Park (MAGEA9), mRNA family A, 9 Cancer Institute Length = 1824 Human BAC Library) complete sequence Length = 118440 462 Hs.567676 Transcribed locus, strongly similar to XP_509380.1 PREDICTED: similar to fertilin alpha- I [Pan troglodytes] 463 AC017104.8 Homo sapiens BAC Hs.470765 Zinc finger ARCH clone RP11-562I5 and BTB from 2, complete domain sequence containing 8 Length = 168880 opposite strand 464 BC070309.1 Homo sapiens NM_003175.2 Homo sapiens chemokine Hs.546295 Chemokine XCL1 chemokine (C motif) (C motif) ligand 2 (XCL2), (C motif) ligand 1, mRNA mRNA Length = 552 ligand 1 (cDNA clone MGC: 88311 IMAGE: 30416260), complete cds Length = 597 465 BC003582.1 Homo sapiens NM_021974.2 Homo sapiens polymerase Hs.436578 Polymerase POLR2F polymerase (RNA) II (RNA) II (DNA directed) (RNA) II (DNA directed) polypeptide F (POLR2F), (DNA polypeptide F, mRNA mRNA Length = 546 directed) (cDNA clone polypeptide F MGC: 2669 IMAGE: 3546712), complete cds Length = 588 466 IMAGE: 2317044 467 BT019901.1 Homo sapiens tumor NM_001250.3 Homo sapiens CD40 Hs.472860 CD40 CD40 necrosis factor antigen (TNF receptor antigen (TNF receptor superfamily, superfamily member 5) receptor member 5 mRNA, (CD40), transcript variant 1, superfamily complete cds mRNA Length = 1177 member 5) Length = 834 468 BC012160.1 Homo sapiens tumor NM_001242.3 Homo sapiens tumor Hs.355307 Tumor TNFRSF7 necrosis factor necrosis factor receptor necrosis receptor superfamily, superfamily, member 7 factor member 7, mRNA (TNFRSF7), mRNA receptor (cDNA clone Length = 1323 superfamily, MGC: 20393 member 7 IMAGE: 4575359), complete cds Length = 1323 469 BC067226.1 Homo sapiens NG_000834.1 Homo sapiens Hs.560836 Ig kappa immunoglobulin immunoglobulin kappa {clone kappa constant, locus, proximal V-cluster cYF.kappa} mRNA (cDNA clone and J-C cluster (IGK- [human, MGC: 72070 proximal) on chromosome mRNA IMAGE: 30349629), 2 Length = 515442 Features Partial, 1209 complete cds in this part of subject nt] Length = 969 sequence: CDS 470 BC018761.1 Homo sapiens cDNA XM_515609.1 PREDICTED: Pan Hs.551722 Ig clone troglodytes similar to rearranged IMAGE: 4565991 [Human Ig rearranged kappa-chain Length = 944 gamma chain mRNA, V-J- mRNA V-J1- C region and complete region, cds.], gene product hybridoma (LOC459391), mRNA AE6-5,5′ Length = 1867 end 471 AC099334.2 Homo sapiens NM_003243.2 Homo sapiens transforming Hs.482390 Transforming TGFBR3 chromosome 1 clone growth factor, beta receptor growth RP5-865M20, III (betaglycan, 300 kDa) factor, beta complete sequence (TGFBR3), mRNA receptor III Length = 112562 Length = 4199 (betaglycan, 300 kDa) 472 BC047695.1 Homo sapiens NM_005041.3 Homo sapiens perforin 1 Hs.2200 Perforin 1 PRF1 perforin 1 (pore (pore forming protein) (pore forming protein), (PRF1), mRNA forming mRNA (cDNA clone Length = 2512 protein) IMAGE: 5752084), partial cds Length = 2502 473 DQ017060.1 Homo sapiens NM_002985.2 Homo sapiens chemokine Hs.514821 Chemokine CCL5 chemokine (C-C (C-C motif) ligand 5 (C-C motif) motif) ligand 5 (CCL5), mRNA ligand 5 (CCL5) gene, Length = 1237 complete cds Length = 12438 474 AY372494.1 Homo sapiens NM_004131.3 Homo sapiens granzyme B Hs.1051 Granzyme B GZMB endogenous (granzyme 2, cytotoxic T- (granzyme 2, granzyme B lymphocyte-associated cytotoxic T- precursor, mRNA, serine esterase 1) (GZMB), lymphocyte- complete cds mRNA Length = 955 associated Length = 951 serine esterase 1) 475 M17016.1 HUMSP13E Human NM_004131.3 Homo sapiens granzyme B Hs.1051 Granzyme B GZMB serine protease-like (granzyme 2, cytotoxic T- (granzyme 2, protein mRNA, lymphocyte-associated cytotoxic T- complete cds serine esterase 1) (GZMB), lymphocyte- Length = 934 mRNA Length = 955 associated serine esterase 1) 476 L78838.1 L78837S2 Homo NM_006725.2 Homo sapiens CD6 antigen Hs.502710 CD6 antigen CD6 sapiens T cell (CD6), mRNA Length = 3248 surface glycoprotein CD6 isoform (CD6) gene, exons 2-13, and complete cds, alternatively spliced Length = 17763 477 BC025691.1 Homo sapiens NM_000878.2 Homo sapiens interleukin 2 Hs.474787 Interleukin 2 IL2RB interleukin 2 receptor, beta (IL2RB), receptor, receptor, beta, mRNA Length = 4045 beta mRNA (cDNA clone MGC: 34584 IMAGE: 5207833), complete cds Length = 4035 478 BC033583.1 Homo sapiens CD2 NM_001767.2 Homo sapiens CD2 antigen Hs.523500 CD2 antigen CD2 antigen (p50), sheep (p50), sheep red blood cell (p50), sheep red blood cell receptor (CD2), mRNA red blood cell receptor, mRNA Length = 1579 receptor (cDNA clone MGC: 34621 IMAGE: 5227138), complete cds Length = 1579 479 BC014142.2 Homo sapiens NM_000181.1 Homo sapiens Hs.255230 Glucuronidase, GUSB glucuronidase, beta, glucuronidase, beta beta mRNA (cDNA clone (GUSB), mRNA MGC: 20659 Length = 2191 IMAGE: 4662011), complete cds Length = 2182 480 L10284.1 HUMIP90 Homo NM_001024649.1 Homo sapiens calnexin Hs.529890 Calnexin CANX sapiens integral (CANX), transcript variant membrane protein, 2, mRNA Length = 4900 calnexin, (IP90) mRNA, complete cds Length = 4117 481 BC073754.1 Homo sapiens NM_182810.1 Homo sapiens activating Hs.496487 Activating ATF4 activating transcription factor 4 (tax- transcription transcription factor 4 responsive enhancer factor 4 (tax- (tax-responsive element B67) (ATF4), responsive enhancer element transcript variant 2, mRNA enhancer B67), transcript Length = 1420 element variant 2, mRNA B67) (cDNA clone MGC: 88758 IMAGE: 6580199), complete cds Length = 1417 482 BC018857.2 Homo sapiens NM_001404.3 Homo sapiens eukaryotic Hs.557802 Transcribed eukaryotic translation translation elongation factor locus elongation factor 1 1 gamma (EEF1G), mRNA gamma, mRNA Length = 1429 (cDNA clone IMAGE: 3141750) Length = 1414 483 BC020057.1 Homo sapiens NM_002211.2 Homo sapiens integrin, Hs.429052 Integrin, beta ITGB1 integrin, beta 1 beta 1 (fibronectin receptor, 1 (fibronectin (fibronectin receptor, beta polypeptide, antigen receptor, beta polypeptide, CD29 includes MDF2, beta antigen CD29 MSK12) (ITGB1), transcript polypeptide, includes MDF2, variant 1A, mRNA antigen MSK12), transcript Length = 3700 CD29 variant 1A, mRNA includes (cDNA clone MDF2, MGC: 17220 MSK12) IMAGE: 3924411), complete cds Length = 3656 484 BC068201.1 Homo sapiens cDNA NM_012224.1 Homo sapiens NIMA (never Hs.481181 NIMA (never NEK1 clone in mitosis gene a)-related in mitosis IMAGE: 4771714, kinase 1 (NEK1), mRNA gene a)- partial cds Length = 5501 related Length = 1745 kinase 1 485 AF395009.1 AF395009 Homo sapiens glycoprotein lb (platelet), alpha polypeptide (GP1BA) gene, complete cds Length = 6241 486 BC039593.1 Homo sapiens NM_006676.4 Homo sapiens ubiquitin Hs.5452 Ubiquitin USP20 ubiquitin specific specific peptidase 20 specific peptidase 20, (USP20), transcript variant peptidase 20 transcript variant 2, 2, mRNA Length = 4490 mRNA (cDNA clone MGC: 48817 IMAGE: 5588842), complete cds Length = 4490 487 BC004491.2 Homo sapiens NM_153425.1 Homo sapiens TNFRSF1A- Hs.460996 TNFRSF1A- TRADD TNFRSF1A- associated via death associated associated via death domain (TRADD), via death domain, transcript transcript variant 2, mRNA domain variant 1, mRNA Length = 1959 (cDNA clone MGC: 11078 IMAGE: 3689007), complete cds Length = 1466 488 AC083899.6 Homo sapiens BAC Hs.135043 Transcribed clone RP11-223J6 locus from 2, complete sequence Length = 153666 489 Hs.126007 Hypothetical LOC375295 gene supported by BC013438 490 BC012160.1 Homo sapiens tumor NM_001242.3 Homo sapiens tumor Hs.355307 Tumor TNFRSF7 necrosis factor necrosis factor receptor necrosis receptor superfamily, superfamily, member 7 factor member 7, mRNA (TNFRSF7), mRNA receptor (cDNA clone Length = 1323 superfamily, MGC: 20393 member 7 IMAGE: 4575359), complete cds Length = 1323 491 BC035343.1 Homo sapiens NM_001838.2 Homo sapiens chemokine Hs.370036 Chemokine CCR7 chemokine (C-C (C-C motif) receptor 7 (C-C motif) motif) receptor 7, (CCR7), mRNA receptor 7 mRNA (cDNA clone Length = 2188 MGC: 34623 IMAGE: 5180758), complete cds Length = 2173 492 BC067540.1 Homo sapiens NM_002185.2 Homo sapiens interleukin 7 Hs.362807 Interleukin 7 IL7R interleukin 7 receptor (IL7R), mRNA receptor receptor, mRNA Length = 1809 (cDNA clone MGC: 79450 IMAGE: 6971846), complete cds Length = 1503 493 BC049847.1 Homo sapiens CD3E NM_000733.2 Homo sapiens CD3E Hs.3003 CD3E CD3E antigen, epsilon antigen, epsilon polypeptide antigen, polypeptide (TiT3 (TiT3 complex) (CD3E), epsilon complex), mRNA mRNA Length = 1377 polypeptide (cDNA clone (TiT3 MGC: 51948 complex) IMAGE: 5214563), complete cds Length = 1382 494 BC029273.1 Homo sapiens NM_021258.2 Homo sapiens interleukin Hs.110915 Interleukin IL22RA1 interleukin 22 22 receptor, alpha 1 22 receptor, receptor, alpha 1, (IL22RA1), mRNA alpha 1 mRNA (cDNA clone Length = 2811 MGC: 34232 IMAGE: 4347189), complete cds Length = 2824 495 AC013468.12 Homo sapiens BAC Hs.60772 O- OSGEPL1 clone RP11-455J20 sialoglycoprotein from 2, complete endopeptidase- sequence like 1 Length = 84115 496 AC084880.12 Homo sapiens 12 NM_014365.2 Homo sapiens heat shock Hs.400095 Heat shock HSPB8 BAC RP11-64B16 22 kDa protein 8 (HSPB8), 22 kDa (Roswell Park mRNA Length = 2056 protein 8 Cancer Institute Human BAC Library) complete sequence Length = 110001 497 BT007890.1 Synthetic construct NM_001803.2 Homo sapiens CD52 Hs.276770 CD52 CDW52 Homo sapiens antigen (CAMPATH-1 antigen CDW52 antigen antigen) (CD52), mRNA (CAMPATH- (CAMPATH-1 Length = 523 1 antigen) antigen) mRNA, partial cds Length = 186 498 BC069685.1 Homo sapiens cDNA NM_000073.1 Homo sapiens CD3G Hs.2259 CD3G antigen, CD3G clone antigen, gamma gamma IMAGE: 7262517, polypeptide (TiT3 complex) polypeptide (TiT3 containing frame- (CD3G), mRNA complex) shift errors Length = 822 Length = 737 499 BC018843.2 Homo sapiens NM_203431.1 Homo sapiens Hs.567674 Transcribed locus, peptidylprolyl peptidylprolyl isomerase A moderately similar isomerase A (cyclophilin A) (PPIA), to XP_526904.1 (cyclophilin A), transcript variant 3, mRNA PREDICTED: transcript variant 1, Length = 1707 similar to mRNA (cDNA clone peptidylprolyl IMAGE: 3139693) isomerase A Length = 811 isoform 1; cyclophilin A; peptidyl-prolyl cis- trans isomerase A; T cell cyclophilin; rotamase; cyclosporin A- binding protein [Pan troglodytes] 500 BC018840.2 Homo sapiens NM_000968.2 Homo sapiens ribosomal Hs.447798 Similar to ribosomal protein L4, protein L4 (RPL4), mRNA ribosomal mRNA (cDNA clone Length = 1449 protein L4; IMAGE: 3051153) 60S Length = 1439 ribosomal protein L4; homologue of Xenopus ribosomal protein L1 501 BC032107.2 Homo sapiens NM_012423.2 Homo sapiens ribosomal Hs.561045 Transcribed ribosomal protein protein L13a (RPL13A), locus, L13a, mRNA (cDNA mRNA Length = 1142 strongly clone similar to IMAGE: 4644246) XP_512821.1 Length = 1139 PREDICTED: similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein [Pan troglodytes] 502 BC018867.2 Homo sapiens NM_002295.4 Homo sapiens ribosomal Hs.563823 Transcribed ribosomal protein protein SA (RPSA), locus SA, transcript variant transcript variant 1, mRNA 1, mRNA (cDNA Length = 1155 clone IMAGE: 3141130) Length = 1035 503 BC028082.1 Homo sapiens NM_001558.2 Homo sapiens interleukin Hs.504035 Interleukin IL10RA interleukin 10 10 receptor, alpha 10 receptor, receptor, alpha, (IL10RA), mRNA alpha mRNA (cDNA clone Length = 3649 MGC: 40017 IMAGE: 5216986), complete cds Length = 3691 504 BC106007.1 Homo sapiens single NM_021805.1 Homo sapiens single Ig IL- Hs.501624 Single Ig IL- SIGIRR Ig IL-1R-related 1R-related molecule 1R-related molecule, mRNA (SIGIRR), mRNA molecule (cDNA clone Length = 1695 MGC: 110992 IMAGE: 6092503), complete cds Length = 1735 505 AY324320.1 Homo sapiens NM_032808.5 Homo sapiens leucine rich Hs.132344 Hypothetical LRRN6A leucine-rich repeat repeat neuronal 6A protein neuronal 6A (LRRN6A), mRNA LOC253044 (LRRN6A) mRNA, Length = 2932 complete cds Length = 2940 506 BC025703.1 Homo sapiens CD3Z NM_198053.1 Homo sapiens CD3Z Hs.156445 CD3Z CD3Z antigen, zeta antigen, zeta polypeptide antigen, zeta polypeptide (TiT3 (TiT3 complex) (CD3Z), polypeptide complex), transcript transcript variant 1, mRNA (TiT3 variant 1, mRNA Length = 1677 complex) (cDNA clone MGC: 34513 IMAGE: 5222574), complete cds Length = 1614 507 U07802.1 HSU07802 Human Hs.503093 Zinc finger ZFP36L2 Tis11d gene, protein 36, complete cds C3H type- Length = 5504 like 2 508 AF033347.1 AF033347 Homo NM_004519.2 Homo sapiens potassium Hs.374023 Potassium KCNQ3 sapiens potassium voltage-gated channel, voltage- channel homolog KQT-like subfamily, gated (KCNQ3) mRNA, member 3 (KCNQ3), channel, partial cds mRNA Length = 3097 KQT-like Length = 2755 subfamily, member 3 509 BC029848.1 Homo sapiens tumor NM_003820.2 Homo sapiens tumor Hs.512898 Tumor TNFRSF14 necrosis factor necrosis factor receptor necrosis receptor superfamily, superfamily, member 14 factor member 14 (herpesvirus entry receptor (herpesvirus entry mediator) (TNFRSF14), superfamily, mediator), mRNA mRNA Length = 1730 member 14 (cDNA clone (herpesvirus MGC: 35320 entry IMAGE: 5178561), mediator) complete cds Length = 1756 510 AF129756.1 DJ201G24 Homo NM_009588.1 Homo sapiens lymphotoxin Hs.376208 Lymphotoxin LTB sapiens MSH55 beta (TNF superfamily, beta (TNF gene, partial cds; member 3) (LTB), transcript superfamily, and CLIC1, DDAH, variant 2, mRNA member 3) G6b, G6c, G5b, G6d, Length = 848 G6e, G6f, BAT5, G5b, CSK2B, BAT4, G4, Apo M, BAT3, BAT2, AIF-1, 1C7, LST-1, LTB, TNF, and LTA genes, complete cds Length = 184666 511 BC035576.1 Homo sapiens NM_003954.1 Homo sapiens mitogen- Hs.404183 Mitogen- MAP3K14 mitogen-activated activated protein kinase activated protein kinase kinase kinase kinase 14 protein kinase 14, mRNA (MAP3K14), mRNA kinase (cDNA clone Length = 4596 kinase MGC: 45335 kinase 14 IMAGE: 5497185), complete cds Length = 4452 512 AF340053.1 Homo sapiens NM_000873.2 Homo sapiens intercellular Hs.431460 Intercellular ICAM2 isolate H#8 adhesion molecule 2 adhesion intercellular adhesion (ICAM2), mRNA molecule 2 molecule 2 (ICAM2) Length = 1035 mRNA, complete cds Length = 1020 513 AC011382.4 Homo sapiens NM_005211.2 Homo sapiens colony Hs.483829 Colony CSF1R chromosome 5 clone stimulating factor 1 stimulating CTB-13H5, complete receptor, formerly factor 1 sequence McDonough feline sarcoma receptor, Length = 86829 viral (v-fms) oncogene formerly homolog (CSF1R), mRNA McDonough Length = 3985 feline sarcoma viral (v-fms) oncogene homolog 514 BC025782.1 Homo sapiens CD4 NM_000616.2 Homo sapiens CD4 antigen Hs.17483 CD4 antigen CD4 antigen (p55), mRNA (p55) (CD4), mRNA (p55) (cDNA clone Length = 3084 MGC: 34241 IMAGE: 5226427), complete cds Length = 3084 515 BC098564.1 Homo sapiens serpin NM_004568.4 Homo sapiens serpin Hs.519523 Serpin SERPINB6 peptidase inhibitor, peptidase inhibitor, clade B peptidase clade B (ovalbumin), (ovalbumin), member 6 inhibitor, member 6, mRNA (SERPINB6), mRNA clade B (cDNA clone Length = 1665 (ovalbumin), MGC: 111370 member 6 IMAGE: 30563105), complete cds Length = 1421 516 AC129492.6 Homo sapiens NM_014232.1 Homo sapiens vesicle- Hs.25348 Vesicle- VAMP2 chromosome 17, associated membrane associated clone RP11-599B13, protein 2 (synaptobrevin 2) membrane complete sequence (VAMP2), mRNA protein 2 Length = 196037 Length = 2159 (synaptobrevin 2) 517 BC084538.1 Homo sapiens v-akt NM_001014432.1 Homo sapiens v-akt murine Hs.525622 V-akt murine AKT1 murine thymoma thymoma viral oncogene thymoma viral oncogene homolog 1 (AKT1), viral homolog 1, transcript transcript variant 2, mRNA oncogene variant 2, mRNA Length = 2878 homolog 1 (cDNA clone MGC: 99656 IMAGE: 6645486), complete cds Length = 2868 518 BC022512.1 Homo sapiens NM_000442.2 Homo sapiens Hs.514412 Platelet/endothelial PECAM1 platelet/endothelial platelet/endothelial cell cell cell adhesion adhesion molecule (CD31 adhesion molecule (CD31 antigen) (PECAM1), mRNA molecule antigen), mRNA Length = 3189 (CD31 (cDNA clone antigen) MGC: 26550 IMAGE: 4816878), complete cds Length = 3189 519 BC016838.2 Homo sapiens NM_031311.2 Homo sapiens Hs.233389 Carboxypeptidase, CPVL carboxypeptidase, carboxypeptidase, vitellogenic- vitellogenic-like, vitellogenic-like (CPVL), like transcript variant 2, transcript variant 1, mRNA mRNA (cDNA clone Length = 1638 MGC: 10029 IMAGE: 3888647), complete cds Length = 1772 520 M20431.1 HUMMHDQAR NM_002122.3 Homo sapiens major Hs.555872 Major HLA-DQA1 Human MHC class II histocompatibility complex, histocompatibility HLA-DQ-alpha class II, DQ alpha 1 (HLA- complex, (DR2-DQw1/DR4 DQA1), mRNA class II, DQ DQw3) mRNA, Length = 1542 alpha 1 partial cds, clone ROF1.1-alpha Length = 1030 521 M29615.1 HUMMHDXAR2 NM_020056.2 Homo sapiens major Hs.387679 Major HLA-DQA1 Human MHC class II histocompatibility complex, histocompatibility HLA-DX-alpha chain class II, DQ alpha 2 (HLA- complex, gene, exons 2 DQA2), mRNA class II, DQ through 4 Length = 1709 alpha 1 Length = 2522 522 M89957.1 Homo sapiens cell NM_021602.1 Homo sapiens CD79B Hs.89575 CD79B CD79B surface glycoprotein antigen (immunoglobulin- antigen (IGB) mRNA, associated beta) (CD79B), (immunoglobulin- complete cds transcript variant 2, mRNA associated Length = 1270 Length = 958 beta) 523 BC028078.1 Homo sapiens NM_001337.3 Homo sapiens chemokine Hs.78913 Chemokine CX3CR1 chemokine (C—X3—C (C—X3—C motif) receptor 1 (C—X3—C motif) receptor 1, (CX3CR1), mRNA motif) mRNA (cDNA clone Length = 3108 receptor 1 MGC: 40024 IMAGE: 5216452), complete cds Length = 3119 524 BC073986.1 Homo sapiens NM_006682.1 Homo sapiens fibrinogen- Hs.557207 Transcribed fibrinogen-like 2, like 2 (FGL2), mRNA locus, weakly mRNA (cDNA clone Length = 1496 similar to MGC: 87984 NP_006673.1 IMAGE: 5748616), fibrinogen- complete cds like 2; Length = 1533 fibrinogen- like protein 2; fibroleukin [Homo sapiens] 525 BC037236.1 Homo sapiens dual NM_001946.2 Homo sapiens dual Hs.298654 Dual DUSP6 specificity specificity phosphatase 6 specificity phosphatase 6, (DUSP6), transcript variant phosphatase 6 transcript variant 1, 1, mRNA Length = 2842 mRNA (cDNA clone MGC: 35368 IMAGE: 5183133), complete cds Length = 2874 526 AF522250.1 Homo sapiens MHC NM_019111.3 Homo sapiens major Hs.555872 Major HLA-DQA1 class II antigen histocompatibility complex, histocompatibility (HLA-DQA1/DRA) class II, DR alpha (HLA- complex, mRNA, complete cds DRA), mRNA Length = 1267 class II, DQ Length = 811 alpha 1 527 M23905.1 HUMMHDRC03 NM_033554.2 Homo sapiens major Hs.347270 Major HLA-DPA1 Human MHC class II histocompatibility complex, histocompatibility lymphocyte antigen class II, DP alpha 1 (HLA- complex, (DPw4-alpha-1) gene DPA1), mRNA class II, DP Length = 627 Length = 1157 alpha 1 528 AY663400.1 Homo sapiens NM_002124.1 Homo sapiens major Hs.520049 Major HLA-DRB1 voucher Coriell Cell histocompatibility complex, histocompatibility Repository DNA class II, DR beta 1 (HLA- complex, sample NA01018 DRB1), mRNA class II, DR MHC class II antigen Length = 1182 beta 4 (HLA-DQB1) gene, HLA-DQB1- DQB1*050101 allele, MHC class II antigen (HLA-DQA1) gene, HLA-DQA1- DQA1*010102 allele, and MHC class II antigen (HLA-DRB1) gene, complete cds Le 529 BC007920.2 Homo sapiens major NM_022555.3 Homo sapiens major Hs.545653 Major HLA-DRB6 histocompatibility histocompatibility complex, histocompatibility complex, class II, DR class II, DR beta 3 (HLA- complex, beta 1, mRNA DRB3), mRNA class II, DR (cDNA clone Length = 1158 beta 6 MGC: 14111 (pseudogene) IMAGE: 4309837), complete cds Length = 1218 530 BC018726.1 Homo sapiens CD74 NM_001025158.1 Homo sapiens CD74 Hs.533282 Non-POU NONO antigen (invariant antigen (invariant domain polypeptide of major polypeptide of major containing, histocompatibility histocompatibility complex, octamer- complex, class II class II antigen-associated) binding antigen-associated), (CD74), transcript variant 3, transcript variant 2, mRNA Length = 1155 mRNA (cDNA clone MGC: 31825 IMAGE: 4853578), complete cds Length = 1327 531 M16942.1 HUMMHDRBU NM_021983.4 Homo sapiens major Hs.545653 Major HLA-DRB6 Human MHC class II histocompatibility complex, histocompatibility HLA-DRw53- class II, DR beta 4 (HLA- complex, associated DRB4), mRNA class II, DR glycoprotein beta- Length = 1193 beta 6 chain mRNA, (pseudogene) complete cds Length = 1141 532 BC009234.2 Homo sapiens major NM_002125.3 Homo sapiens major Hs.534322 Major HLA-DRB5 histocompatibility histocompatibility complex, histocompatibility complex, class II, DR class II, DR beta 5 (HLA- complex, beta 5, mRNA DRB5), mRNA class II, DR (cDNA clone Length = 1171 beta 3 MGC: 16550 IMAGE: 4054398), complete cds Length = 1185

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1-34. (canceled)
 35. A method for detection of possible postoperative tissue incompatibility reactions following a liver transplantation, comprising: obtaining a gene expression profile from in vitro samples obtained from patients, including genes with characteristic expression associated with patient condition following liver transplantation, and monitoring the expression of characteristic genes as indicators of possible postoperative occurring tissue incompatibility reactions.
 36. The method of claim 35, wherein the patient has received a liver transplant and is monitored for risk of a rejection due to tissue incompatibility.
 37. The method of claim 35, wherein the expression profile includes at least 4 polynucleotides selected from SEQ-IDs 1 through
 532. 38. The method of claim 35, wherein gene activities of polynucleotides with SEQ-IDs No 1 through 532 are compared and these expression behaviors are compiled into gene activity clusters.
 39. The method of claim 38, wherein the individual clusters are composed as follows: Cluster 1: Gene activities of SEQ-IDs No. 1 through 132; Cluster 2: Gene activity data of SEQ-IDs No. 133 through 353; Cluster 3: Gene activity data of SEQ-IDs No. 354 through 410; and Cluster 4: Gene activity data of SEQ-IDs No 411 through
 532. 40. The method of claim 35, wherein the method is used as criteria for inclusion or exclusion of liver transplant patients in clinical studies of phases 2-4.
 41. The method of claim 35, wherein the method is used for establishing gene activity data for electronic further processing.
 42. The method of claim 35, wherein gene activity data is obtained and employed for production of software for the description of the individual prognosis of the patient, for diagnostic purposes and/or patient data management systems.
 43. The method of claim 35, wherein the in vitro expression profiles obtained from a patient sample are employed for production of clinical expert systems and/or for modeling of cellular signal transmission pathways.
 44. The method of claim 35, wherein for establishment of the gene expression profile a specific gene and/or gene fragment is employed, which is selected from the group comprised of SEQ-ID No. 1 through SEQ-ID No. 532 as well as gene fragments thereof with at least 5-2000 nucleotides.
 45. The method of claim 44, wherein the gene fragment includes 20-200, preferably 20-80 nucleotides.
 46. The method of claim 35, wherein the gene expression profile is determined using hybridization processes.
 47. The method of claim 46, wherein the hybridization process is based on microarrays.
 48. A process for in-vitro measurement of (a) gene expression profiles and/or (b) at least one gene activity cluster, for detection of possible postoperative tissue incompatibility reactions following a liver transplantation, comprising identifying the gene activity of a plurality of particular genes in a patient sample which are associated with a liver transplantation, monitoring the gene activity in a patient to be diagnosed for possible postoperative tissue incompatibility reactions following a liver transplantation, wherein the genes and/or gene fragments selected for the monitoring of the postoperative condition are selected from the group comprised of: SEQ-ID No. 1 through SEQ-ID No. 532 as well as gene fragments thereof with at least 5-2000 nucleotides.
 49. The process according to claim 48, wherein the gene fragments include 20-200, preferably 20-80 nucleotides.
 50. The process according to claim 48, wherein at least 4 to 100 different genes and/or gene fragments are employed.
 51. The process according to claim 48, wherein at least 200 different genes and/or gene fragments are employed.
 52. The process according to claim 48, wherein at least 200 to 500 different genes and/or gene fragments are employed.
 53. The process according to claim 48, wherein at least 500 to 1000 different genes and/or gene fragments are employed.
 54. The process according to claim 48, wherein at least 1000 to 2000 different genes and/or gene fragments are employed.
 55. The process according to claim 48, wherein the genes or gene fragments of SEQ-ID No. 1 through SEQ-ID No. 532 and/or the sequences derived from their RNA are replaced by one or more of: synthetic analogs, aptamers, spiegelmeres as well as peptido- and morpholinonucleic acids.
 56. The process according to claim 48, wherein the synthetic analogs of the genes include 5-100, preferably approximately 70 base pairs.
 57. The process according to claim 48, wherein the gene activities are determined using a hybridization processes.
 58. The process according to claim 57, wherein the gene activity is determined using microarrays.
 59. The process according to claim 48, wherein the gene activity is determined by processes independent of hybridization, in particular enzymatic and/or chemical hydrolysis and/or amplification processes, preferably PCR, subsequent quantification of the nucleic acids and/or of derivatives and/or fragments thereof.
 60. The process according to claim 48, wherein the sample is selected from: body fluids, in particular blood, serum, urine, ascites fluid, seminal fluid, saliva, aspirate; cellular contents or a mixture thereof.
 61. The process according to claim 48, wherein sample, in particular cell sample, is subjected to a lytic treatment in order to liberate cellular contents.
 62. A method for screening of active substances for usefulness against rejection reactions in patients with liver transplants and/or for evaluation of the therapy effect of active substances against rejection reactions of patients with liver transplants, the method comprising compiling a gene expression profile from in vitro samples obtained from patients, including genes with characteristic expression associated with patient condition following liver transplantation, and/or of the therefore employed probe, which genes are selected from the group comprised of SEQ-ID No. 1 through SEQ-ID No. 532 as well as gene fragments thereof with at least 5-2000 nucleotides, the method comprising (a) administering an active substance, and (b) monitoring the gene profile for evidence of: switching off a target gene, changing the activity of a target gene and/or determining the activity of a gene or the therefrom derived protein products.
 63. The process according to claim 62, wherein hybridization capable synthetic analogs of the probes are employed.
 64. The process according to claim 62, wherein the gene fragments include 20-200, preferably 20-80 nucleotides.
 65. A kit, comprising: a selection of at least 4 polynucleotides with sequences according to SEQ-ID No. 1 through SEQ-ID No. 532 and/or gene fragments thereof with at least 5-2000 nucleotides, and printed instructions for determination of gene expression profiles in vitro in a patient sample, for a determination of possible tissue incompatibility reactions following a liver transplantation.
 66. A cluster of genes useful for detection of possible postoperative tissue incompatibility reactions following a liver transplantation, the cluster comprising at least one polynucleotide selected from the group comprised of SEQ-ID No. 1 through
 132. 67. A cluster of genes useful for detection of possible postoperative tissue incompatibility reactions following a liver transplantation, the cluster comprising at least one polynucleotide selected from the group comprised of SEQ-ID No. 133 through
 353. 68. A cluster of genes useful for detection of possible postoperative tissue incompatibility reactions following a liver transplantation, the cluster comprising at least one polynucleotide selected from the group comprised of SEQ-ID No. 354 through
 410. 69. A cluster of genes useful for detection of possible postoperative tissue incompatibility reactions following a liver transplantation, the cluster comprising at least one polynucleotide selected from the group comprised of SEQ-ID No. 411 through
 532. 